Abstract
Background
β2-Adrenergic receptor (β2AR), a G-protein coupled receptor, is present on the bronchial smooth muscle cells and results in bronchodilation upon activation. The genetic factors determining β2AR expression and function may not only alter the response of an individual to the therapy but also may serve as predictive markers for response to the agonists used in the therapy. The present study aimed at evaluating the role of β2AR-16 and β2AR-27 gene polymorphisms in asthma.
Methods
A case–control study was performed with a total of 824 adult subjects, including 410 asthmatics and 414 healthy controls from regions of North India. The β2AR-16 and β2AR-27 polymorphisms were genotyped by PCR–RFLP.
Results
Statistical analysis for the β2AR-16 polymorphism revealed that the mutant Gly16 allele was significantly associated with asthma, with OR = 0.80, 95 % CI = 0.65–0.99, and P = 0.032. The Gly16/Gly16 mutant genotype also confers decreased risk toward asthma, with OR = 0.65, 95 % CI = 0.41–1.02, and P = 0.049. However, the β2AR-27 polymorphism was not associated with asthma as it did not reach statistical significance, with OR = 0.86, 95 % CI = 0.69–1.07, and P = 0.163.
Conclusion
The β2AR-16 polymorphism confers a decreased risk toward asthma while the β2AR-27 polymorphism is not associated with asthma in the studied North Indian population.
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Acknowledgments
J. Singh is grateful to the University Grants Commission, New Delhi, India, for providing Grant support for the study [UGC Grant F. No. 40-161/2011 (SR)]. The University Grants Commission, New Delhi, India, is a government organization that funds studies in the universities across the country to promote research and is not affected by the outcomes of this study in any way.
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Birbian, N., Singh, J., Jindal, S.K. et al. Association of β2-Adrenergic Receptor Polymorphisms with Asthma in a North Indian Population. Lung 190, 497–504 (2012). https://doi.org/10.1007/s00408-012-9407-7
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DOI: https://doi.org/10.1007/s00408-012-9407-7