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Molecular profiles of gastroenteropancreatic endocrine tumors

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Abstract

Neuroendocrine tumors of the gastroenteropancreatic system are defined by their endocrine phenotype and share many histopathological and clinical features. However, the fact that the hormone production of tumors depends on their site of origin, that the tumors differ in their biology, and that the association with familial syndromes is nonrandom suggests heterogeneity. It is therefore conceivable that the gastroenteropancreatic neuroendocrine tumors also differ in their molecular profile. This review summarizes and discusses the available data in this field.

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Acknowledgments

This work was supported in part by the National Science Research Foundation (31-618845.00; AP and PK). The authors would like to thank Professor Günter Klöppel and Mrs. Kay Dege for critical reading and editing the manuscript and Parvin Saremaslani, Tamara Locher, Claudia Bonvin, and Sonja Schmid for their excellent technical support.

Conflict of interest statement

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Pathology, University Hospital Zürich, Zurich, Switzerland

    Aurel Perren

  2. Department of Pathology, Klinikum rechts der Isar, Technische Universität München, 81675, Munich, Germany

    Aurel Perren

  3. Department of Pathology, University of Kiel, Kiel, Germany

    Martin Anlauf

  4. Institute of Pathology, Stadtspital Triemli, Zürich, Switzerland

    Paul Komminoth

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  1. Aurel Perren
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Correspondence to Aurel Perren.

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Perren, A., Anlauf, M. & Komminoth, P. Molecular profiles of gastroenteropancreatic endocrine tumors. Virchows Arch 451 (Suppl 1), 39–46 (2007). https://doi.org/10.1007/s00428-007-0449-9

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