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Systematic review of resectable intraductal tubulopapillary neoplasm with special reference to recurrence patterns

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Abstract

Purpose

Intraductal tubulopapillary neoplasm is a rare pancreatic tumor. The purpose of this study was to clarify the recurrence type and prognosis in recurrent cases after intraductal tubulopapillary neoplasm resection.

Methods

PubMed was searched for previous reports on surgical resection of intraductal tubulopapillary neoplasm of the pancreas that were published from 2009 to July 2020. The clinical features obtained from these reports were summarized and analyzed.

Results

The clinicopathological data of 35 intraductal tubulopapillary neoplasm cases were obtained. Of these, 21 were males, and 14 were females, with an average age of 57.9 years old. Invasive findings were observed in 21 of 35 patients (60%). Recurrence was observed in 11 of the 35 cases (31.4%), including remnant pancreatic recurrence in 6 cases (17.1%) and liver metastasis in 5 cases (14.3%). The tumor size was significantly larger in the liver metastasis group than in the remnant pancreas recurrence group (P = 0.04), and patients with liver metastases tended to have a poorer prognosis than those with remnant pancreas recurrence.

Conclusions

The recurrence type of intraductal tubulopapillary neoplasm resection was mainly remnant pancreatic recurrence and liver metastasis recurrence. Total pancreatectomy for remnant pancreatic recurrence may be suitable because of its good prognosis.

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References

  1. Yamaguchi H, Shimizu M, Ban S, Koyama I, Hatori T, Fujita I, et al. Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol. 2009;33:1164–72.

    Article  Google Scholar 

  2. Adsay NV, Fukushima N, Furukawa T, Hruban RH, Klimstra DS, Klöppel G, et al. Intraductal neoplasm of the pancreas. In: Boston FT, Carneiro F, Hruban RH, Heise ND, et al., editors. World Health Organization classification of 14 tumours of the digestive system. Lyon: IARC Press; 2010; p. 304–13.

    Google Scholar 

  3. Basturk O, Adsay V, Askan G, Dhall D, Zamboni G, Shimizu M, et al. Intraductal tubulopapillary neoplasm of the pancreas: a clinicopathologic and immunohistochemical analysis of 33 cases. Am J Surg Pathol. 2017;41(3):313–25.

    Article  Google Scholar 

  4. Date K, Okabayashi T, Shima Y, Iwata J, Sumiyoshi T, Kozuki A, et al. Clinicopathological features and surgical outcomes of intraductal tubulopapillary neoplasm of the pancreas: a systematic review. Langenbeck’s Arch Surg. 2016;401:439–47.

    Article  Google Scholar 

  5. Kuan LL, Dennison AR, Garcea G. Intraductal tubulopapillary neoplasm of the pancreas and bile duct: a review. Pancreas. 2020;49(4):498–502.

    Article  Google Scholar 

  6. Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535. https://doi.org/10.1136/bmj.b2535.

  7. Bhuva N, Wasan H, Spalding D, Stamp G, Harrison M. Intraductal tubulopapillary neoplasm of the pancreas as a radiation induced malignancy. BMJ Case Rep. 2011. https://doi.org/10.1136/bcr.09.2011.4777.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Tajiri T, Tate G, Matsumoto K, Hoshino H, Iwamura T, Kodaira Y, et al. Diagnostic challenge: intraductal neoplasms of the pancreatobiliary system. Pathol Res Pract. 2012;208(11):691–6.

    Article  Google Scholar 

  9. Jokoji R, Tsuji H, Tsujimoto M, Shinno N, Tori M. Intraductal tubulopapillary neoplasm of pancreas with stromal osseous and cartilaginous metaplasia; a case report. Pathol Int. 2012;62:339–43.

    Article  Google Scholar 

  10. Urata T, Naito Y, Nagamine M, Izumi Y, Tonaki G, Iwasaki H, et al. Intraductal tubulopapillary neoplasm of the pancreas with somatic BRAF mutation. Clin J Gastroenterol. 2012;5:413–20.

    Article  Google Scholar 

  11. Guan H, Gurda G, Lennon AM, Hruban RH, Erozan YS. Intraductal tubulopapillary neoplasm of the pancreas on fine needle aspiration: case report with differential diagnosis. Diagn Cytopathol. 2014;42(2):156–60.

    Article  Google Scholar 

  12. Kasugai H, Tajiri T, Takehara Y, Mukai S, Tanaka J, Kudo SE. Intraductal tubulopapillary neoplasms of the pancreas: case report and review of the literature. J Nippon Med Sch. 2013;80:224–9.

    Article  Google Scholar 

  13. Someya Y, Nakamoto Y, Nakatani K, Kawaguchi M, Minamiguchi S, Togashi K. 18F-FDG uptake in intraductal tubulopapillary neoplasm of the pancreas. Clin Nucl Med. 2014;39(4):e277–80.

    Article  Google Scholar 

  14. Del Chiaro M, Mucelli RP, Blomberg J, Segersvärd R, Verbeke C. Is intraductal tubulopapillary neoplasia a new entity in the spectrum of familial pancreatic cancer syndrome? Fam Cancer. 2014;13(2):227–9.

    PubMed  Google Scholar 

  15. Ahls MG, Niedergethmann M, Dinter D, Sauer C, Lüttges J, Post S, et al. Case report: intraductal tubulopapillary neoplasm of the pancreas with unique clear cell phenotype. Diagn Pathol. 2014;9:11.

    Article  Google Scholar 

  16. Furuhata A, Minamiguchi S, Mikami Y, Kodama Y, Sumiyoshi S, Adachi S, et al. Intraductal tubulopapillary neoplasm with expansile invasive carcinoma of the pancreas diagnosed by endoscopic ultrasonography-guided fine needle aspiration: a case report. Diagn Cytopathol. 2014;42(4):314–20.

    Article  Google Scholar 

  17. Tajima S. Intraductal tubulopapillary neoplasm of the pancreas suspected by endoscopic ultrasonography-fine-needle aspiration cytology: report of a case confirmed by surgical specimen histology. Diagn Cytopathol. 2015;43(12):1003–6.

    Article  Google Scholar 

  18. Takayama S, Maeda T, Nishihara M, Kanazawa A, Chong HS, Oka H, et al. A case of intraductal tubulopapillary neoplasm of pancreas with severe calcification, a potential pitfall in diagnostic imaging. Pathol Int. 2015;65(9):501–6.

    Article  Google Scholar 

  19. Yoshida Y, Matsubayashi H, Sasaki K, Kanemoto H, Uesaka K, Ono H, et al. Intraductal tubulopapillary neoplasm of the pancreatic branch duct showing atypical images. J Dig Dis. 2015;16:357–61.

    Article  Google Scholar 

  20. Kitaguchi K, Kato Y, Kojima M, Okuobo S, Takahashi D, Okada R, et al. A resected case of intraductal tubulopapillary neoplasm of the pancreas: report of a case. Int Surg. 2015;100(2):281–6.

    Article  Google Scholar 

  21. Matthews Y, McKenzie C, Byrne C, Kench JG. Intraductal tubulopapillary neoplasm of pancreas with associated invasive carcinoma, lymph node, rectal and hepatic metastases. Pathology. 2015;47(2):169–71.

    Article  Google Scholar 

  22. Kölby D, Thilén J, Andersson R, Sasor A, Ansari D. Multifocal intraductal tubulopapillary neoplasm of the pancreas with total pancreatectomy:report of a case and review of literature. Int J Clin Exp Pathol. 2015;8(8):9672–80.

    PubMed  PubMed Central  Google Scholar 

  23. Savant D, Lee L, Das K. Intraductal tubulopapillary neoplasm of the pancreas masquerading as pancreatic neuroendocrine carcinoma: review of the literature with a case report. Acta Cytol. 2016;60(3):267–74.

    Article  CAS  Google Scholar 

  24. Fujimoto Y, Tomimaru Y, Tamura H, Noguchi K, Nagase H, Hamabe A, et al. Pancreatic intraductal tubulopapillary neoplasm with associated invasive cancer successfully treated by total pancreatectomy: a case report. Oncol Lett. 2017;14(1):153–8.

    Article  Google Scholar 

  25. Kuscher S, Steinle H, Soleiman A, Öfner D, Schneeberger S, Oberhuber G. Intraductal tubulopapillary neoplasm (ITPN) of the pancreas associated with an invasive component: a case report with review of the literature. World J Surg Oncol. 2017;15(1):203.

    Article  Google Scholar 

  26. Kovacevic B, Añó PL, Toxværd A, Vilmann P, Kalaitzakis E. Intraductal tubulopapillary neoplasm of the pancreas diagnosed by endoscopic ultrasonography-guided fine needle aspiration. Endoscopy. 2017;49(11):E266–7.

    Article  Google Scholar 

  27. Maghrebi H, Makni A, Rhaeim R, Zehani A, Bensafta Z. Intraductal tubulopapillary neoplasm: a new entity in the spectrum of pancreatic intraductal neoplasms. J Clin Diagn Res. 2017;11(9):PD14–6. https://doi.org/10.7860/JCDR/2017/28596.10663.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Niu L, Xu Z, Liu H, Cao H, Yang G. Intraductal tubulopapillary neoplasm accompanied by invasive carcinoma of the pancreas: a case report and review of the literature. Mol Clin Oncol. 2017;6(5):676–82.

    Article  CAS  Google Scholar 

  29. Inomata K, Kitago M, Obara H, Fuji-Nishimura Y, Shinoda M, Yagi H, et al. Conncurrent presentation of an intraductal tubulopapillary neoplasm and intraductal papillary mucinous neoplasm in the branch duct of the pancreas, with a superior mesenteric artery aneurysm: a case report. World J Surg Oncol. 2018;16:83.

    Article  Google Scholar 

  30. Sakamoto S, Tsuruga Y, Fujii Y, Shomura H, Hattori A, Kazui K, et al. Intraductal tubulopapillary neoplasm of the pancreas presenting as recurrent acute pancreatitis: a case report. Int J Surg Case Rep. 2018;48:122–5.

    Article  Google Scholar 

  31. Saeki K, Miyasaka Y, Ohishi Y, Yamamoto T, Matsuda R, Mochidome N, et al. Intrapancreatic recurrence of intraductal tubulopapillary neoplasm (ITPN) 16 years after the initial surgery for noninvasive ITPN: a case report. Surg Case Rep. 2018;4:96.

    Article  Google Scholar 

  32. Umemura A, Ishida K, Nitta H, Takahara T, Hasegawa Y, Makabe K, et al. A rare case of intraductal tubulopapillary neoplasm of the pancreas rupturing and causing acute peritonitis. Case Rep Gastroenterol. 2017;11(3):661–6.

    Article  Google Scholar 

  33. Umemura A, Ishida K, Nitta H, Takahara T, Hasegawa Y, Makabe K, et al. An extremely rare case who underwent total remnant pancreatectomy due to recurrent pancreatic metastasis of intraductal tubulopapillary neoplasm. Clin J Gastroenterol. 2019;12(2):153–9.

    Article  Google Scholar 

  34. Ko K, Nishida Y, Sasahara K, Kishimoto H, Noriaki O, Tauchi K, et al. A resected case of recurrent ITPN in the remnant pancreas after pancreatoduodenectomy. Surg Case Rep. 2019;5(1):33.

    Article  Google Scholar 

  35. Fritz S, Küper-Steffen R, Feilhauer K, Sommer CM, Richter GM, Bosse A, et al. Intraductal tubular papillary neoplasm (ITPN), a novel entity of pancreatic epithelial neoplasms and precursor of cancer: a case report and review of the literature. Int J Surg Case Rep. 2019;55:187–91.

    Article  Google Scholar 

  36. Zhang J, Ren S, Wang J, Ye D, Zhang H, Qiu W, et al. Imaging findings of intraductal tubulopapillary neoplasm (ITPN) of the pancreas: two case reports and literature review. Medicine (Baltimore). 2019;98(6):e14426. https://doi.org/10.1097/MD.0000000000014426.

  37. Zhou PC, Chen XP, Li B, Xie YC, Zhou TJ, Wang JM, et al. Intraductal tubulopapillary neoplasm (ITPN) of the pancreas with invasive cancer misdiagnosed as a mesenteric cyst for 12 years: a case report and literature review. Int J Clin Exp Pathol. 2019;12(3):1041–6.

    PubMed  PubMed Central  Google Scholar 

  38. Dalal A, Patil G, Vadgaonkar A, Maydeo A. A rare case of intraductal tubulopapillary neoplasm of the pancreas—case report (with video). Postgrad Med. 2020;132(3):270–3. https://doi.org/10.1080/00325481.2019.1669058.

  39. Nabrinsky E, Baste CL, Gonzalez M, James E. Intraductal tubulopapillary neoplasm of the pancreas presenting as a localized pancreatic tumor in a 52-year-old woman: focusing on a rare pancreatic malignancy and contrasting to intrapapillary mucinous neoplasm. Cureus. 2020;12(6):e8548. https://doi.org/10.7759/cureus.8548.

  40. Ohno A, Kaku T, Kawabe K. Fine-needle-aspiration using forward-viewing echoendoscope for the recurrence of intraductal tubulopapillary neoplasm. Dig Endosc. 2020;32(5):e102–3.

    Article  Google Scholar 

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Acknowledgements

We thank H. Nikki March, PhD, from Edanz Group (https://en-author-services.edanzgroup.com/ac) for editing a draft of this manuscript.

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Authors and Affiliations

  1. Division of Hepatobiliary and Pancreatic Surgery, Department of General Surgical Science, Graduate School of Medicine, Gunma University, 3-39-22, Showamachi, Maebashi, 371-8511, Japan

    Takaomi Seki, Akira Watanabe, Norifumi Harimoto & Ken Shirabe

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  1. Takaomi Seki
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Correspondence to Norifumi Harimoto.

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Seki, T., Watanabe, A., Harimoto, N. et al. Systematic review of resectable intraductal tubulopapillary neoplasm with special reference to recurrence patterns. Surg Today 52, 532–541 (2022). https://doi.org/10.1007/s00595-021-02324-3

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