Skip to main content
SpringerLink
Log in

Analysis of 2141 pediatric craniopharyngioma admissions in the USA utilizing the Kids’ Inpatient Database (KID): predictors of discharge disposition

  • Original Article
  • Published:
Child's Nervous System Aims and scope Submit manuscript

Abstract

Objectives

To recognize the national trends in management of pediatric craniopharyngioma and to address the significant predictors of discharge disposition.

Methods

We utilized the Kids’ Inpatient Database (KID), a pediatric inpatient sample generated by the Healthcare Cost and Utilization Project (HCUP) triennially from 1997 to 2016.

Results

KID contains 2141 pediatric craniopharyngioma admissions. Patient demographics had no effect on discharge disposition. Based on the multivariable logistic regression analysis, we confirmed a significantly higher non-routine discharge rate among patients with hydrocephalus (P = 0.01). Patients who developed diabetes insipidus were at higher risk for non-routine discharge (P = 0.02). Admission of patients to a freestanding children’s hospital increased the likelihood of routine discharge (P = 0.001).

Conclusion

Hydrocephalus, diabetes insipidus, and admission to a freestanding children’s hospital are significant independent predictors of discharge disposition.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Ali ZS, Lang SS, Kamat AR, Adappa ND, Palmer JN, Storm PB, Lee JY (2013) Suprasellar pediatric craniopharyngioma resection via endonasal endoscopic approach. Child’s Nerv Syst 29:2065–2070. https://doi.org/10.1007/s00381-013-2153-1

    Article  Google Scholar 

  2. Bakhsheshian J, Jin DL, Chang KE, Strickland BA, Donoho DA, Cen S, Mack WJ, Attenello F, Christian EA, Zada G (2016) Risk factors associated with the surgical management of craniopharyngiomas in pediatric patients: analysis of 1961 patients from a national registry database. Neurosurg Focus 41:E8. https://doi.org/10.3171/2016.8.Focus16268

    Article  PubMed  PubMed Central  Google Scholar 

  3. Barreca T, Perria C, Francaviglia N, Rolandi E (1984) Evaluation of anterior pituitary function in adult patients with craniopharyngiomas. Acta Neurochir 71:263–272

    Article  CAS  PubMed  Google Scholar 

  4. Bunin GR, Surawicz TS, Witman PA, Preston-Martin S, Davis F, Bruner JM (1998) The descriptive epidemiology of craniopharyngioma. J Neurosurg 89:547–551. https://doi.org/10.3171/jns.1998.89.4.0547

    Article  CAS  PubMed  Google Scholar 

  5. Burns EM, Rigby E, Mamidanna R, Bottle A, Aylin P, Ziprin P, Faiz OD (2012) Systematic review of discharge coding accuracy. Journal of public health (Oxford, England) 34:138–148. https://doi.org/10.1093/pubmed/fdr054

    Article  CAS  Google Scholar 

  6. Caldarelli M, Massimi L, Tamburrini G, Cappa M, Di Rocco C (2005) Long-term results of the surgical treatment of craniopharyngioma: the experience at the Policlinico Gemelli, Catholic University, Rome. Child’s Nerv Syst 21:747–757. https://doi.org/10.1007/s00381-005-1186-5

    Article  CAS  Google Scholar 

  7. Clark AJ, Cage TA, Aranda D, Parsa AT, Sun PP, Auguste KI, Gupta N (2013) A systematic review of the results of surgery and radiotherapy on tumor control for pediatric craniopharyngioma. Child’s Nerv Syst 29:231–238. https://doi.org/10.1007/s00381-012-1926-2

    Article  Google Scholar 

  8. Cohen M, Guger S, Hamilton J (2011) Long term sequelae of pediatric craniopharyngioma - literature review and 20 years of experience. Front Endocrinol 2:81. https://doi.org/10.3389/fendo.2011.00081

    Article  Google Scholar 

  9. De Vile CJ, Grant DB, Kendall BE, Neville BG, Stanhope R, Watkins KE, Hayward RD (1996) Management of childhood craniopharyngioma: can the morbidity of radical surgery be predicted? J Neurosurg 85:73–81. https://doi.org/10.3171/jns.1996.85.1.0073

    Article  PubMed  Google Scholar 

  10. Elliott RE, Hsieh K, Hochm T, Belitskaya-Levy I, Wisoff J, Wisoff JH (2010) Efficacy and safety of radical resection of primary and recurrent craniopharyngiomas in 86 children. J Neurosurg Pediatr 5:30–48. https://doi.org/10.3171/2009.7.Peds09215

    Article  PubMed  Google Scholar 

  11. Gonc EN, Yordam N, Ozon A, Alikasifoglu A, Kandemir N (2004) Endocrinological outcome of different treatment options in children with craniopharyngioma: a retrospective analysis of 66 cases. Pediatr Neurosurg 40:112–119. https://doi.org/10.1159/000079852

    Article  PubMed  Google Scholar 

  12. Harrell FE Jr (2015) Regression modeling strategies: with applications to linear models, logistic and ordinal regression, and survival analysis. Springer, Berlin

    Book  Google Scholar 

  13. Hoffman HJ, De Silva M, Humphreys RP, Drake JM, Smith ML, Blaser SI (1992) Aggressive surgical management of craniopharyngiomas in children. J Neurosurg 76:47–52. https://doi.org/10.3171/jns.1992.76.1.0047

    Article  CAS  PubMed  Google Scholar 

  14. Jung TY, Jung S, Moon KS, Kim IY, Kang SS, Kim JH (2010) Endocrinological outcomes of pediatric craniopharyngiomas with anatomical pituitary stalk preservation: preliminary study. Pediatr Neurosurg 46:205–212. https://doi.org/10.1159/000318426

    Article  PubMed  Google Scholar 

  15. Karavitaki N, Brufani C, Warner JT, Adams CB, Richards P, Ansorge O, Shine B, Turner HE, Wass JA (2005) Craniopharyngiomas in children and adults: systematic analysis of 121 cases with long-term follow-up. Clin Endocrinol 62:397–409. https://doi.org/10.1111/j.1365-2265.2005.02231.x

    Article  CAS  Google Scholar 

  16. Lafferty AR, Chrousos GP (1999) Pituitary tumors in children and adolescents. J Clin Endocrinol Metab 84:4317–4323. https://doi.org/10.1210/jcem.84.12.6215

    Article  CAS  PubMed  Google Scholar 

  17. Merchant TE, Kiehna EN, Sanford RA, Mulhern RK, Thompson SJ, Wilson MW, Lustig RH, Kun LE (2002) Craniopharyngioma: the St. Jude Children’s Research Hospital experience 1984-2001. Int J Radiat Oncol Biol Phys 53:533–542

    Article  PubMed  Google Scholar 

  18. Muller HL (2010) Childhood craniopharyngioma--current concepts in diagnosis, therapy and follow-up. Nat Rev Endocrinol 6:609–618. https://doi.org/10.1038/nrendo.2010.168

    Article  PubMed  Google Scholar 

  19. Muller HL, Emser A, Faldum A, Bruhnken G, Etavard-Gorris N, Gebhardt U, Oeverink R, Kolb R, Sorensen N (2004) Longitudinal study on growth and body mass index before and after diagnosis of childhood craniopharyngioma. J Clin Endocrinol Metab 89:3298–3305. https://doi.org/10.1210/jc.2003-031751

    Article  CAS  PubMed  Google Scholar 

  20. Muller HL, Bruhnken G, Emser A, Faldum A, Etavard-Gorris N, Gebhardt U, Kolb R, Sorensen N (2005) Longitudinal study on quality of life in 102 survivors of childhood craniopharyngioma. Child’s Nerv Syst 21:975–980. https://doi.org/10.1007/s00381-004-1124-y

    Article  Google Scholar 

  21. Paja M, Lucas T, Garcia-Uria J, Salame F, Barcelo B, Estrada J (1995) Hypothalamic-pituitary dysfunction in patients with craniopharyngioma. Clin Endocrinol 42:467–473

    Article  CAS  Google Scholar 

  22. Poretti A, Grotzer MA, Ribi K, Schonle E, Boltshauser E (2004) Outcome of craniopharyngioma in children: long-term complications and quality of life. Dev Med Child Neurol 46:220–229

    Article  PubMed  Google Scholar 

  23. Prabhu VC, Brown HG (2005) The pathogenesis of craniopharyngiomas. Child’s Nerv Syst 21:622–627. https://doi.org/10.1007/s00381-005-1190-9

    Article  Google Scholar 

  24. Steno J, Bizik I, Steno A, Matejcik V (2011) Craniopharyngiomas in children: how radical should the surgeon be? Child’s Nerv Syst 27:41–54. https://doi.org/10.1007/s00381-010-1330-8

    Article  Google Scholar 

  25. Sughrue ME, Yang I, Kane AJ, Fang S, Clark AJ, Aranda D, Barani IJ, Parsa AT (2011) Endocrinologic, neurologic, and visual morbidity after treatment for craniopharyngioma. J Neuro-Oncol 101:463–476. https://doi.org/10.1007/s11060-010-0265-y

    Article  Google Scholar 

  26. Titsworth WL, Scott RM, Smith ER (2016) National analysis of 2454 pediatric moyamoya admissions and the effect of hospital volume on outcomes. Stroke 47:1303–1311. https://doi.org/10.1161/strokeaha.115.012168

    Article  PubMed  Google Scholar 

  27. Vittinghoff E, Glidden DV, Shiboski SC, McCulloch CE (2011) Regression methods in biostatistics: linear, logistic, survival, and repeated measures models. Springer Science & Business Media,

  28. Zada G, Laws ER (2010) Surgical management of craniopharyngiomas in the pediatric population. Hormone Res Paedia 74:62–66. https://doi.org/10.1159/000309349

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Boston Children’s Hospital – Harvard Medical School, 300 Longwood Ave, Boston, MA, 02115, USA

    Mohammed A. Fouda, Coleman P. Riordan & Liliana C. Goumnerova

  2. Dana Farber/Boston Children’s Cancer and Blood Disorders Center, Boston, MA, USA

    Mohammed A. Fouda & Liliana C. Goumnerova

  3. Division of Biostatistics, Department of Anesthesiology, Boston Children’s Hospital, Boston, MA, USA

    David Zurakowski & Liliana C. Goumnerova

Authors
  1. Mohammed A. Fouda
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Coleman P. Riordan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. David Zurakowski
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Liliana C. Goumnerova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mohammed A. Fouda.

Ethics declarations

Conflict of interest

The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fouda, M.A., Riordan, C.P., Zurakowski, D. et al. Analysis of 2141 pediatric craniopharyngioma admissions in the USA utilizing the Kids’ Inpatient Database (KID): predictors of discharge disposition. Childs Nerv Syst 36, 3007–3012 (2020). https://doi.org/10.1007/s00381-020-04640-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00381-020-04640-4

Keywords

Search

Navigation