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Peeling of the internal limiting membrane (ILM) at the macula has been shown to improve visual outcomes in a number of diseases most notably large macular holes. Perhaps partly related to it being a surgically satisfying manoeuvre, its use has been extended to a wide variety of vitreoretinal indications, including more recently and controversially, primary rhegmatogenous retinal detachment (RRD). Previous studies have suggested that its use reduces postoperative epiretinal membrane (ERM) formation and may improve visual results, although these have largely been retrospective or small comparative but non-randomised studies [1,2,3,4,5]. In this issue, however, Eissa et al., report a randomised controlled study of ILM peeling in 43 eyes undergoing vitrectomy for macula involving retinal detachment and report a detrimental effect of ILM peeling [6]. Although there was a lower incidence of ERM in the ILM peel group, visual acuity and macular sensitivity were significantly better in the no peel group. The studies generalisability can be criticised in that silicone oil was used in all eyes despite all cases having less than C PVR based on lack of access to long acting gases. There was also a significantly longer duration of macula detachment in the peel group, and a significantly greater extent of retinal detachment in the non-peel group; however, neither of these differences were significant to final visual outcome on multivariate analysis.
Being the only randomised study to date on this subject, the findings of Eissa et al. deserve to be taken seriously. There are a number of possible explanations for the apparent detrimental effect of ILM peeling in this series.
ILM peeling is known to have a number of potentially adverse effects on retinal structural and function no matter how carefully performed, related to that fact that, when the ILM is peeled from the retinal surface, fragments of the underlying Muller cell end feet are avulsed with it [7]. Interestingly, the extent to which this occurs varies by disease, and a deeper plane of separation may have greater effects on retinal function. ILM examined from patients undergoing idiopathic ERM peeling have shown more Muller cell fragments, suggestive of a deeper plane of separation, than in those from macular hole specimens without ERM [8]. It is well known that in retinal detachment, Muller cell activation and elongation of their processes occurs not only towards the outer retina but also to, and through, the internal limiting membrane onto the retinal surface with ERM formation [9]. Forced avulsion of the ILM by peeling from the retinal surface in this situation would thus likely have a more profound effect on retinal structure and function than in a non-activated state. The extent of Muller cell activation is at least in part related to RRD duration, and it is significant that Eissa et al., observed a very marked dimpling of the retinal surface representing a severe ‘dissociated optic nerve fibre layer appearance’ (DONFL) in the ILM peeled group. Relevantly, DONFL severity has been related to the amount of Muller cell material avulsed during ILM peeling, and possibly to visual outcome in macular hole surgery [10]. It is also possible that ILM peeling in a detached retina is more traumatic per se than in attached retina related to surgical difficulty and variable angle of peel in a mobile retina [5]. Eissa et al., used BBG with a contact time of 30 s to stain the ILM and peeled without the use of heavy liquids to stabilise the retina as other authors have described [11].
Silicone oil was used in all cases in the RCT and oil related visual loss may have played a role in the outcomes. Although the pathogenesis of this enigmatic condition is unclear it has been consistently linked to changes in the inner retina [12,13,14]. ILM peeling would clearly increase oil/nerve fibre layer contact and the potential for a toxic effect. The incidence of oil related visual loss has also been recently linked with raised intraocular pressure, although pressure changes were not reported in the study [15].
The main benefit proposed for ILM peeling in RRD surgery has been a reduction of postoperative ERM with several studies reporting large differences [1,2,3,4], with high prevalence in the non-peeling groups. The incidence of ERM reported after retinal detachment varies widely depending on the definition used and case mix of the RRDs, but ERM, thought to have a significant visual effect, has typically been reported in ~4–8% of cases of uncomplicated RRD (i.e., without pre-existing PVR) treated with vitrectomy surgery [16, 17]. Eissa et al., observed that although there was a difference in the prevalence of ERM on postoperative OCTs in their study, none of the ERMs seen in the no peel group were clinically significant and none required further surgery. The clear question that arises is whether the potential morbidity of ILM peeling is warranted in uncomplicated RRD when the incidence of significant ERM is so low. Indeed, ERM can be peeled post RRD repair if required with good results (even without ILM peeling) [18].
ILM peeling in RRD can only be justified if it improves results. This RCT, albeit small and with a single surgeon suggests that it does not improve results in macula involving RRD without PVR tamponaded with silicone oil. Indeed, it had a deleterious effect on outcome. It may be it has a role in subsets of patients, e.g., those with PVR and those with macular on or just off cases. Further well-designed RCTs in macula attached and detached cases will be needed to answer this controversy definitively, but in the meantime we would suggest that it should not be regarded as standard practice.
References
Forlini M, Date P, Ferrari LM et al. (2017) Comparative analysis of retinal reattachment surgery with or without internal limiting membrane peeling to prevent postoperative macular pucker. https://doi.org/10.1097/IAE.0000000000001775
Akiyama K, Fujinami K, Watanabe K, Tsunoda K, Noda T (2016) Internal limiting membrane peeling to Prevent post-vitrectomy Epiretinal membrane development in retinal detachment. Am J Ophthalmol 171:1–10
Aras C, Arici C, Akar S et al (2009) Peeling of internal limiting membrane during vitrectomy for complicated retinal detachment prevents epimacular membrane formation. Graefes Arch Clin Exp Ophthalmol 247(5):619–623
Nam KY, Kim JY (2015) Effect of internal limiting membrane peeling on the development of epiretinal membrane after pars plana vitrectomy for primary rhegmatogenous retinal detachment. Retina 35:880–885
Hisatomi T, Tachibana T, Notomi S et al. (2017) Internal limiting membrane peeling-dependent retinal structural changes after vitrectomy in rhegmatogenous retinal detachment. Retina. https://doi.org/10.1097/IAE.0000000000001558
Eissa et al. Functional and Structural Outcomes of ILM Peeling in Uncomplicated Macula Off RRD Using Microperimetry & En-Face OCT. Graefes Arch Clin Exp Ophthalmol. https://doi.org/10.1007/s00417-017-3875-7
Chatziralli IP, Theodossiadis PG, Steel DHW. (2017) Internal limiting membrane peeling in macular hole surgery; why, when, and how? Retina. https://doi.org/10.1097/IAE.0000000000001959
Kenawy N, Wong D, Stappler T et al (2010) Does the presence of an epiretinal membrane alter the cleavage plane during internal limiting membrane peeling? Ophthalmology 117:320–323
Sethi CS, Lewis GP, Fisher SK et al (2005) Glial remodeling and neural plasticity in human retinal detachment with proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci 46:329–342
Steel DH, Dinah C, White K, Avery PJ (2017) The relationship between a dissociated optic nerve fibre layer appearance after macular hole surgery and Muller cell debris on peeled internal limiting membrane. Acta Ophthalmol 95:153–157
Höhn F, Kretz FT, Pavlidis M (2014) Primary vitrectomy with peeling of the internal limiting membrane under decaline: a promising surgical maneuver for treatment of total and subtotal retinal detachment. Ophthalmologe 111:882–886
Purtskhvanidze K, Hillenkamp J, Tode J et al (2017) Thinning of inner retinal layers after Vitrectomy with silicone oil versus gas Endotamponade in eyes with macula-off retinal detachment. Ophthalmologica 238:124–132
Christensen UC, la Cour M (2012) Visual loss after use of intraocular silicone oil associated with thinning of inner retinal layers. Acta Ophthalmol 90:733–737
Caramoy A, Droege KM, Kirchhof B, Fauser S (2014) Retinal layers measurements in healthy eyes and in eyes receiving silicone oil-based endotamponade. Acta Ophthalmol 92:292–297
Marti M, Walton R, Böni C, Zweifel SA, Stahel M, Barthelmes D. (2017) Increased intraocular pressure is a risk factor for unexplained visual loss during silicone oil endotamponade. Retina. https://doi.org/10.1097/IAE.0000000000001492
Martínez-Castillo V, Boixadera A, Distéfano L, Zapata M, García-Arumí J (2012) Epiretinal membrane after pars plana vitrectomy for primary pseudophakic or aphakic rhegmatogenous retinal detachment: incidence and outcomes. Retina 32:1350–1355
Heo MS, Kim HW, Lee JE, Lee SJ, Yun IH (2012) The clinical features of macular pucker formation after pars plana vitrectomy for primary rhegmatogenous retinal detachment repair. Korean J Ophthalmol 26:355–361
Council MD, Shah GK, Lee HC, Sharma S (2005) Visual outcomes and complications of epiretinal membrane removal secondary to rhegmatogenous retinal detachment. Ophthalmology 112:1218–1221
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Steel, D.H., Joussen, A.M. & Wong, D. ILM peeling in rhegmatogenous retinal detachment; does it improve the outcome?. Graefes Arch Clin Exp Ophthalmol 256, 247–248 (2018). https://doi.org/10.1007/s00417-017-3876-6
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DOI: https://doi.org/10.1007/s00417-017-3876-6