Abstract
Main conclusion
Photosynthetic production of isoprenoids in cyanobacteria is considered in terms of metabolic engineering and biological importance.
Metabolic engineering of photosynthetic bacteria (cyanobacteria) has been performed to construct bio-solar cell factories that convert carbon dioxide to various value-added chemicals. Isoprenoids, which are found in nature and range from essential cell components to defensive molecules, have great value in cosmetics, pharmaceutics, and biofuels. In this review, we summarize the recent engineering of cyanobacteria for photosynthetic isoprenoids production as well as carbon molar basis comparisons with heterotrophic isoprenoids production in engineered Escherichia coli.
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Abbreviations
- IPP:
-
Isopentenyl diphosphate
- DMAPP:
-
Dimethylallyl pyrophosphate
- MEP:
-
Methylerythritol 4-phosphate
- MVA:
-
Mevalonate
- GPP:
-
Geranyl diphosphate
- FPP:
-
Farnesyl diphosphate
- GGPP:
-
Geranylgeranyl diphosphate
- DCW:
-
Dry cell weight
- PCC 6803:
-
Synechocystis sp. PCC 6803
- PCC 7942:
-
Synechococcus elongatus PCC 7942
- PCC 7120:
-
Anabaena sp. PCC 7120
- PCC 7002:
-
Synechococcus sp. PCC 7002
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Acknowledgements
The authors thank Prof. Sang Jun Sim at Korea University and Prof. EonSon Jin at Hanyang University for valuable discussion.
Funding
This work was supported by Korea CCS R&D Center (KCRC) (2017M1A8A1072034) and Basic Science Research Program (2017R1A2B2002566) through the National Research Foundation of Korea, funded by the Korean Government (Ministry of Science and ICT). In addition, this work was partially supported by the Golden Seed Project (213008-05-1-WT911) grant, funded by the Ministry of Agriculture and the Ministry of Oceans and Fisheries.
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Ko, S.C., Lee, H.J., Choi, S.Y. et al. Bio-solar cell factories for photosynthetic isoprenoids production. Planta 249, 181–193 (2019). https://doi.org/10.1007/s00425-018-2969-8
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DOI: https://doi.org/10.1007/s00425-018-2969-8