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Laparoscopic or open surgery for the cancer of the middle and lower rectum short-term outcomes of a comparative non-randomised study

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Abstract

Introduction

The study compares the short-term results of the laparoscopic and open approach for the surgical treatment of rectal cancer. Consecutive cases with rectal cancer operated upon with laparoscopy from 2004 to 2007 were compared to open rectal cancer cases. Total mesorectal excision (TME) was attempted in all cases.

Patients and methods

Forty-two cases were included in the OPEN and 45 in the LAP group and were matched for age, gender, disease stage and operation type.

Surgical procedure

Duration of surgery was longer and blood transfusion requirements were less in the LAP group. Higher blood loss was observed in patients with neoadjuvant treatment in both groups. Patients with neoadjuvant treatment in the OPEN group had higher operation time, but that was not the case in the LAP group. There were three conversions (7%).

Results

Overall morbidity was higher in the OPEN group. LAP group patients were found to recover faster. R0 resection was achieved in 88% in the OPEN and 94% in the LAP group.

Discussion

Less morbidity and faster recovery is offered after laparoscopic TME. Quality of surgery assessed by histopathology is similar between the approaches. Neoadjuvant chemoradiation seems to have significant impact on blood loss but results in longer operation times of the OPEN group.

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References

  1. Lacy AM, Garcia-Valdecasas JC, Delgado S et al (2002) Laparoscopic-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomized trial. Lancet 359:2224–2229

    Article  PubMed  Google Scholar 

  2. Leung KL, Kwok SPY, Lam SCW et al (2004) Laparoscopic resection of rectosigmoid carcinoma: prospective randomised trial. Lancet 363:1187–1192

    Article  PubMed  Google Scholar 

  3. The COST Group (2004) A comparison of laparoscopically-assisted and open colectomy for colon cancer. N Engl J Med 350:2050–2059

    Article  Google Scholar 

  4. Guillou PJ, Quirke P, Thorpe E et al (2005) Short-term end-points of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC-CLASICC trial): multicentre, randomised controlled trial. Lancet 365:1718–1726

    Article  PubMed  Google Scholar 

  5. Veldkamp R, Kuhry E, Hop WC et al (2005) CoLon cancer laparoscopic or open resection study group (COLOR) Lancet Oncol 6(7):477–484

    Article  PubMed  Google Scholar 

  6. Bonjer HJ, Hop WC, Nelson H et al (2007) Laparoscopically assisted versus open colectomy for colon cancer: a meta-analysis. Arch Surg 142:289–303

    Article  Google Scholar 

  7. Jayne DG, Guillou PJ, Thorpe E et al (2007) Randomised trial of laparoscopic-assisted resection of colorectal carcinoma: 3-year results of the UK MRC CLASICC trial group. J Clin Oncol 25:3061–3308

    Article  PubMed  Google Scholar 

  8. Aziz O, Constandinides V, Tekkis PP et al (2006) Laparoscopic versus open surgery for rectal cancer: a meta-analysis. Ann Surg Oncol 13(3):413–424

    Article  PubMed  Google Scholar 

  9. Araujo SE, da Silva de Sousa AH Jr, de Campos FG et al (2003) Conventional approach versus abdominoperineal resection for rectal cancer treatment after neoadjuvant chemoradiation: results of a prospective randomized trial. Rev Hosp Clin Fac Med Sao Paolo 58:133–140

    Google Scholar 

  10. Quah HM, Jayne DG, Eu KW, Seow-Choen F (2002) Bladder and sexual dysfunction following laparoscopically assisted and conventional open mesorectal resection for cancer. Br J Surg 89:1551–1556

    Article  PubMed  CAS  Google Scholar 

  11. Pechlivanides G, Gouvas N, Tsiaoussis J et al (2007) Lymph node clearance after total mesorectal excision for rectal cancer: laparoscopic versus open approach. Dig Dis 25:94–99

    Article  PubMed  Google Scholar 

  12. Zhou ZG, Hu M, Li Y et al (2004) Laparoscopic versus open total mesorectal excision with anal sphincter preservation for low rectal cancer. Surg Endosc 18:1211–1215

    Article  PubMed  Google Scholar 

  13. Nagtegaal ID, Marijen CAM, Kranenbarg K, van de Velde CJH, van Krieken JHJM (2002) Circumferential margin is still an important predictor of local recurrence in rectal carcinoma: not one mm but two mm is the limit. Am J Surg Pathol 26:350–357

    Article  PubMed  Google Scholar 

  14. Quirke P, Durdey R, Dixon MF, Williams NS (1986) Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision. Lancet 2(8514):996–999

    Article  PubMed  CAS  Google Scholar 

  15. Heald RJ, Husband EM, Ryall RDH (1982) The mesorectum in rectal cancer surgery-the clue to pelvic recurrence. Br J Surg 69:613–616

    Article  PubMed  CAS  Google Scholar 

  16. Heald RJ, Moran BJ, Brown G, Daniels IR (2004) Optimal total mesorectal excision for rectal cancer is by dissection in front of Denonvilliers’ fascia. Br J Surg 91:121–123

    Article  PubMed  CAS  Google Scholar 

  17. Feliciotti F, Guerrieri M, Paganini AM et al (2003) Long-term results of laparoscopic versus open resections of rectal cancer for 124 unselected patients. Surg Endosc 17:7–13

    Article  Google Scholar 

  18. Morino M, PArinin U, Giraudo G et al (2003) Laparoscopic total mesorectal excision. A consecutive series of 100 patients. Ann Surg 237:335–342

    Article  PubMed  Google Scholar 

  19. Leroy J, Jamali F, Forbes L et al (2004) Laparoscopic total mesorectal excision (TME) for rectal cancer. Surg Endosc 18:281–289

    Article  PubMed  CAS  Google Scholar 

  20. Law WL, Choi HK, Seto CL et al (2006) Laparoscopic and open anterior resection for upper and mid rectal cancer: an evaluation of outcomes. Dis Colon Rectum 49:1–8

    Article  Google Scholar 

  21. Pugliese R, Di Lernia S, Sansonna F et al (2008) Results of anterior resection for rectal adenocarcinoma: retrospective analysis of 157 cases. Am J Surg 195:233–238

    Article  PubMed  Google Scholar 

  22. Marijnen CA, Kpiteijn E, van de Velde CJ et al (2002) Acute side effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer: report of a multicenter randomized trial. J Clin Oncol 20:817–825

    Article  PubMed  CAS  Google Scholar 

  23. Jansson-Frykholm G, Glimelius B (2001) Combined chemo-radiotherapy vs radiotherapy in the treatment of primary non-resectable adenocarcinoma of the rectum. Int J Rad Oncol Biol Phys 50:427–434

    Article  Google Scholar 

  24. Colorectal Cancer Collaborative Group (2001) Adjuvant radiotherapy for rectal cancer a systemic overview of 8507 patients from 22 randomised trials. Lancet 358:1291–1304

    Article  Google Scholar 

  25. Sauer R, Becker H, Hohenberger W et al (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351:1731–1740

    Article  PubMed  CAS  Google Scholar 

  26. Bujko K, Nowacki MP, Nasierowska A et al (2004) Sphincter preservation following preoperative radiotherapy for rectal cancer: report of a randomized trial comparing short-term vs fractionated radiochemotherapy. Radiother Oncol 72:15–24

    Article  PubMed  CAS  Google Scholar 

  27. Bosset JF, Calais G, Mineur L et al (2005) Enhanced tumouricidal effect of chemotherapy with preoperative radiotherapy for rectal cancer. Preliminary results of EORTC 22921. J Clin Oncol 23:5620–5627

    Article  PubMed  CAS  Google Scholar 

  28. Folkesson J, Birgisson H, Palhman L et al (2005) Swedish Rectal Cancer Trial: long lasting benefits from radiotherapyon survival and local recurrence rate. Clin Oncol 23:5644–5650

    Article  Google Scholar 

  29. Pucciarelli S, Toppan P, Friso ML et al (2004) Complete pathologic response following preoperative chemoradiation therapy for middle to lower rectal cancer is not a prognostic factor for better outcome. Dis Colon Rectum 47:798–807

    Article  Google Scholar 

  30. Heis MM, Tarabichi A, Delanoff C et al (1996) Perisurgical erythropoietin application in anemic patients with colorectal cancer: A double-blind randomized study. Surgery 119:523–527

    Article  Google Scholar 

  31. Bretagnol F, Rullier Couderc P et al (2003) Technical and oncological feasibility of laparoscopic total mesorectal excision with pouch colorectal anastomosis for rectal cancer. Colorectal Dis 5:451–453

    Article  PubMed  CAS  Google Scholar 

  32. Lelong B, Bege T, Esterni B et al (2006) Short-term outcomes after laparoscopic or open restorative mesorectal excision for rectal cancer: a comparative cohort study. Dis Colon Rectum 50:176–183

    Article  Google Scholar 

  33. Tekkis PP, Senagore AJ, Delaney CP (2005) Conversion rates in laparoscopic colorectal surgery: a predictive model with 1253 patients. Surg Endosc 19:47–54

    Article  PubMed  CAS  Google Scholar 

  34. Hartley JE, Mehigan BJ, Qureshi AE et al (2001) Total mesorectal excision: assessment of the laparoscopic approach. Dis Colon Rectum 44:315–321

    Article  PubMed  CAS  Google Scholar 

  35. Scheidbach H, Rose J, Huegel O et al (2004) Results of the laparoscopic treatment of rectal cancer: analysis of 520 cases. Tech Coloproctol 8(Suppl 1):22–24

    Article  Google Scholar 

  36. Laurent C, Leblanc F, Gineste C, Saric J, Rullier E (2007) Laparoscopic approach in surgical treatment of rectal cancer. Br J Surg 94:1555–1561

    Article  PubMed  CAS  Google Scholar 

  37. Wu FP, Sietses C, von Blomberg BM, van Leeuween PA, Meijer S, Cuesta MA (2003) Systemic and peritoneal inflammatory response after laparoscopic or conventional colon resection in cancer patients: a prospective, randomized trial. Dis Colon Rectum 46:147–155

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Evaghelos Xynos.

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Gouvas, N., Tsiaoussis, J., Pechlivanides, G. et al. Laparoscopic or open surgery for the cancer of the middle and lower rectum short-term outcomes of a comparative non-randomised study. Int J Colorectal Dis 24, 761–769 (2009). https://doi.org/10.1007/s00384-009-0671-9

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  • DOI: https://doi.org/10.1007/s00384-009-0671-9

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