Abstract
Introduction
Stiffness and decreased range of motion frequently lead to hindrance of activities of daily living and dissatisfaction follow total knee arthroplasty (TKA). This study aims to evaluate the effect of non-aspirin (ASA) chemoprophylaxis and determine patient-related risk factors for stiffness and need for manipulation under anesthesia (MUA) following primary TKA.
Materials and methods
A review of all patients undergoing primary TKA from 2013 to 2019 at a single academic orthopedic hospital was conducted. The primary outcome measure was MUA performed post-operatively. Chi-square analysis and Mann–Whitney U test were used to determine statistically significant relationships between risk factors and outcomes. Significance was set at p < 0.05. Univariate logistic regression was performed to control for identified independent risk factors for MUA.
Results
A total of 11,550 patients undergoing primary TKA from January 2013 to September 2019 at an academic medical center were included in the study. Increasing age and Charlson Comorbidity Index were associated with statistically significant decreased odds of MUA (0.93, 95% CI: 0.92–0.94, p < 0.001, OR 0.71, 95% CI 0.63–0.79, p < 0.001). Active smokers had a 2.01 increased odds of MUA (OR 2.01, 95% CI 1.28, 3.02, p < 0.001). There was no significant difference in rates of MUA between ASA and non-ASA VTE prophylaxis (p 0.108).
Conclusions
Younger age, lower CCI, and history of smoking are associated with a higher rate, while different chemical VTE prophylaxis does not influence rate of MUA after TKA. Arthroplasty surgeons should consider these risk factors when counseling patient preoperatively. Understanding each patients’ risk for MUA allows surgeons to appropriately set preoperative expectations and reasonable outcome goals.
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References
Azboy I, Barrack R, Thomas AM, Haddad FS, Parvizi J (2017) Aspirin and the prevention of venous thromboembolism following total joint arthroplasty: commonly asked questions. Bone Joint J 99-B(11):1420–1430
Bawa HS, Wera GD, Kraay MJ, Marcus RE, Goldberg VM (2013) Predictors of range of motion in patients undergoing manipulation after TKA. Clin Orthop Relat Res 471(1):258–263
Bierke S, Petersen W (2017) Influence of anxiety and pain catastrophizing on the course of pain within the first year after uncomplicated total knee replacement: a prospective study. Arch Orthop Trauma Surg 137(12):1735–1742
Bong MR, Di Cesare PE (2004) Stiffness after total knee arthroplasty. J Am Acad Orthop Surg 12(3):164–171
Bozic KJ, Vail TP, Pekow PS, Maselli JH, Lindenauer PK, Auerbach AD (2010) Does aspirin have a role in venous thromboembolism prophylaxis in total knee arthroplasty patients? J Arthroplast 25(7):1053–1060
Christensen CP, Crawford JJ, Olin MD, Vail TP (2002) Revision of the stiff total knee arthroplasty. J Arthroplast 17(4):409–415
Deirmengian GK, Heller S, Smith EB, Maltenfort M, Chen AF, Parvizi J (2016) Aspirin can be used as prophylaxis for prevention of venous thromboembolism after revision hip and knee arthroplasty. J Arthroplast 31(10):2237–2240
Desai AS, Karmegam A, Dramis A, Board TN, Raut V (2014) Manipulation for stiffness following total knee arthroplasty: when and how often to do it? Eur J Orthop Surg Traumatol 24(7):1291–1295
Faour M, Piuzzi NS, Brigati DP et al (2018) Low-dose aspirin is safe and effective for venous thromboembolism prophylaxis following total knee arthroplasty. J Arthroplast 33(7S):S131–S135
Feng JE, Anoushiravani AA, Ziegler J, Schwarzkopf R, Long WJ (2019) Manipulation under anesthesia: does polyethylene thickness matter? J Knee Surg 32(11):1088–1093
Fitzsimmons SE, Vazquez EA, Bronson MJ (2010) How to treat the stiff total knee arthroplasty?: a systematic review. Clin Orthop Relat Res 468(4):1096–1106
Fox JL, Poss R (1981) The role of manipulation following total knee replacement. J Bone Joint Surg Am 63(3):357–362
Geerts WH, Bergqvist D, Pineo GF et al (2008) Prevention of venous thromboembolism: American college of chest physicians evidence-based clinical practice guidelines (8th edition). Chest 133(6 Suppl):381S-453S
Gonzalez Della Valle A, Leali A, Haas S (2007) Etiology and surgical interventions for stiff total knee replacements. HSS J 3(2):182–189
Huang RC, Parvizi J, Hozack WJ, Chen AF, Austin MS (2016) Aspirin is as effective as and safer than warfarin for patients at higher risk of venous thromboembolism undergoing total joint arthroplasty. J Arthroplast 31(9 Suppl):83–86
Issa K, Banerjee S, Kester MA, Khanuja HS, Delanois RE, Mont MA (2014) The effect of timing of manipulation under anesthesia to improve range of motion and functional outcomes following total knee arthroplasty. J Bone Joint Surg Am 96(16):1349–1357
Issa K, Kapadia BH, Kester M, Khanuja HS, Delanois RE, Mont MA (2014) Clinical, objective, and functional outcomes of manipulation under anesthesia to treat knee stiffness following total knee arthroplasty. J Arthroplast 29(3):548–552
Issa K, Rifai A, Boylan MR, Pourtaheri S, McInerney VK, Mont MA (2015) Do various factors affect the frequency of manipulation under anesthesia after primary total knee arthroplasty? Clin Orthop Relat Res 473(1):143–147
Izant T. H. T-NS, and Wagner J (2019) Risk Factors Associated With Manipulation Under Anaesthesia After Total Knee Arthroplasty. Orthopaedic Proceedings (B:Supp):101
Kahlenberg CA, Richardson SS, Schairer WW, Sculco PK (2018) Type of anticoagulant used after total knee arthroplasty affects the rate of knee manipulation for postoperative stiffness. J Bone Joint Surg Am 100(16):1366–1372
Kim J, Nelson CL, Lotke PA (2004) Stiffness after total knee arthroplasty. Prevalence of the complication and outcomes of revision. J Bone Joint Surg Am 86(7):1479–1484
Knapp P, Weishuhn L, Pizzimenti N, Markel DC (2020) Risk factors for manipulation under anaesthesia after total knee arthroplasty. Bone Joint J 102-B(6 Supple A):66–72
Lange JK, Lee YY, Spiro SK, Haas SB (2018) Satisfaction rates and quality of life changes following total knee arthroplasty in age-differentiated cohorts. J Arthroplast 33(5):1373–1378
Laubenthal KN, Smidt GL, Kettelkamp DB (1972) A quantitative analysis of knee motion during activities of daily living. Phys Ther 52(1):34–43
Lotke PA, Lonner JH (2006) The benefit of aspirin chemoprophylaxis for thromboembolism after total knee arthroplasty. Clin Orthop Relat Res 452:175–180
Newman ET, Herschmiller TA, Attarian DE, Vail TP, Bolognesi MP, Wellman SS (2018) Risk factors, outcomes, and timing of manipulation under anesthesia after total knee arthroplasty. J Arthroplast 33(1):245–249
Nicholls DW, Dorr LD (1990) Revision surgery for stiff total knee arthroplasty. J Arthroplast 5(Suppl):S73-77
Pariente GM, Lombardi AV Jr, Berend KR, Mallory TH, Adams JB (2006) Manipulation with prolonged epidural analgesia for treatment of TKA complicated by arthrofibrosis. Surg Technol Int 15:221–224
Schurman DJ, Parker JN, Ornstein D (1985) Total condylar knee replacement. A study of factors influencing range of motion as late as two years after arthroplasty. J Bone Joint Surg Am 67(7):1006–1014
Skrejborg P, Petersen KK, Kold S et al (2019) Presurgical comorbidities as risk factors for chronic postsurgical pain following total knee replacement. Clin J Pain 35(7):577–582
Walton NP, Jahromi I, Dobson PJ, Angel KR, Lewis PL, Campbell DG (2005) Arthrofibrosis following total knee replacement; does therapeutic warfarin make a difference? Knee 12(2):103–106
Yercan HS, Sugun TS, Bussiere C, Ait Si Selmi T, Davies A, Neyret P (2006) Stiffness after total knee arthroplasty: prevalence, management and outcomes. Knee 13(2):111–117
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Kirschner, N., Anil, U., Shah, A. et al. Role of non-ASA VTE prophylaxis in risk for manipulation following primary total knee arthroplasty. Arch Orthop Trauma Surg 143, 2135–2140 (2023). https://doi.org/10.1007/s00402-022-04488-0
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DOI: https://doi.org/10.1007/s00402-022-04488-0