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Progress in multiple sclerosis research in the last year

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Abstract

Herein, we summarize the main articles describing novel findings in multiple sclerosis published in the Journal of Neurology over the last year, including clinical, therapeutic and research issues.

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References

  1. Chaudhuri A, Behan PO (2004) Fatigue in neurological disorders. Lancet 363:978–988

    Article  PubMed  Google Scholar 

  2. Yaldizli Ö, Glassl S, Sturm D, Papadopoulou A, Gass A, Tettenborn B, Putzki N (2011) Fatigue and progression of corpus callosum atrophy in multiple sclerosis. J Neurol 258:2199–2205

    Article  PubMed  Google Scholar 

  3. Morgante F, Dattola V, Crupi D, Russo M, Rizzo V, Ghilardi MF et al (2012) Is central fatigue in multiple sclerosis a disorder of movement preparation? J Neurol 258:263–272

    Article  Google Scholar 

  4. Horowski S, Zettl UK, Benecke R, Walter U (2012) Sonographic basal ganglia alterations are related to non-motor symptoms in multiple sclerosis. J Neurol 258:195–202

    Article  Google Scholar 

  5. Judica E, Martinelli Boneschi F, Ungaro D, Comola M, Gatti R, Comi G, Rossi P (2012) Impact of fatigue on the efficacy of rehabilitation in multiple sclerosis. J Neurol 258:835–839

    Article  Google Scholar 

  6. Sacco R, Bussman R, Oesch P, Kesselring J, Beer S (2012) Assessment of gait parameters and fatigue in MS patients during inpatient rehabilitation: a pilot trial. J Neurol 258:889–894

    Article  Google Scholar 

  7. Mori F, Ljoka C, Magni E, Codecà C, Kusayanagi H, Monteleone F et al (2011) Transcranial magnetic stimulation primes the effect of exercise therapy in multiple sclerosis. J Neurol 258:1281–1287

    Article  PubMed  Google Scholar 

  8. McNicholas N, Chataway J (2011) Relapse risk in patients with multiple sclerosis after H1N1 vaccination, with or without seasonal influenza vaccination. J Neurol 258:1545–1547

    Article  PubMed  Google Scholar 

  9. Wipfler P, Pilz G, Broussalis E, Golaszewski SM, Kunz A, Trinka E, Kraus J (2011) Acute pulmonary edema caused by a multiple sclerosis relapse. J Neurol 258:1176–1179

    Article  PubMed  CAS  Google Scholar 

  10. Valentino P, Nisticò R, Pirritano D, Bilotti G, Del Giudice F, Sturniolo M, Quattrone A (2011) Lamotrigine therapy for paroxysmal dysarthria caused by multiple sclerosis: a case report. J Neurol 258:1349–1350

    Article  PubMed  CAS  Google Scholar 

  11. Nociti V, Batocchi AP, Luigetti M, Conte A, Lorusso VS, Roiati S et al (2011) Progressive ascending myelopathy: atypical forms of multiple sclerosis or what else? J Neurol 258:1965–1970

    Article  PubMed  Google Scholar 

  12. Häne A, Bargetzi M, Hewer E, Bruehlmeier M, Khamis A, Roelcke U (2011) Recurrent tumefactive demyelination without evidence of multiple sclerosis or brain tumor. J Neurol 258:318–320

    Article  PubMed  Google Scholar 

  13. Morrow SA, Jurgensen S, Forrestal F, Munchauer FE, Benedict RHB (2012) Effects of acute relapses on neuropsychological status in multiple sclerosis patients. J Neurol 258:1603–1608

    Article  Google Scholar 

  14. Nocentini U, Pasqualetti P, Bonavita S, Buccafusca M, De Caro MF, Farina D et al (2006) Cognitive dysfunctions in patients with relapsing-remitting multiple sclerosis. Mult Scler 12:77–87

    Article  PubMed  CAS  Google Scholar 

  15. Akbar N, Honarmand K, Kou N, Feinstein A (2011) Validity of a computerized version of the Symbol Digit Modalities Test in multiple sclerosis. J Neurol 258:373–379

    Article  PubMed  Google Scholar 

  16. Honarmand K, Akbar N, Kou N, Feinstein A (2011) Predicting employment status in multiple sclerosis patients: the utility of the MS functional composite. J Neurol 258:244–249

    Article  PubMed  Google Scholar 

  17. Zaaraoui W, Reuter F, Rico A, Faivre A, Crespy L, Malikova I et al (2011) Occurrence of neuronal dysfunction during the first 5 years of multiple sclerosis is associated with cognitive deterioration. J Neurol 258:811–819

    Article  PubMed  Google Scholar 

  18. Reis A, Mateus C, Macário MC, Faria de Abreu JR, Castelo-Branco M (2011) Independent patterns of damage to retinocortical pathways in multiple sclerosis without a previous episode of optic neuritis. J Neurol 258:1695–1704

    Article  PubMed  Google Scholar 

  19. Healy B, Chitnis T, Engler D (2011) Improving power to detect disease progression in multiple sclerosis through alternative analysis strategies. J Neurol 258:1812–1819

    Article  PubMed  Google Scholar 

  20. Invernizzi P, Bertolasi L, Bianchi MR, Turatti M, Gajofatto A, Benedetti MD (2011) Prognostic value of multimodal evoked potentials in multiple sclerosis: the EP score. J Neurol 258:1933–1939

    Article  PubMed  Google Scholar 

  21. Jozefowicz-Korczynska M, Pajor AM (2011) Evaluation of the smooth pursuit tests in multiple sclerosis patients. J Neurol 258:1795–1800

    Article  PubMed  Google Scholar 

  22. Prochnow D, Donell J, Schäfer R, Jörgens S, Hartung HP, Franz M, Seitz RJ (2011) Alexithymia and impaired facial affect recognition in multiple sclerosis. J Neurol 258:1683–1688

    Article  PubMed  CAS  Google Scholar 

  23. Argyriou AA, Iconomou G, Ifanti AA, Karanasios P, Assimakopoulos K, Makridou A et al (2011) Religiosity and its relation to quality of life in primary caregivers of patients with multiple sclerosis: a case study in Greece. J Neurol 258:1114–1119

    Article  PubMed  Google Scholar 

  24. Malucchi S, Gilli F, Caldano M, Sala A, Capobianco M, di Sapio A et al (2011) One-year evaluation of factors affecting the biological activity of interferon beta in multiple sclerosis patients. J Neurol 258:895–903

    Article  PubMed  CAS  Google Scholar 

  25. Menge T, Hartung HP, Kieseier BC (2011) Neutralizing antibodies in interferon beta treated patients with multiple sclerosis: knowing what to do now. J Neurol 258:904–907

    Article  PubMed  Google Scholar 

  26. Zwibel H, Pardo G, Smith S, Denney D, Oleen-Burkey M (2011) A multicenter study of the predictors of adherence to self-injected glatiramer acetate for treatment of relapsing-remitting multiple sclerosis. J Neurol 258:402–411

    Article  PubMed  CAS  Google Scholar 

  27. Hellwig K, Gold R (2011) Glatiramer acetate and interferon-beta throughout gestation and postpartum in women with multiple sclerosis. J Neurol 258:502–503

    Article  PubMed  Google Scholar 

  28. Lebrun C, Vermersch P, Brassat D, Defer G, Rumbach L, Clavelou P et al (2011) Cancer and multiple sclerosis in the era of disease-modifying treatments. J Neurol 258:1304–1311

    Article  PubMed  Google Scholar 

  29. Havla J, Gerdes LA, Meinl I, Krumbholz M, Faber H, Weber F, Pellkofer HL et al (2011) De-escalation from natalizumab in multiple sclerosis: recurrence of disease activity despite switching to glatiramer acetate. J Neurol 258:1665–1669

    Article  PubMed  CAS  Google Scholar 

  30. Magraner MJ, Coret F, Navarré A, Boscá I, SimóM Escutia M et al (2011) Pulsed steroids followed by glatiramer acetate to prevent inflammatory activity after cessation of natalizumab therapy: a prospective, 6-month observational study. J Neurol 258:1805–1811

    Article  PubMed  Google Scholar 

  31. MacManus DG, Miller DH, Kappos L, Gold R, Havrdova E, Limmroth V et al (2011) BG-12 reduces evolution of new enhancing lesions to T1-hypointense lesions in patients with multiple sclerosis. J Neurol 258:449–456

    Article  PubMed  CAS  Google Scholar 

  32. Duddy M, Haghikia A, Cocco E, Eggers C, Drulovic J, Carmona O et al (2011) Managing MS in a changing treatment landscape. J Neurol 258:728–739

    Article  PubMed  Google Scholar 

  33. Fjeldstad AS, McDaniel J, Witman MAH, Ives SJ, Zhao J, Rose JW et al (2011) Vascular function and multiple sclerosis. J Neurol 258:2036–2042

    Article  PubMed  CAS  Google Scholar 

  34. Steffensen LH, Jørgensen L, Straume B, Ivar Mellgren S, Kampman MT (2011) Can vitamin D3 supplementation prevent bone loss in persons with MS? A placebo-controlled trial. J Neurol 258:1624–1631

    Article  PubMed  CAS  Google Scholar 

  35. Munger KL, Chitnis T, Frazier AL, Giovannucci E, Spiegelman D, Ascherio A (2011) Dietary intake of vitamin D during adolescence and risk of multiple sclerosis. J Neurol 258:479–485

    Article  PubMed  CAS  Google Scholar 

  36. Simon KC, Munger KL, Kraft P, Hunter DJ, De Jager PL, Ascherio A (2011) Genetic predictors of 25-hydroxyvitamin D levels and risk of multiple sclerosis. J Neurol 258:1676–1682

    Article  PubMed  CAS  Google Scholar 

  37. Koutsis G, Karadima G, Floroskufi P, Sfagos C, Vassilopoulos D, Panas M (2011) The rs10492972 KIF1B polymorphism and disease progression in Greek patients with multiple sclerosis. J Neurol 258:1726–1728

    Article  PubMed  Google Scholar 

  38. Aulchenko YS, Hoppenbrouwers IA, Ramagopalan SV, Broer L, Jafari N, Hillert J et al (2008) Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis. Nat Genet 40:1402–1403

    Article  PubMed  CAS  Google Scholar 

  39. Edwards LJ, Sharrack B, Ismail A, Tumani H, Constantinesku CS (2011) Central inflammation versus peripheral regulation in multiple sclerosis. J Neurol 258:1518–1527

    Article  PubMed  CAS  Google Scholar 

  40. Axelsson M, Malmeström C, Nilsson S, Haghighi S, Rosengren L, Lycke J (2011) Glial fibrillary acidic protein: a potential biomarker for progression in multiple sclerosis. J Neurol 258:882–888

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Daniela Galimberti.

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Galimberti, D., Scarpini, E. Progress in multiple sclerosis research in the last year. J Neurol 259, 1497–1501 (2012). https://doi.org/10.1007/s00415-012-6578-3

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  • DOI: https://doi.org/10.1007/s00415-012-6578-3

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