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The role of narrow-band imaging (NBI) endoscopy in optical biopsy of vocal cord leukoplakia

  • Laryngology
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Abstract

The aim of this study was to investigate whether observing microvascular changes by narrow-band imaging (NBI) endoscopy in the area surrounding leukoplakia is sufficient for discriminating between benign and malignant patterns of vocal cord leukoplakia. A total of 282 patients were investigated using white-light high-definition TV laryngoscopy and NBI endoscopy from 6/2013 to 8/2015, and 63 patients with a primary case of laryngeal leukoplakia were enrolled. Patients were divided into two groups based on leukoplakia with surrounding malignant intraepithelial papillary capillary loops (group I; 26/63) and leukoplakia with a surrounding benign vascular network (group II; 37/63), both by NBI endoscopy. All 63 patients were evaluated by blinded histological examination, and results were compared with NBI optical biopsy. Carcinoma in situ or invasive squamous cell carcinoma was confirmed in 22/26 cases (84.6 %) in group I. Hyperkeratosis or low-grade dysplasia was confirmed histologically in 31/37 (83.8 %) and squamous cell carcinoma in 2/37 (5.4 %) cases in group II. Accordance of NBI endoscopy and histopathological features of vocal cord leukoplakia lesions was statistically significant (kappa index 0.77, p < 0.001), with a sensitivity of 88.0 % (95 % CI 67.8–97.5 %) and specificity of 89.5 % (95 % CI 71.2–97.1 %). NBI is convenient for improving evaluation of laryngeal leukoplakias based on optic prehistological diagnosis. The close accordance between NBI features and histological results suggests that a negative NBI endoscopy may be an indication for long-term endoscopy follow-up without histological evaluation.

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Acknowledgments

The authors would like to thank MSc. Ing. Hana Tomášková, Ph. D. from the Institute of Epidemiology and Public Health, Medical Faculty of the Ostrava University, Czech Republic, for her help with statistical analysis.

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Authors and Affiliations

  1. Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Ostrava, 17. listopadu 1790, 708 52, Ostrava, Czech Republic

    L. Staníková, H. Kučová, R. Walderová, K. Zeleník & Pavel Komínek

  2. Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine in Hradec Králové, University Hospital Hradec Králové, Charles University in Prague, Prague, Czech Republic

    J. Šatanková

  3. Department of Craniofacial Surgery, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic

    K. Zeleník & Pavel Komínek

Authors
  1. L. Staníková
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  2. J. Šatanková
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  3. H. Kučová
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  4. R. Walderová
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  5. K. Zeleník
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  6. Pavel Komínek
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Corresponding author

Correspondence to Pavel Komínek.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

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The authors declare that there is no actual or potential conflict of interest in relation to this article. No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.

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Staníková, L., Šatanková, J., Kučová, H. et al. The role of narrow-band imaging (NBI) endoscopy in optical biopsy of vocal cord leukoplakia. Eur Arch Otorhinolaryngol 274, 355–359 (2017). https://doi.org/10.1007/s00405-016-4244-6

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  • DOI: https://doi.org/10.1007/s00405-016-4244-6

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