Abstract
Purpose
To assess adverse pregnancy outcomes in patients complicated with mild or severe Hyperemesis Gravidarum (HG).
Methods
A retrospective cohort study of women aged 18–45 with a singleton pregnancy that were admitted to the gynecological ward at the Soroka University Medical Center due to HG between the years 2013–2016 and gave birth at the same hospital was conducted. During the study period 89 patients met the inclusion criteria and comprised the study group. Women without HG who gave birth at the same time period comprised the comparison group (n = 91). Univariate analysis was carried out using Chi square or Fisher's exact test for nominal variables, and T test for numeric variables. Significance was defined as a P value < 0.05.
Results
Women with HG were more likely to have experienced HG in a previous pregnancy. Rate of amniotic fluid abnormalities was significantly lower in the study group. However, rates of all other pregnancy complications were comparable between the groups. A sub-analysis of the HG group comparing mild and severe cases demonstrated no significant differences in rates of adverse pregnancy outcomes between the groups.
Conclusions
In this retrospective cohort study no association was demonstrated between HG and adverse pregnancy outcomes regardless of HG severity. Women with severe nausea and vomiting during pregnancy can be reassured that HG is not associated with unfavorable maternal and neonatal outcomes.
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Acknowledgements
The authors report no sources of support for the work. This study was conducted as part of the requirements for MD degree from the Goldman Medical School at the Faculty of Health Sciences, Ben-Gurion University of the Negev.
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Niv Agmon: protocol development, data collection, data analysis, manuscript writing. Shanny Sade: protocol development, data collection, manuscript writing. Gali Pariente: protocol development, data collection, data analysis, manuscript editing. Reut Rotem: protocol development, data analysis, manuscript editing. Adi Yehuda Weintraub: protocol development, data collection, data analysis, manuscript editing.
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Agmon, N., Sade, S., Pariente, G. et al. Hyperemesis gravidarum and adverse pregnancy outcomes. Arch Gynecol Obstet 300, 347–353 (2019). https://doi.org/10.1007/s00404-019-05192-y
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DOI: https://doi.org/10.1007/s00404-019-05192-y