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Histopathological effects of septoplasty techniques on nasal septum mucosa: an experimental study

  • Rhinology
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Abstract

Objective

The aim of this study is to evaluate the histopathological effects of septoplasty techniques on the nasal septal mucosa of rabbits with light and electron microscope.

Methods

The study was performed on 21 rabbits between August 2016 and February 2017. Rabbits were randomly divided into three groups. In Group-1, while preserving the L-strut structure of the septum, cartilage resection, was performed by open technique septoplasty. In Group-2, the same procedure was done except the resected cartilage was crushed and put back in place. No surgical procedure was performed on the Control group. Postoperative 2nd month; the specimens were histopathologically evaluated by light and electron microscope in terms of changes in the morphology of septum mucosa, perichondrial thickness, cilia and goblet cell deprivation, loss in glands, fibrosis and inflammatory cell infiltration in the lamina propria.

Results

The deprivation in cilia, goblet cells, serous gland and increase in the amount of collagen fibers were examined in both Group-1 and 2. The difference in Group-1 and Group-2 were statistically significant in terms of presence of cilia, number of goblet cells and glands and increase in collagen fibers when compared to control (p < 0.001, p = 0.002, p = 0.020, p = 0.002, respectively). In terms of perichondrium thickness, statistically significant difference was found between the Control and Group-2 (p < 0.001).

Conclusıon

In this study, histopathological findings supported that the presence of cartilage in the septum is necessary to prevent the mucosal changes. Long-term studies are needed to observe whether changes in the morphology of epithelium and gland proceed more than 2 months follow-up.

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Authors and Affiliations

  1. Ankara Gölbaşı Şehit Ahmet Özsoy State Hospital ENT, Bahçelievler Mahallesi, 321. Sk. No: 2, 06830, Gölbaşı, Ankara, Turkey

    Semih Ozdemir

  2. Otorhinolaryngology Department, Health Sciences University Ankara Training and Research Hospital, Sakarya Mh. Ulucanlar Cd. No: 89, 06230, Altındağ, Ankara, Turkey

    Hatice Celik & Necmi Aslan

  3. Bozok University faculty of Medicine ENT Department, Medrese Mahallesi Adnan Menderes Bulvarı No: 118, 66200, Yozgat, Turkey

    Ceyhun Cengiz

  4. Department of Histology and Embryology, Hacettepe University, 06100, Ankara, Turkey

    Naciye Dilara Zeybek & Elham Bahador

Authors
  1. Semih Ozdemir
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  2. Hatice Celik
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  3. Ceyhun Cengiz
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  4. Naciye Dilara Zeybek
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  5. Elham Bahador
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  6. Necmi Aslan
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Corresponding author

Correspondence to Hatice Celik.

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Conflict of interest

The authors do not have any conflicts of interest. No financial support was obtained for this study.

Ethical approval

The study was conducted after the approval of Animal Experiments Ethical Committee of our Hospital (date:Aug 16, 2016-decree no: 0034/438).

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Ozdemir, S., Celik, H., Cengiz, C. et al. Histopathological effects of septoplasty techniques on nasal septum mucosa: an experimental study. Eur Arch Otorhinolaryngol 276, 421–427 (2019). https://doi.org/10.1007/s00405-018-5226-7

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  • DOI: https://doi.org/10.1007/s00405-018-5226-7

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