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The impact of tissue glue in wound healing of head and neck patients undergoing neck dissection

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Abstract

We investigated the impact of fibrin glue on postoperative drainage amount and duration in head and neck cancer patients who underwent neck dissection. This study was a prospective randomized controlled trial. Patients who were scheduled to undergo neck dissection due to head and neck cancer were eligible for this study. After receiving a detailed explanation, all patients signed an informed consent form before enrollment. Patients were then randomly assigned to the study group (fibrin glue) or control group. In the study group, 2 ml of fibrin glue (Tissucol®; Duploject, Baxter AG) was applied on the surface of the surgical wound before closure. Basic demographic data along with tumor-related features, operation-related variables, postoperative drainage amount/duration, postoperative pain, and analgesic usage were collected and analyzed. A total of 15 patients were included in the final analyses, with eight patients in the study group and seven patients in the control group. No significant differences were found between the two groups in age, gender, primary site, clinical N stage, neck dissection levels, perioperative bleeding, postoperative drainage amount/duration, hospitalization duration, and postoperative pain status. The application of 2 ml fibrin glue by the method described herein did not reduce the postoperative drainage amount/duration nor the postoperative pain status in patients who underwent neck dissection.

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Acknowledgments

The authors thank the Biostatistics Task Force of Taichung Veterans General Hospital for their assistance with the statistical analysis. This study was supported by a grant from Taichung Veterans General Hospital (TCVGH-1027003C) Taichung, Taiwan, Republic of China.

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Authors and Affiliations

  1. Department of Otolaryngology, Taichung Veterans General Hospital, No. 1650, Sec 4, Taiwan Boulevard, Taichung, Taiwan

    Che-Wei Huang, Chen-Chi Wang, Rong-San Jiang, Yu-Chia Huang & Shih-An Liu

  2. Department of Medical Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan

    Hui-Ching Ho

  3. Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan

    Chen-Chi Wang & Shih-An Liu

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  1. Che-Wei Huang
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  2. Chen-Chi Wang
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  4. Yu-Chia Huang
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Correspondence to Shih-An Liu.

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Huang, CW., Wang, CC., Jiang, RS. et al. The impact of tissue glue in wound healing of head and neck patients undergoing neck dissection. Eur Arch Otorhinolaryngol 273, 245–250 (2016). https://doi.org/10.1007/s00405-015-3709-3

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  • DOI: https://doi.org/10.1007/s00405-015-3709-3

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