Abstract
Purpose
A cohort study was carried out to analyse quality indicators in the diagnosis and treatment of rectal carcinoma.
Methods
A total of 2,470 patients with rectal carcinoma treated between 1985 and 2007 at the Department of Surgery, University of Erlangen, were analysed and compared within four time intervals.
Results
Most of the indicators analysed from 2004 to 2007 fulfilled the defined target values. The indicators for process quality of surgical treatment and the surrogate indicators of outcome quality in surgery showed excellent results. Comparing this to previous data, it displays the new developments such as introduction of multimodal treatment for high-risk patients. While the rate of locoregional recurrences decreased, no significant improvement in survival was found.
Conclusions
Careful analysis of quality indicators is important for both quality management and comparison of treatment results. The progress in diagnosis and treatment requires a continuous update of definitions and target values.
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References
Soreide O, Norstein J, Fielding LP, Silen W (1997) International standardization and documentation of the treatment of rectal cancer. In: Soreide O, Norstein J (eds) Rectal Cancer Surgery. Optimisation–standardisation–documentation. Springer, Berlin, pp 405–445
Schmiegel W, Pox C, Adler G, Fleig W, Fölsch UR, Frühmorgen P, Graeven U, Hohenberger W, Holstege A, Junginger T, Kühlbacher T, Porschen R, Propping P, Riemann JF, Sauer R, Sauerbruch T, Schmoll HJ, Zeitz M, Selbmann HK (2004) S3-Leitlinienkonferenz “Kolorektales Karzinom” 2004. Z Gastroenterol 42:1129–1177
Schmiegel W, Reinacher-Schick A, Arnold D, Graeven U, Heinemann V, Porschen R, Riemann J, Rödel C, Sauer R, Wieser M, Schmitt W, Schmoll HJ, Seufferlein T, Kopp I, Pox C (2008) S3-Leitlinie „Kolorektales Karzinom“—Aktualisierung 2008. Z Gastroenterol 46:799–840
Bittner R, Burghardt J, Gross E, Grundmann RT, Hermanek P, Isbert C, Junginger T, Köckerling F, Merkel S, Möslein G, Raab HR, Roder J, Ruf G, Schwenk W, Strassburg J, Tannapfel A, de Vries A, Zühlke H (2007) Qualitätsindikatoren bei Diagnostik und Therapie des Rektumkarzinoms. Zentralblatt für Chirurgie 132:85–94
Sobin LH, Wittekind Ch (eds) UICC (2002): TNM classification of malignant tumours, 6th edn. Wiley, New York
UICC (2003) TNM Supplement. In: Wittekind Ch, Greene FL, Henson DE, Hutter RVP, Sobin LH (eds) A commentary on uniform use, 3rd edn. Wiley–Liss, New York
Heald RJ, Husband EM, Ryall RD (1982) The mesorectum in rectal cancer surgery—the clue to pelvic recurrence? Br J Surg 69:613–616
Compton CC (2002) Pathologic prognostic factors in the recurrence of rectal cancer. Clin Colorectal Cancer 2:149–160
Hermanek P, Hermanek P, Hohenberger W, Klimpfinger M, Köckerling F, Papadopoulos T (2003) The pathological assessment of mesorectal excision: implications for further treatment and quality management. Int J Colorectal Dis 18:335–341
Maughan NJ, Quirke P (2003) Modern management of colorectal cancer—a pathologist’s view. Scand J Surg 92:11–19
Nagtegaal ID, van de Velde CJH, Marijnen CAM, van Krieken JHJM, Quirke P (2005) Low rectal cancer: a call for a change of approach in abdominoperineal resection. J Clin Oncol 23:9257–9264
Glynne-Jones R, Mawdsley S, Novell JR (2006) The clinical significance of the circumferential resection margin following preoperative pelvic chemo-radiotherapy in rectal cancer: why we need a common language. Colorectal Dis 8:800–807
Junginger T, Kneist W, Sultanov F, Heintz A (2003) Qualitätsindikatoren der chirurgischen Therapie des Rektumkarzinoms. Chirurg 74:444–451
Steinert R, Marusch F, Koch A, Ptok H, Reymond MA, Gastinger I (2005) Möglichkeiten der Qualitätsverbesserung bei der Therapie des Rektumkarzinoms. Zentralbl Chir 130:387–392
Lippert H, Gastinger I (2006) Versorgung von Patienten mit Rektumkarzinomen in Deutschland. Deutsches Ärzteblatt 103:A2704–A2709
Ptok H, Marusch F, Kuhn R, Gastinger I, Lippert H (2007) Influence of hospital volume on the frequency of abdominoperineal resection and long-term oncological outcomes in low rectal cancer. Eur J Surg Oncol 33:854–861
Benchmarking Darmzentren WDC. Bericht 1. Halbjahr 2007. Available via: http://www.brustcentrum.de/doc/controls/document/docrender.aspx?ID=96. Accessed 15 Jan 2009
Luna-Pérez P, Rodríguez-Ramírez S, Alvarado I, Gutiérrez de la Barrera M, Labastida S (2003) Prognostic significance of retrieved lymph nodes per specimen in resected rectal adenocarcinoma after preoperative chemoradiation therapy. Arch Med Res 34:281–286
Hermanek P (1994) Hermanek P, Marzoli GP. In: Hermanek P, Marzoli GP (eds) Lokale Therapie des Rektumkarzinoms in kurativer Intention. Springer, Berlin, pp 7–19
Sengupta S, Tjandra JJ (2001) Local excision of rectal cancer: what is the evidence? Dis Colon Rectum 44:1345–1361
Matzel KE, Merkel S, Hohenberger W (2003) Lokale Therapieprinzipien beim Rektumkarzinom. Chirurg 74:897–904
Borschitz T, Gockel I, Kiesslich R, Junginger T (2008) Oncological outcome after local excision of rectal carcinomas. Ann Surg Oncol 15:3101–3108
Bittorf B, Stadelmaier U, Göhl J, Hohenberger W, Matzel KE (2004) Functional outcome after intersphincteric resection of the rectum with coloanal anastomosis in low rectal cancer. Eur J Surg Oncol 30:260–265
Gervaz P, Bucher P, Konrad B, Morel P, Beyeler S, Lataillade L, Allal A (2008) A prospective longitudinal evaluation of quality of life after abdominoperineal resection. J Surg Oncol 97:14–19
Schmidt O, Merkel S, Hohenberger W (2003) Anastomotic leakage after low rectal stapler anastomosis: significance of intraoperative anastomotic testing. Eur J Surg Oncol 29:239–243
Bittorf B, Stadelmaier U, Merkel S, Hohenberger W, Matzel KE (2003) Does anastomotic leakage affect functional outcome after rectal resection for cancer? Langenbecks Arch Surg 387:406–410
Merkel S, Wang WY, Schmidt O, Dworak O, Wittekind C, Hohenberger W, Hermanek P (2001) Locoregional recurrence in patients with anastomotic leakage after anterior resection for rectal carcinoma. Colorectal Dis 3:154–160
Sauer R, Becker H, Hohenberger W, Rödel C, Wittekind C, Fietkau R, Martus P, Tschmelitsch J, Hager E, Hess CF, Karstens JH, Liersch T, Schmidberger H, Raab R, German Rectal Cancer 29. Study Group (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351:1731–1740
Merkel S, Mansmann U, Siassi M, Papadopoulos T, Hohenberger W, Hermanek P (2001) The prognostic inhomogeneity in pT3 rectal carcinomas. Int J Colorectal Dis 16:298–304
Zirngibl H, Husemann B, Hermanek P (1990) Intraoperative spillage of tumor cells in surgery of rectal cancer. Dis Colon Rectum 33:610–614
Nagtegaal ID, van de Velde CJ, van der Worp E, Kapiteijn E, Quirke P, van Krieken JH, Cooperative Clinical Investigators of the Dutch Colorectal Cancer Group (2002) Macroscopic evaluation of rectal cancer resection specimen: clinical significance of the pathologist in quality control. J Clin Oncol 20:1729–1734
Maslekar S, Sharma A, Macdonald A, Gunn J, Monson JR, Hartley JE (2007) Mesorectal grades predict recurrences after curative resection for rectal cancer. Dis Colon Rectum 50:168–175
Quirke P, Guillou P, Thorpe H et al (2006) Circumferential margins in rectum and right colon in the MRC CLASSIC trial: 3 year disease free survival and local recurrence. J Pathol 208:30A
Nagtegaal ID, Quirke P (2008) What is the role for the circumferential margin in the modern treatment of rectal cancer? J Clin Oncol 26:303–312
Strassburg J, Junginger T, Trinh T, Püttcher O, Oberholzer K, Heald RJ, Hermanek P (2008) Magnetic resonance imaging (MRI)-based indication for neoadjuvant treatment of rectal carcinoma and the surrogate endpoint CRM status. Int J Colorectal Dis 23:1099–1107
Merkel S, Meyer T, Göhl J, Hohenberger W (2002) Late locoregional recurrence in rectal carcinoma. Eur J Surg Oncol 28:716–722
EUROCARE Homepage. Available via: http://www.eurocare.it/. Accessed 31 Mar 2009
SEER Homepage. Available via: http://seer.cancer.gov/index.html. Accessed 31 Mar 2009
Deutsche Krebsgesellschaft e. V. (2009) Erhebungsbogen für Darmzentren der Deutschen Krebsgesellschaft. Available via: http://www.krebsgesellschaft.de/download/eb_darm-b1_12.03.2009.doc. Accessed 31 Mar 2009
Acknowledgements
We acknowledge the financial support provided by the Bundesärztekammer. We also thank Ms. Marion Peters for her assistance in the study.
Conflict of interest
The authors indicate no financial relationship with the organisation that sponsored the research. The authors declare that they have no conflict of interest.
Data were presented at the 18th Conference for Tumour Documentation of Clinical and Epidemiological Cancer Registries, held in Jena, Germany, on April 1–3, 2009.
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Merkel, S., Klossek, D., Göhl, J. et al. Quality management in rectal carcinoma: what is feasible?. Int J Colorectal Dis 24, 931–942 (2009). https://doi.org/10.1007/s00384-009-0736-9
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DOI: https://doi.org/10.1007/s00384-009-0736-9