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I-scan combined with laryngovideostroboscopy for predicting malignancy in vocal fold leukoplakia

  • Laryngology
  • Published:
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Abstract

Objective

This study evaluated vocal fold leukoplakia using i-scan combined with laryngovideostroboscopy for risk assessment prediction.

Methods

A total of 141 patients with 218 lesions were enrolled in this study. Morphological characteristics of leukoplakia, assessment of the vascular pattern using i-scan, and vocal fold vibratory function were analyzed.

Results

The number of patients with no, mild, moderate, severe dysplasia, and invasive carcinoma were 68, 40, 17, 46 and 47, respectively. The sensitivity of morphological characteristic, vascular pattern, vibratory function and predictive model were 77.4%, 72%, 69.9%, and 82.8%, respectively. Receiver operating characteristic curve analysis of morphological characteristic, vascular pattern, vibratory function and predictive model were 0.771, 0.824, 0.769, and 0.923, respectively. The results of logistic regression analysis showed that rough morphological types, perpendicular vascular pattern, severe decrease and absence of mucosal waves increased the risk of malignancy (OR = 5.531, 4.973, and 16.992, respectively; P < 0.001).

Conclusions

I-scan combined with laryngovideostroboscopy can improve the differential diagnosis of low-risk and high-risk vocal fold leukoplakia.

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Data availability

The data are available from the corresponding author on reasonable request.

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Funding

This work was supported by grant from the Fundamental Research Funds for the Central Universities, Grant no. 2021FZZX005-07.

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Author notes

  1. Qi Wang and Yi Ling have contributed to the work equally and should be regarded as co-first authors.

Authors and Affiliations

  1. Department of Otolaryngology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Jie Fang Road 88, Hangzhou, 310000, Zhejiang, China

    Qi Wang, Yi Ling, Yang-Yi-Yi Huang, Lin-Rong Li, Lei Shen, Jian Zhang & Guo-Kang Fan

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  1. Qi Wang
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  2. Yi Ling
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Corresponding author

Correspondence to Guo-Kang Fan.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

We conducted the presented study in accordance with the guidelines of the Declaration of Helsinki (Washington, World Medical Association, 2010). This study was approved by the Institutional Review Board of Second Affiliated Hospital of Zhejiang University School of Medicine (2022-1160).

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In accordance with the vote of the ethics committee, no contact with the patients was necessary in the performed retrospective study.

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Wang, Q., Ling, Y., Huang, YYY. et al. I-scan combined with laryngovideostroboscopy for predicting malignancy in vocal fold leukoplakia. Eur Arch Otorhinolaryngol 281, 1409–1416 (2024). https://doi.org/10.1007/s00405-023-08390-2

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