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Clinicopathological features and surgical outcomes of intraductal tubulopapillary neoplasm of the pancreas: a systematic review

  • Systematic Reviews and Meta-Analyses
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Abstract

Background and aims

Intraductal tubulopapillary neoplasms (ITPNs) of the pancreas are rare. The purpose of this study was to collate and analyze published data on ITPNs of the pancreas to determine the clinicopathological features of the tumors and the surgical outcomes of patients.

Patients and methods

We searched MEDLINE and Igakuchuo-Zasshi for the period of 1980 to 2015 for case reports on surgical resection for ITPN of the pancreas. We evaluated the clinicopathological data associated with pancreatic ITPNs, the prognosis for each patient, and surgical outcomes described in the case reports.

Results

We obtained clinicopathological data for 58 patients (33 men and 25 women) with a mean age of 61 years (range, 35–84 years) who had undergone surgical resection for ITPN of the pancreas, including one patient from our clinic. Although ITPNs of the pancreas have different clinicopathological features to intraductal papillary mucinous neoplasms, the treatment strategy for patients with ITPNs is the same as for patients with other cystic neoplasms of the pancreas. The immunohistochemical features of ITPNs included testing positive for cytokeratin 7 and/or cytokeratin 19 and negative for trypsin, MUC2, MUC5AC, and fascin. The overall 1-, 3-, and 5-year survival rates after surgery for the 37 cases with available data were 97.3, 80.7, and 80.7 %, respectively.

Conclusion

Surgical treatment is the only curative management option for patients with ITPN of the pancreas. To determine the best management strategy for this tumor and improve accuracy of prognosis for patients, we will continue to collect and analyze epidemiological and pathological data.

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Authors and Affiliations

  1. Department of Gastroenterological Surgery, Kochi Health Sciences Center, 2125-1 Ike, Kochi City, Kochi, 781-8555, Japan

    Keiichi Date, Takehiro Okabayashi, Yasuo Shima, Tatsuaki Sumiyoshi & Akihito Kozuki

  2. Department of Diagnostic Pathology, Kochi Health Sciences Center, Kochi, Japan

    Jun Iwata & Manabu Matsumoto

  3. Department of Radiology, Kochi Health Sciences Center, Kochi, Japan

    Sojiro Morita, Yasuhiro Hata, Yoshihiro Noda & Akihito Nishioka

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  1. Keiichi Date
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  2. Takehiro Okabayashi
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Corresponding author

Correspondence to Takehiro Okabayashi.

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Funding

This work was supported by the Kochi Organization for Medical Reformation and Renewal Grants.

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethics committee of the Kochi Health Sciences Center and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. A patient provided written informed consent.

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Date, K., Okabayashi, T., Shima, Y. et al. Clinicopathological features and surgical outcomes of intraductal tubulopapillary neoplasm of the pancreas: a systematic review. Langenbecks Arch Surg 401, 439–447 (2016). https://doi.org/10.1007/s00423-016-1391-6

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  • DOI: https://doi.org/10.1007/s00423-016-1391-6

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