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Synthesis and characterization of thermoresponsive hydrogels cross-linked with acryloyloxyethylaminopolysuccinimide

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Abstract

Biodegradable cross-linkers acryloyloxyethylaminopolysuccinimide (AEA-PSI) were obtained by microwave irradiation using maleic anhydride as materials. With AEA-PSI cross-linker, cross-linked poly(N-isopropylacrylamide-co-acrylic acid) [P(NIPAAm-co-AAc)] hydrogels were prepared, and their phase transition behavior, lower critical solution temperature (LCST), water content, thermodynamics stability, and enzymatic degradation properties were investigated. By alternating the NIPAAm/AAc molar ratio, hydrogels were synthesized to have LCST in the vicinity of 37 °C. The LCST of AEA-PSI-cross-linked P(NIPAAm-co-AAc) hydrogels was significantly influenced by monomer ratio of the NIPAAm/AAc but not by the cross-linking density within the polymer network. The water content of AEA-PSI-cross-linked P(NIPAAm-co-AAc) hydrogels was more than 90% even at 37 °C, which was controlled by the monomer molar ratio of NIPAAm/AAc, swelling media, and the cross-linking density. The thermodynamics stability was also characterized by thermogravimetry. In enzymatic degradation studies, breakdown of the AEA-PSI-cross-linked P(NIPAAm-co-AAc) hydrogels was dependent on the cross-linking density.

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Acknowledgment

This research was supported by the National Natural Science Foundation of China (No. 20476049); the Program for New Century Excellent Talents in Universities (No. NCET-04-0649); and the Science Foundation of Shandong Province (Y2006B10).

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Authors and Affiliations

  1. College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, People’s Republic of China

    Yue-qin Yu, Zhong-zhen Li, Hong-jie Tian & Shu-sheng Zhang

  2. College of Life Science and Pharmacy, Nanjing University of Technology, Nanjing, 210009, People’s Republic of China

    Yue-qin Yu & Ping-kai Ouyang

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  1. Yue-qin Yu
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  2. Zhong-zhen Li
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  3. Hong-jie Tian
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  4. Shu-sheng Zhang
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  5. Ping-kai Ouyang
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Correspondence to Shu-sheng Zhang.

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Submitted to Colloid and Polymer Science, 2007-1-28.

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Yu, Yq., Li, Zz., Tian, Hj. et al. Synthesis and characterization of thermoresponsive hydrogels cross-linked with acryloyloxyethylaminopolysuccinimide. Colloid Polym Sci 285, 1553–1560 (2007). https://doi.org/10.1007/s00396-007-1725-6

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  • DOI: https://doi.org/10.1007/s00396-007-1725-6

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