Abstract
Purpose
The use of mechanical bowel preparation (MBP) before pediatric colorectal surgery remains the standard of care for many pediatric surgeons, though the value of MBP remains unclear. The aim of this study was to systematically review and analyze the effect of MBP on the incidence of postoperative complications; anastomotic leakage, intra-abdominal infection, and wound infection, following colorectal surgery in pediatric patients.
Methods
Embase, MEDLINE, Web of Science, and CINAHL databases were searched to compare the effect of MBP versus no MBP prior to elective pediatric colorectal surgery on postoperative complications. After critical appraisal of included studies, meta-analyses were conducted using a random-effect model.
Results
1731 papers were retrieved; 2 randomized controlled trials and 4 retrospective cohort studies met the inclusion criteria. The overall quality of evidence was low. MBP before colorectal surgery did not significantly decrease the occurrence of anastomotic leakage, intra-abdominal infection, or wound infection compared to no MBP.
Conclusions
On the basis of the existing evidence, the use of MBP before colorectal surgery in children seems not to decrease the incidence of postoperative complications compared to no MBP. To overcome confounding factors such as antibiotic prophylaxis, age and type of operation, a multicentre prospective study is suggested to validate these results.
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References
Nichols RL, Condon RE (1971) Preoperative preparation of the colon. Surg Gynecol Obstet 132:323–337
Nichols RL, Broido P, Condon RE et al (1973) Effect of preoperative neomycin-erythromycin intestinal preparation on the incidence of infectious complications following colon surgery. Ann Surg 178:453–462. https://doi.org/10.1097/00000658-197310000-00008
Nelson RL, Gladman E, Barbateskovic M (2014) Antimicrobial prophylaxis for colorectal surgery. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD001181.pub4
Bellows CF, Mills KT, Kelly TN, Gagliardi G (2011) Combination of oral non-absorbable and intravenous antibiotics versus intravenous antibiotics alone in the prevention of surgical site infections after colorectal surgery: a meta-analysis of randomized controlled trials. Tech Coloproctol 15:385–395. https://doi.org/10.1007/s10151-011-0714-4
Cannon JA, Altom LK, Deierhoi RJ et al (2012) Preoperative oral antibiotics reduce surgical site infection following elective colorectal resections. Dis Colon Rectum 55:1160–1166. https://doi.org/10.1097/DCR.0b013e3182684fac
Kim EK, Sheetz KH, Bonn J et al (2014) A statewide colectomy experience the role of full bowel preparation in preventing surgical site infection. Ann Surg 259:310–314. https://doi.org/10.1097/SLA.0b013e3182a62643
Toneva GD, Deierhoi RJ, Morris M et al (2013) Oral antibiotic bowel preparation reduces length of stay and readmissions after colorectal surgery. J Am Coll Surg 216:762–763. https://doi.org/10.1016/j.jamcollsurg.2012.12.039
Rollins KE, Javanmard-Emamghissi H, Lobo DN (2018) Impact of mechanical bowel preparation in elective colorectal surgery: a meta-analysis. World J Gastroenterol 24:519–536. https://doi.org/10.3748/wjg.v24.i4.519
Fry DE (2011) Colon preparation and surgical site infection. Am J Surg 202:225–232. https://doi.org/10.1016/j.amjsurg.2010.08.038
Contant CME, Hop WCJ, van’t Sant HP et al (2007) Mechanical bowel preparation for elective colorectal surgery: a multicentre randomised trial. Lancet 370:2112–2117. https://doi.org/10.1016/S0140-6736%2807%2961905-9
Breckler FD, Fuchs JR, Rescorla FJ (2007) Survey of pediatric surgeons on current practices of bowel preparation for elective colorectal surgery in children. Am J Surg 193:315–318. https://doi.org/10.1016/j.amjsurg.2006.09.026
Feng C, Sidhwa F, Anandalwar S et al (2015) Contemporary practice among pediatric surgeons in the use of bowel preparation for elective colorectal surgery: a survey of the American Pediatric Surgical Association. J Pediatr Surg 50:1636–1640. https://doi.org/10.1016/j.jpedsurg.2015.04.005
Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Academia and clinic annals of internal medicine preferred reporting items for systematic reviews and meta-analyses. Ann Intern Med 151:264–269. https://doi.org/10.7326/0003-4819-151-4-200908180-00135
Higgins J, Green S (2011) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). In: Cochrane Collab. http://www.handbook.cochrane.org. Accessed 1 Jan 2018
Higgins JPT, Sterne JAC, Savović J, Page MJ, Hróbjartsson A, Boutron I, Reeves BES (2016) A revised tool for assessing risk of bias in randomized trials In: Chandler J, McKenzie J, Boutron I, Welch V (eds) Cochrane Methods. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD201601
Sterne JA, Hernán MA, Reeves BC et al (2016) ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ 355:4–10. https://doi.org/10.1136/bmj.i4919
Guyatt GH, Oxman AD, Schünemann HJ et al (2011) GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology. J Clin Epidemiol 64:380–382. https://doi.org/10.1016/j.jclinepi.2010.09.011
Guyatt G, Oxman AD, Akl EA et al (2011) GRADE guidelines: 1. Introduction—GRADE evidence profiles and summary of findings tables. J Clin Epidemiol 64:383–394. https://doi.org/10.1016/j.jclinepi.2010.04.026
Guyatt GH, Oxman AD, Kunz R et al (2011) GRADE guidelines: 2. Framing the question and deciding on important outcomes. J Clin Epidemiol 64:395–400. https://doi.org/10.1016/j.jclinepi.2010.09.012
Balshem H, Helfand M, Schünemann HJ et al (2011) GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol 64:401–406. https://doi.org/10.1016/j.jclinepi.2010.07.015
Guyatt GH, Oxman AD, Vist G et al (2011) GRADE guidelines: 4. Rating the quality of evidence—study limitations (risk of bias). J Clin Epidemiol 64:407–415. https://doi.org/10.1016/j.jclinepi.2010.07.017
Guyatt GH, Oxman AD, Montori V et al (2011) GRADE guidelines: 5. Rating the quality of evidence—publication bias. J Clin Epidemiol 64:1277–1282. https://doi.org/10.1016/j.jclinepi.2011.01.011
Guyatt GH, Oxman AD, Kunz R et al (2011) GRADE guidelines 6. Rating the quality of evidence—imprecision. J Clin Epidemiol 64:1283–1293. https://doi.org/10.1016/j.jclinepi.2011.01.012
Guyatt GH, Oxman AD, Kunz R et al (2011) GRADE guidelines: 7. Rating the quality of evidence—inconsistency. J Clin Epidemiol 64:1294–1302. https://doi.org/10.1016/j.jclinepi.2011.03.017
Guyatt GH, Oxman AD, Kunz R et al (2011) GRADE guidelines: 8. Rating the quality of evidence—indirectness. J Clin Epidemiol 64:1303–1310. https://doi.org/10.1016/j.jclinepi.2011.04.014
Guyatt GH, Oxman AD, Sultan S et al (2011) GRADE guidelines: 9. Rating up the quality of evidence. J Clin Epidemiol 64:1311–1316. https://doi.org/10.1016/j.jclinepi.2011.06.004
Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 719–748
Aldrink JH, McManaway C, Wang W, Nwomeh BC (2015) Mechanical bowel preparation for children undergoing elective colorectal surgery. J Pediatr Gastroenterol Nutr 60:503–507. https://doi.org/10.1097/MPG.0000000000000651
Shah M, Ellis CT, Philips MR et al (2016) Preoperative bowel preparation prior to elective bowel resection or ostomy closure in the pediatric patient population has no impact on outcomes. A prospective randomized study. Am Surg 82:801–806. https://doi.org/10.1158/1940-6207.CAPR-14-0359.Nrf2-dependent
Leys CM, Austin MT, Pietsch JB et al (2005) Elective intestinal operations in infants and children without mechanical bowel preparation: a pilot study. J Pediatr Surg 40:978–982. https://doi.org/10.1016/j.jpedsurg.2005.03.013
Breckler FD, Rescorla FJ, Billmire DF (2010) Wound infection after colostomy closure for imperforate anus in children: utility of preoperative oral antibiotics. J Pediatr Surg 45:1509–1513. https://doi.org/10.1016/j.jpedsurg.2009.10.054
Serrurier K, Liu J, Breckler F et al (2012) A multicenter evaluation of the role of mechanical bowel preparation in pediatric colostomy takedown. J Pediatr Surg 47:190–193. https://doi.org/10.1016/j.jpedsurg.2011.10.044
Ares GJ, Helenowski I, Hunter CJ et al (2017) Effect of preadmission bowel preparation on outcomes of elective colorectal procedures in young children. J Pediatr Surg. https://doi.org/10.1016/j.jpedsurg.2017.03.060
Frizelle F, Colls B (2005) Hyponatremia and seizures after bowel preparation: report of three cases. Dis Colon Rectum 48:393–396. https://doi.org/10.1007/s10350-004-0778-6
Sinha SK, Kanojia RP, Rawat JD et al (2007) Comparison of three solutions for total gut irrigation in pediatric patients. Pediatr Surg Int 23:581–584. https://doi.org/10.1007/s00383-007-1919-5
Keighley MR, Condon RE (1982) A clinical and physiological evaluation of bowel preparation for elective colorectal surgery. World J Surg 6:464–470. https://doi.org/10.1007/BF01657683
Gordon M, Karlsen F, Isaji S, Teck G-O (2017) Bowel preparation for elective procedures in children: a systematic review and meta-analysis. BMJ Paediatr Open. https://doi.org/10.1136/bmjpo-2017-000118
Goligher JC (1984) Surgery of the anus, rectum and colon, 5th edn. Bailliere Tindall Ltd, London
Mahajna A, Krausz M, Rosin D et al (2005) Bowel preparation is associated with spillage of bowel contents in colorectal surgery. Dis Colon Rectum 48:1626–1631. https://doi.org/10.1007/s10350-005-0073-1
Saha AK, Chowdhury F, Jha AK et al (2014) Mechanical bowel preparation versus no preparation before colorectal surgery: a randomized prospective trial in a tertiary care institute. J Nat Sci Biol Med 5:421–424. https://doi.org/10.4103/0976-9668.136214
de Lissovoy G, Fraeman K, Hutchins V et al (2009) Surgical site infection: Incidence and impact on hospital utilization and treatment costs. Am J Infect Control 37:387–397. https://doi.org/10.1016/j.ajic.2008.12.010
Donahue M, Evangelista J, Shamberger R (1994) Effect of Golytely on serum electrolytes and hydration status of infants. J Pediatr Surg 29:1095–1096. https://doi.org/10.1016/0022-3468%2894%2990286-0
Morris MS, Graham LA, Heslin MJ et al (2014) Oral antibiotic bowel prep significantly reduces surgical site infection rates and readmission rates in elective colorectal surgery. J Am Coll Surg 219:S18–S19. https://doi.org/10.1016/j.jamcollsurg.2014.07.032
Scarborough JE, Mantyh CR, Sun Z et al (2015) Combined mechanical and oral antibiotic bowel preparation reduces incisional surgical site infection and anastomotic leak rates after elective colorectal resection an analysis of colectomy-targeted ACS NSQIP. Ann Surg 262:331–337. https://doi.org/10.1097/SLA.0000000000001041
Kiran RP, Murray ACA, Chiuzan C et al (2015) Combined preoperative mechanical bowel preparation with oral antibiotics significantly reduces surgical site infection, anastomotic leak, and ileus after colorectal surgery. Ann Surg 262:416–423. https://doi.org/10.1097/SLA.0000000000001416
Garfinkle R, Abou-Khalil J, Morin N et al (2017) Is there a role for oral antibiotic preparation alone before colorectal surgery? ACS-NSQIP analysis by coarsened exact matching. Dis Colon Rectum 60:729–737. https://doi.org/10.1097/DCR.0000000000000851
Debo Adeyemi S, Tai da Rocha-Afodu J (1986) Clinical studies of 4 methods of bowel preparation in colorectal surgery. Eur Surg Res 18:331–336
Vila JJ, Gutierrez C, Garcia-Sala C, Ruiz S (1987) Whole bowel irrigation: experience in pediatric patients. J Pediatr Surg 22:447–450. https://doi.org/10.1016/S0022-3468%2887%2980267-1
Chattopadhyay A, Prakash B, Vepakomma D et al (2004) A prospective comparison of two regimes of bowel preparation for pediatric colorectal procedures: Normal saline with added potassium vs. polyethylene glycol. Pediatr Surg Int 20:127–129. https://doi.org/10.1007/s00383-003-1104-4
Ameh EA, Lukong CS, Mshelbwala PM et al (2011) One-day bowel preparation in children with colostomy using normal saline. Afr J Paediatr Surg 8:291–293. https://doi.org/10.4103/0189-6725.91670
Askarpour S, Peyvasteh M, Dastyar AA, Javaherizadeh H (2013) Bowel preparation for colorectal surgery: with and without mannitol. Prz Gastroenterol 8:305–307. https://doi.org/10.5114/pg.2013.38733
Kumar A, Hussain A (2013) Preoperative bowel preparation in children: polyethylene glycol versus normal saline. Afr J Paediatr Surg 10:235–238. https://doi.org/10.4103/0189-6725.120889
Pennington EC, Feng C, St Peter SD et al (2014) Use of mechanical bowel preparation and oral antibiotics for elective colorectal procedures in children: is current practice evidence-based? J Pediatr Surg 49:1030–1035. https://doi.org/10.1016/j.jpedsurg.2014.01.048
Lee JM, Tam PK, Saing H (1986) Whole-gut irrigation in infants and young children. Dis Colon Rectum 29:252–254
Acknowledgements
Dr. Agostino Pierro was supported by the endowment of the Robert M. Filler Chair of Surgery and The Hospital for Sick Children.
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Robert M. Filler Chair of Surgery, the Hospital for Sick Children. The authors have no financial relationships relevant to disclose.
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Janssen Lok, M., Miyake, H., O’Connell, J.S. et al. The value of mechanical bowel preparation prior to pediatric colorectal surgery: a systematic review and meta-analysis. Pediatr Surg Int 34, 1305–1320 (2018). https://doi.org/10.1007/s00383-018-4345-y
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DOI: https://doi.org/10.1007/s00383-018-4345-y