Skip to main content

Advertisement

SpringerLink
Log in

A systematic review of the results of surgery and radiotherapy on tumor control for pediatric craniopharyngioma

  • Original Paper
  • Published:
Child's Nervous System Aims and scope Submit manuscript

Abstract

Objective

Craniopharyngiomas are rare tumors with bimodal incidence in the pediatric and adult age groups. Treatment strategies range from aggressive resection to planned limited resection combined with adjuvant therapies. Currently there is no consensus for standard of care for pediatric craniopharyngioma.

Materials and methods

We performed a systematic review of the published literature on pediatric craniopharyngioma. Patients were grouped based on extent of resection into gross total resection (GTR), subtotal resection (STR), and biopsy procedures. These groups were compared with respect to tumor control. Chi square was used to compare rates of recurrence. Kaplan–Meier was used to generate progression-free survival (PFS) estimates. Cox proportional hazard modeling was used to evaluate risk of progression. Each extent of resection group was also subdivided based on adjuvant therapy and compared.

Results

A total of 109 studies described extent of resection resulting in a cohort of 531 patients. Recurrence data were available for 377 patients. There was no difference in 1- or 5-year PFS between the groups who underwent GTR and STR combined with radiation (XRT; log-rank; p = 0.76; 1-year PFS 89 vs 84 %; 5-year PFS 77 vs 73 %, respectively). One-year PFS was 84 % for STR+XRT compared to 76 % for STR alone while 5-year PFS was 73 % for STR+XRT compared to 43 % for STR alone (log-rank; p = 0.003).

Conclusion

Although there are limitations of a systematic review of retrospective data, our results suggest that STR+XRT of pediatric craniopharyngioma is associated with similar rates of tumor control as GTR.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Abe T, Ludecke DK (1999) Transnasal surgery for infradiaphragmatic craniopharyngiomas in pediatric patients. Neurosurgery 44:957–964, discussion 964–956

    Article  PubMed  CAS  Google Scholar 

  2. Agozzino L, Ferraraccio F, Accardo M, Esposito S, Agozzino M, Cuccurullo L (2006) Morphological and ultrastructural findings of prognostic impact in craniopharyngiomas. Ultrastruct Pathol 30:143–150

    Article  PubMed  Google Scholar 

  3. Al-Mefty O, Ayoubi S, Kadri PA (2007) The petrosal approach for the total removal of giant retrochiasmatic craniopharyngiomas in children. J Neurosurg 106:87–92

    PubMed  Google Scholar 

  4. Amendola BE, Gebarski SS, Bermudez AG (1985) Analysis of treatment results in craniopharyngioma. J Clin Oncol 3:252–258

    PubMed  CAS  Google Scholar 

  5. Amendola BE, Wolf A, Coy SR, Amendola MA (2003) Role of radiosurgery in craniopharyngiomas: a preliminary report. Med Pediatr Oncol 41:123–127

    Article  PubMed  Google Scholar 

  6. Ammirati M, Samii M, Sephernia A (1990) Surgery of large retrochiasmatic craniopharyngiomas in children. Childs Nerv Syst 6:13–17

    Article  PubMed  CAS  Google Scholar 

  7. Aquilina K, Merchant TE, Rodriguez-Galindo C, Ellison DW, Sanford RA, Boop FA (2010) Malignant transformation of irradiated craniopharyngioma in children: report of 2 cases. J Neurosurg Pediatr 5:155–161

    Article  PubMed  Google Scholar 

  8. Bahuleyan B, Menon G, Nair S (2009) Immediate postoperative death due to hypothalamic injury following surgery for craniopharyngioma. J Clin Neurosci 16:850–851

    Article  PubMed  Google Scholar 

  9. Bartels U, Laperriere N, Bouffet E, Drake J (2012) Intracystic therapies for cystic craniopharyngioma in childhood. Front Endocrinol (Lausanne) 3:39

    Google Scholar 

  10. Behari S, Banerji D, Mishra A, Sharma S, Chhabra DK, Jain VK (2003) Intrinsic third ventricular craniopharyngiomas: report on six cases and a review of the literature. Surg Neurol 60:245–252, discussion 252–243

    Article  PubMed  Google Scholar 

  11. Belen D, Er U, Yigitkanli K, Bolay H (2007) Delayed neurotoxic complication of intracavitary bleomycin therapy for craniopharyngioma in a child who had previously undergone radiosurgery. Case report. J Neurosurg 106:391–393

    Article  PubMed  Google Scholar 

  12. Bhagwati SN, Deopujari CE, Parulekar GD (1990) Lamina terminalis approach for retrochiasmal craniopharyngiomas. Childs Nerv Syst 6:425–429

    Article  PubMed  CAS  Google Scholar 

  13. Blackburn TP, Doughty D, Plowman PN (1999) Stereotactic intracavitary therapy of recurrent cystic craniopharyngioma by instillation of 90yttrium. Br J Neurosurg 13:359–365

    Article  PubMed  CAS  Google Scholar 

  14. Boch AL, van Effenterre R, Kujas M (1997) Craniopharyngiomas in two consanguineous siblings: case report. Neurosurgery 41:1185–1187

    Article  PubMed  CAS  Google Scholar 

  15. Bohn D, Davids MR, Friedman O, Halperin ML (2005) Acute and fatal hyponatraemia after resection of a craniopharyngioma: a preventable tragedy. QJM 98:691–703

    Article  PubMed  CAS  Google Scholar 

  16. Buhl R, Nabavi A, Fritsch M, Mehdorn HM (2001) Nasopharyngeal extension of a craniopharyngioma in a 4 year old girl. Acta Neurochir (Wien) 143:1283–1285

    Article  CAS  Google Scholar 

  17. Bunin GR, Surawicz TS, Witman PA, Preston-Martin S, Davis F, Bruner JM (1998) The descriptive epidemiology of craniopharyngioma. J Neurosurg 89:547–551

    Article  PubMed  CAS  Google Scholar 

  18. Caceres A (2005) Intracavitary therapeutic options in the management of cystic craniopharyngioma. Childs Nerv Syst 21:705–718

    Article  PubMed  Google Scholar 

  19. Cavalheiro S, Dastoli PA, Silva NS, Toledo S, Lederman H, da Silva MC (2005) Use of interferon alpha in intratumoral chemotherapy for cystic craniopharyngioma. Childs Nerv Syst 21:719–724

    Article  PubMed  CAS  Google Scholar 

  20. Cavalheiro S, Di Rocco C, Valenzuela S, Dastoli PA, Tamburrini G, Massimi L, Nicacio JM, Faquini IV, Ierardi DF, Silva NS, Pettorini BL, Toledo SR (2010) Craniopharyngiomas: intratumoral chemotherapy with interferon-alpha: a multicenter preliminary study with 60 cases. Neurosurg Focus 28:E12

    Article  PubMed  Google Scholar 

  21. Cavallo LM, Prevedello DM, Solari D, Gardner PA, Esposito F, Snyderman CH, Carrau RL, Kassam AB, Cappabianca P (2009) Extended endoscopic endonasal transsphenoidal approach for residual or recurrent craniopharyngiomas. J Neurosurg 111:578–589

    Article  PubMed  Google Scholar 

  22. Chiou SM, Lunsford LD, Niranjan A, Kondziolka D, Flickinger JC (2001) Stereotactic radiosurgery of residual or recurrent craniopharyngioma, after surgery, with or without radiation therapy. Neuro Oncol 3:159–166

    PubMed  CAS  Google Scholar 

  23. Chung WY, Pan HC, Guo WY, Shiau CY, Wang LW, Wu HM, Lee LS (1998) Protection of visual pathway in gamma knife radiosurgery for craniopharyngiomas. Stereotact Funct Neurosurg 70(Suppl 1):139–151

    Article  PubMed  Google Scholar 

  24. Cinalli G, Spennato P, Cianciulli E, Fiorillo A, Di Maio S, Maggi G (2006) The role of transventricular neuroendoscopy in the management of craniopharyngiomas: three patient reports and review of the literature. J Pediatr Endocrinol Metab 19(Suppl 1):341–354

    PubMed  Google Scholar 

  25. Clayton PE, Price DA, Shalet SM, Gattemaneni HR (1988) Craniopharyngioma recurrence and growth hormone therapy. Lancet 1:642

    Article  PubMed  CAS  Google Scholar 

  26. Connolly ES Jr, Winfree CJ, Carmel PW (1997) Giant posterior fossa cystic craniopharyngiomas presenting with hearing loss. Report of three cases and review of the literature. Surg Neurol 47:291–299

    Article  PubMed  Google Scholar 

  27. Day JD, Giannotta SL, Fukushima T (1994) Extradural temporopolar approach to lesions of the upper basilar artery and infrachiasmatic region. J Neurosurg 81:230–235

    Article  PubMed  CAS  Google Scholar 

  28. Economos D (1979) Systemic shunting of residual intraparenchymatous cystic craniopharyngioma. Acta Neurochir Suppl (Wien) 28:363–366

    CAS  Google Scholar 

  29. Eldevik OP, Blaivas M, Gabrielsen TO, Hald JK, Chandler WF (1996) Craniopharyngioma: radiologic and histologic findings and recurrence. AJNR Am J Neuroradiol 17:1427–1439

    PubMed  CAS  Google Scholar 

  30. Elliott RE, Moshel YA, Wisoff JH (2009) Surgical treatment of ectopic recurrence of craniopharyngioma. Report of 4 cases. J Neurosurg Pediatr 4:105–112

    Article  PubMed  Google Scholar 

  31. Elliott RE, Hsieh K, Hochm T, Belitskaya-Levy I, Wisoff J, Wisoff JH (2010) Efficacy and safety of radical resection of primary and recurrent craniopharyngiomas in 86 children. J Neurosurg Pediatr 5:30–48

    Article  PubMed  Google Scholar 

  32. Fahlbusch R, Honegger J, Paulus W, Huk W, Buchfelder M (1999) Surgical treatment of craniopharyngiomas: experience with 168 patients. J Neurosurg 90:237–250

    Article  PubMed  CAS  Google Scholar 

  33. Feletti A, Marton E, Mazzucco GM, Fang S, Longatti P (2010) Amaurosis in infancy due to craniopharyngioma: a not-exceptional but often misdiagnosed symptom. Neurosurg Focus 28:E7

    Article  PubMed  Google Scholar 

  34. Filis AK, Moon K, Cohen AR (2009) Synchronous ventriculoscopic and microsurgical resection of complex craniopharyngiomas. Pediatr Neurosurg 45:434–436

    Article  PubMed  Google Scholar 

  35. Fraioli MF, Santoni R, Fraioli C, Contratti F (2006) “Conservative” surgical approach and early postoperative radiotherapy in a patient with a huge cystic craniopharyngioma. Childs Nerv Syst 22:151–155, discussion 158–163

    Article  PubMed  Google Scholar 

  36. Fraioli MF, Moschettoni L, Catena E, Fraioli C (2010) Cystic craniopharyngioma: trans-sphenoidal surgery and intra-cystic apposition of “bleomycin wax”. Acta Neurochir (Wien) 152:293–296

    Article  Google Scholar 

  37. Frangou EM, Tynan JR, Robinson CA, Ogieglo LM, Vitali AM (2009) Metastatic craniopharyngioma: case report and literature review. Childs Nerv Syst 25:1143–1147

    Article  PubMed  Google Scholar 

  38. Frank G, Pasquini E, Doglietto F, Mazzatenta D, Sciarretta V, Farneti G, Calbucci F (2006) The endoscopic extended transsphenoidal approach for craniopharyngiomas. Neurosurgery 59:ONS75-83, discussion ONS75-83

    Google Scholar 

  39. Frazier JL, Chaichana K, Jallo GI, Quinones-Hinojosa A (2008) Combined endoscopic and microscopic management of pediatric pituitary region tumors through one nostril: technical note with case illustrations. Childs Nerv Syst 24:1469–1478

    Article  PubMed  Google Scholar 

  40. Giller CA, Berger BD, Pistenmaa DA, Sklar F, Weprin B, Shapiro K, Winick N, Mulne AF, Delp JL, Gilio JP, Gall KP, Dicke KA, Swift D, Sacco D, Harris-Henderson K, Bowers D (2005) Robotically guided radiosurgery for children. Pediatr Blood Cancer 45:304–310

    Article  PubMed  Google Scholar 

  41. Gleeson H, Amin R, Maghnie M (2008) ‘Do no harm’: management of craniopharyngioma. Eur J Endocrinol 159(Suppl 1):S95–S99

    Article  PubMed  CAS  Google Scholar 

  42. Golshani KJ, Lalwani K, Delashaw JB, Selden NR (2009) Modified orbitozygomatic craniotomy for craniopharyngioma resection in children. J Neurosurg Pediatr 4:345–352

    Article  PubMed  Google Scholar 

  43. Gurkaynak M, Ozyar E, Zorlu F, Akyol FH, Atahan IL (1994) Results of radiotherapy in craniopharyngiomas analysed by the linear quadratic model. Acta Oncol 33:941–943

    Article  PubMed  CAS  Google Scholar 

  44. Hader WJ, Steinbok P, Hukin J, Fryer C (2000) Intratumoral therapy with bleomycin for cystic craniopharyngiomas in children. Pediatr Neurosurg 33:211–218

    Article  PubMed  CAS  Google Scholar 

  45. Hamamoto Y, Niino K, Adachi M, Hosoya T (2002) MR and CT findings of craniopharyngioma during and after radiation therapy. Neuroradiology 44:118–122

    Article  PubMed  CAS  Google Scholar 

  46. Hamlat A, Morandi X, Riffaud L, Carsin-Nicol B, Haegelen C, Helal H, Brassier G (2008) Transtemporal-transchoroidal approach and its transamygdala extension to the posterior chiasmatic cistern and diencephalo-mesencephalic lesions. Acta Neurochir (Wien) 150:317–327, discussion 327–318

    Article  CAS  Google Scholar 

  47. Hashizume C, Mori Y, Kobayashi T, Shibamoto Y, Nagai A, Hayashi N (2010) Stereotactic radiotherapy using Novalis for craniopharyngioma adjacent to optic pathways. J Neurooncol 98:239–247

    Article  PubMed  Google Scholar 

  48. Hofmann BM, Hollig A, Strauss C, Buslei R, Buchfelder M, Fahlbusch R (2012) Results after treatment of craniopharyngiomas: further experiences with 73 patients since 1997. J Neurosurg 116:373–384

    Article  PubMed  Google Scholar 

  49. Hoogenhout J, Otten BJ, Kazem I, Stoelinga GB, Walder AH (1984) Surgery and radiation therapy in the management of craniopharyngiomas. Int J Radiat Oncol Biol Phys 10:2293–2297

    Article  PubMed  CAS  Google Scholar 

  50. Hukin J, Visser J, Sargent M, Goddard K, Fryer C, Steinbok P (2005) Childhood craniopharyngioma: Vancouver experience. Childs Nerv Syst 21:758–765

    Article  PubMed  Google Scholar 

  51. Hukin J, Steinbok P, Lafay-Cousin L, Hendson G, Strother D, Mercier C, Samson Y, Howes W, Bouffet E (2007) Intracystic bleomycin therapy for craniopharyngioma in children: the Canadian experience. Cancer 109:2124–2131

    Article  PubMed  CAS  Google Scholar 

  52. Im SH, Wang KC, Kim SK, Chung YN, Kim HS, Lee CH, Cho BK (2003) Transsphenoidal microsurgery for pediatric craniopharyngioma: special considerations regarding indications and method. Pediatr Neurosurg 39:97–103

    Article  PubMed  Google Scholar 

  53. Inoue HK, Fujimaki H, Kohga H, Ono N, Hirato M, Ohye C (1997) Basal interhemispheric supra- and/or infrachiasmal approaches via superomedial orbitotomy for hypothalamic lesions: preservation of hypothalamo-pituitary functions in combination treatment with radiosurgery. Childs Nerv Syst 13:250–256

    Article  PubMed  CAS  Google Scholar 

  54. Israel ZH, Pomeranz S (1995) Intracranial craniopharyngioma seeding following radical resection. Pediatr Neurosurg 22:210–213

    Article  PubMed  CAS  Google Scholar 

  55. Jackson AS, St George EJ, Hayward RJ, Plowman PN (2003) Stereotactic radiosurgery. XVII: recurrent intrasellar craniopharyngioma. Br J Neurosurg 17:138–143

    Article  PubMed  CAS  Google Scholar 

  56. Jakacki RI, Cohen BH, Jamison C, Mathews VP, Arenson E, Longee DC, Hilden J, Cornelius A, Needle M, Heilman D, Boaz JC, Luerssen TG (2000) Phase II evaluation of interferon-alpha-2a for progressive or recurrent craniopharyngiomas. J Neurosurg 92:255–260

    Article  PubMed  CAS  Google Scholar 

  57. Jang WY, Lee KS, Son BC, Jeun SS, Hong YK, Lee SW, Yang SH (2009) Repeat operations in pediatric patients with recurrent craniopharyngiomas. Pediatr Neurosurg 45:451–455

    Article  PubMed  Google Scholar 

  58. Jeong IH, Lee JK, Moon KS, Joo SP, Kwak HJ, Kim TS, Kim JH, Kim SH (2006) Ectopic recurrence of craniopharyngioma: a case report and review of the literature. J Neurooncol 79:191–195

    Article  PubMed  Google Scholar 

  59. Jooma R, Kendall BE (1982) Intracranial tumours in the first year of life. Neuroradiology 23:267–274

    Article  PubMed  CAS  Google Scholar 

  60. Julow J, Lanyi F, Hajda M, Simkovics M, Arany I, Toth S, Pasztor E (1985) The radiotherapy of cystic craniopharyngioma with intracystic installation of 90Y silicate colloid. Acta Neurochir (Wien) 74:94–99

    Article  CAS  Google Scholar 

  61. Kawahara I, Tokunaga Y, Ishizaka S, Yagi N (2009) Reversible clinical and magnetic resonance imaging of central pontine myelinolysis following surgery for craniopharyngioma: serial magnetic resonance imaging studies. Neurol Med Chir (Tokyo) 49:120–123

    Article  Google Scholar 

  62. Keohane C, Hally M, Ryder DQ, Buckley TF (1994) Late recurrence of craniopharyngioma in the cerebellopontine angle in a fertile woman. J Neurol Neurosurg Psychiatry 57:873–874

    Article  PubMed  CAS  Google Scholar 

  63. Kiehna EN, Merchant TE (2010) Radiation therapy for pediatric craniopharyngioma. Neurosurg Focus 28:E10

    Article  PubMed  Google Scholar 

  64. Kim MS, Lee SI, Sim SH (1999) Brain tumors with cysts treated with Gamma Knife radiosurgery: is microsurgery indicated? Stereotact Funct Neurosurg 72(Suppl 1):38–44

    Article  PubMed  Google Scholar 

  65. Kim SD, Park JY, Park J, Lee JB, Kim SH, Lim DJ (2007) Radiological findings following postsurgical intratumoral bleomycin injection for cystic craniopharyngioma. Clin Neurol Neurosurg 109:236–241

    Article  PubMed  Google Scholar 

  66. Kitano M, Taneda M (2009) Extended transsphenoidal surgery for suprasellar craniopharyngiomas: infrachiasmatic radical resection combined with or without a suprachiasmatic trans-lamina terminalis approach. Surg Neurol 71:290–298, discussion 298

    Article  PubMed  Google Scholar 

  67. Klimo P Jr, Browd SR, Pravdenkova S, Couldwell WT, Walker ML, Al-Mefty O (2009) The posterior petrosal approach: technique and applications in pediatric neurosurgery. J Neurosurg Pediatr 4:353–362

    Article  PubMed  Google Scholar 

  68. Kobayashi T, Tanaka T, Kida Y (1994) Stereotactic gamma radiosurgery of craniopharyngiomas. Pediatr Neurosurg 21(Suppl 1):69–74

    Article  PubMed  Google Scholar 

  69. Kobayashi T, Kida Y, Mori Y, Hasegawa T (2005) Long-term results of gamma knife surgery for the treatment of craniopharyngioma in 98 consecutive cases. J Neurosurg 103:482–488

    PubMed  Google Scholar 

  70. Kodama T, Matsukado Y, Uemura S (1981) Intracapsular irradiation therapy of craniopharyngiomas with radioactive gold: indication and follow-up results. Neurol Med Chir (Tokyo) 21:49–58

    Article  CAS  Google Scholar 

  71. Kramer S, Southard M, Mansfield CM (1968) Radiotherapy in the management of craniopharyngiomas: further experiences and late results. Am J Roentgenol Radium Ther Nucl Med 103:44–52

    PubMed  CAS  Google Scholar 

  72. Kranzinger M, Jones N, Rittinger O, Pilz P, Piotrowski WP, Manzl M, Galvan G, Kogelnik HD (2001) Malignant glioma as a secondary malignant neoplasm after radiation therapy for craniopharyngioma: report of a case and review of reported cases. Onkologie 24:66–72

    Article  PubMed  CAS  Google Scholar 

  73. Kwon JW, Cho BK, Kim EC, Wang KC, Kim SK (2008) Herpes simplex encephalitis after craniopharyngioma surgery. J Neurosurg Pediatr 2:355–358

    Article  PubMed  Google Scholar 

  74. Lange M, Kirsch CM, Steude U, Oeckler R (1995) Intracavitary treatment of intrasellar cystic craniopharyngeomas with 90-Yttrium by trans-sphenoidal approach—a technical note. Acta Neurochir (Wien) 135:206–209

    Article  CAS  Google Scholar 

  75. Lichter AS, Wara WM, Sheline GE, Townsend JJ, Wilson CB (1977) The treatment of craniopharyngiomas. Int J Radiat Oncol Biol Phys 2:675–683

    Article  PubMed  CAS  Google Scholar 

  76. Lippens RJ, Rotteveel JJ, Otten BJ, Merx H (1998) Chemotherapy with Adriamycin (doxorubicin) and CCNU (lomustine) in four children with recurrent craniopharyngioma. Eur J Paediatr Neurol 2:263–268

    Article  PubMed  CAS  Google Scholar 

  77. Lonjon M, Dran G, Casagrande F, Vandenbos F, Mas JC, Richelme C (2005) Prenatal diagnosis of a craniopharyngioma: a new case with radical surgery and review. Childs Nerv Syst 21:177–180

    Article  PubMed  CAS  Google Scholar 

  78. Maira G, Anile C, Colosimo C, Cabezas D (2000) Craniopharyngiomas of the third ventricle: trans-lamina terminalis approach. Neurosurgery 47:857–863, discussion 863–855

    Article  PubMed  CAS  Google Scholar 

  79. Malik JM, Cosgrove GR, VandenBerg SR (1992) Remote recurrence of craniopharyngioma in the epidural space. Case report. J Neurosurg 77:804–807

    Article  PubMed  CAS  Google Scholar 

  80. Mason PW, Krawiecki N, Meacham LR (2002) The use of dextroamphetamine to treat obesity and hyperphagia in children treated for craniopharyngioma. Arch Pediatr Adolesc Med 156:887–892

    PubMed  Google Scholar 

  81. Matarazzo P, Genitori L, Lala R, Andreo M, Grossetti R, de Sanctis C (2004) Endocrine function and water metabolism in children and adolescents with surgically treated intra/parasellar tumors. J Pediatr Endocrinol Metab 17:1487–1495

    Article  PubMed  CAS  Google Scholar 

  82. Matthew DJ, Levin M (1986) Pulmonary thromboembolism in children. Intensive Care Med 12:404–406

    Article  PubMed  CAS  Google Scholar 

  83. McMurry FG, Hardy RW Jr, Dohn DF, Sadar E, Gardner WJ (1977) Long term results in the management of craniopharyngiomas. Neurosurgery 1:238–241

    Article  PubMed  CAS  Google Scholar 

  84. Merchant TE, Kiehna EN, Sanford RA, Mulhern RK, Thompson SJ, Wilson MW, Lustig RH, Kun LE (2002) Craniopharyngioma: the St. Jude Children’s Research Hospital experience 1984–2001. Int J Radiat Oncol Biol Phys 53:533–542

    Article  PubMed  Google Scholar 

  85. Merchant TE, Kiehna EN, Kun LE, Mulhern RK, Li C, Xiong X, Boop FA, Sanford RA (2006) Phase II trial of conformal radiation therapy for pediatric patients with craniopharyngioma and correlation of surgical factors and radiation dosimetry with change in cognitive function. J Neurosurg 104:94–102

    PubMed  Google Scholar 

  86. Miller ML, Kaufman BA, Lew SM (2008) Modified osteoplastic orbitozygomatic craniotomy in the pediatric population. Childs Nerv Syst 24:845–850

    Article  PubMed  Google Scholar 

  87. Mottolese C, Stan H, Hermier M, Berlier P, Convert J, Frappaz D, Lapras C (2001) Intracystic chemotherapy with bleomycin in the treatment of craniopharyngiomas. Childs Nerv Syst 17:724–730

    Article  PubMed  CAS  Google Scholar 

  88. Muller-Scholden J, Lehrnbecher T, Muller HL, Bensch J, Hengen RH, Sorensen N, Stockhausen HB (2000) Radical surgery in a neonate with craniopharyngioma. Report of a case. Pediatr Neurosurg 33:265–269

    Article  PubMed  CAS  Google Scholar 

  89. Nimsky C, Ganslandt O, Hofmann B, Fahlbusch R (2003) Limited benefit of intraoperative low-field magnetic resonance imaging in craniopharyngioma surgery. Neurosurgery 53:72–80, discussion 80–71

    Article  PubMed  Google Scholar 

  90. Niu DM, Guo WY, Pan HC, Wong TT (2002) Rapid enlargement of a residual craniopharyngioma during short-term growth hormone replacement. Childs Nerv Syst 18:164–165

    Article  PubMed  Google Scholar 

  91. Nomura H, Kurimoto M, Nagai S, Hayashi N, Hirashima Y, Tsukamoto E, Endo S (2002) Multiple intracranial seeding of craniopharyngioma after repeated surgery—case report. Neurol Med Chir (Tokyo) 42:268–271

    Article  Google Scholar 

  92. Novegno F, Di Rocco F, Colosimo C Jr, Lauriola L, Caldarelli M (2002) Ectopic recurrences of craniopharyngioma. Childs Nerv Syst 18:468–473

    Article  PubMed  Google Scholar 

  93. Ohmori K, Collins J, Fukushima T (2007) Craniopharyngiomas in children. Pediatr Neurosurg 43:265–278

    Article  PubMed  Google Scholar 

  94. Park DH, Park JY, Kim JH, Chung YG, Lee HK, Lee KC, Suh JK (2002) Outcome of postoperative intratumoral bleomycin injection for cystic craniopharyngioma. J Korean Med Sci 17:254–259

    PubMed  CAS  Google Scholar 

  95. Pekmezci M, Louie J, Gupta N, Bloomer MM, Tihan T (2010) Clinicopathological characteristics of adamantinomatous and papillary craniopharyngiomas: University of California, San Francisco experience 1985–2005. Neurosurgery 67:1341–1349, discussion 1349

    Article  PubMed  Google Scholar 

  96. Plowman PN, Wraith C, Royle N, Grossman AB (1999) Stereotactic radiosurgery. IX. Craniopharyngioma: durable complete imaging responses and indications for treatment. Br J Neurosurg 13:352–358

    Article  PubMed  CAS  Google Scholar 

  97. Ramnarayan R, Sreehari NR, Ninan GK, John KM (2007) Delayed postoperative extradural hematoma. Pediatr Neurosurg 43:113–114

    Article  PubMed  CAS  Google Scholar 

  98. Rilliet B, Vernet O, Pica A (2005) The Geneva and Lausanne (French-speaking Switzerland) experience: in favor of the transsphenoidal approach when feasible. Childs Nerv Syst 21:725–728

    Article  PubMed  Google Scholar 

  99. Rodriguez FJ, Scheithauer BW, Tsunoda S, Kovacs K, Vidal S, Piepgras DG (2007) The spectrum of malignancy in craniopharyngioma. Am J Surg Pathol 31:1020–1028

    Article  PubMed  Google Scholar 

  100. Sanford RA (1994) Craniopharyngioma: results of survey of the American Society of Pediatric Neurosurgery. Pediatr Neurosurg 21(Suppl 1):39–43

    Article  PubMed  Google Scholar 

  101. Schmalisch K, Beschorner R, Psaras T, Honegger J (2010) Postoperative intracranial seeding of craniopharyngiomas—report of three cases and review of the literature. Acta Neurochir (Wien) 152:313–319, discussion 319

    Article  Google Scholar 

  102. Sener RN, Kismali E, Akyar S, Selcuki M, Yalman O (1997) Large craniopharyngioma extending to the posterior cranial fossa. Magn Reson Imaging 15:1111–1112

    Article  PubMed  CAS  Google Scholar 

  103. Serowka K, Chiu Y, Gonzalez I, Gilles F, McComb G, Krieger M, Dhall G, Britt B, Ji L, Sposto R, Finlay JL (2010) Central nervous system (CNS) tumors in the first 6 months of life: the Children’s Hospital Los Angeles experience, 1979–2005. Pediatr Hematol Oncol 27:90–102

    Article  PubMed  CAS  Google Scholar 

  104. Shinohara O, Shinagawa T, Kubota C, Oi S (1997) Spontaneous reduction of a recurrent craniopharyngioma in an 8-year-old female patient: case report. Neurosurgery 41:1188–1190

    Article  PubMed  CAS  Google Scholar 

  105. Shirane R, Ching-Chan S, Kusaka Y, Jokura H, Yoshimoto T (2002) Surgical outcomes in 31 patients with craniopharyngiomas extending outside the suprasellar cistern: an evaluation of the frontobasal interhemispheric approach. J Neurosurg 96:704–712

    Article  PubMed  Google Scholar 

  106. Shirane R, Hayashi T, Tominaga T (2005) Fronto-basal interhemispheric approach for craniopharyngiomas extending outside the suprasellar cistern. Childs Nerv Syst 21:669–678

    Article  PubMed  Google Scholar 

  107. Shuman AG, Heth JA, Marentette LJ, Blaivas M, Muraszko KM (2007) Extracranial nasopharyngeal craniopharyngioma: case report. Neurosurgery 60:E780–E781, discussion E781

    Article  PubMed  Google Scholar 

  108. Siomin V, Spektor S, Beni-Adani L, Constantini S (2001) Application of the orbito-cranial approach in pediatric neurosurgery. Childs Nerv Syst 17:612–617

    Article  PubMed  CAS  Google Scholar 

  109. Srinivasan J, Dailey AT, Berger MS (1999) The bifrontal olfactory nerve-sparing approach to lesions of the suprasellar region in children. Pediatr Neurosurg 30:245–252

    Article  PubMed  CAS  Google Scholar 

  110. Strenger V, Sovinz P, Lackner H, Dornbusch HJ, Lingitz H, Eder HG, Moser A, Urban C (2008) Intracerebral cavernous hemangioma after cranial irradiation in childhood. Incidence and risk factors. Strahlenther Onkol 184:276–280

    Article  PubMed  Google Scholar 

  111. Sutton LN, Gusnard D, Bruce DA, Fried A, Packer RJ, Zimmerman RA (1991) Fusiform dilatations of the carotid artery following radical surgery of childhood craniopharyngiomas. J Neurosurg 74:695–700

    Article  PubMed  CAS  Google Scholar 

  112. Taguchi Y, Tanaka K, Miyakita Y, Sekino H, Fujimoto M (2000) Recurrent craniopharyngioma with nasopharyngeal extension. Pediatr Neurosurg 32:140–144

    Article  PubMed  CAS  Google Scholar 

  113. Takahashi H, Yamaguchi F, Teramoto A (2005) Long-term outcome and reconsideration of intracystic chemotherapy with bleomycin for craniopharyngioma in children. Childs Nerv Syst 21:701–704

    Article  PubMed  Google Scholar 

  114. Thompson IL, Griffin TW, Parker RG, Blasko JC (1978) Craniopharyngioma: the role of radiation therapy. Int J Radiat Oncol Biol Phys 4:1059–1063

    Article  PubMed  CAS  Google Scholar 

  115. Trejos H, Caceres A, Segura JL (2005) Monstrous craniopharyngioma. Case presentations and term proposal. Childs Nerv Syst 21:1049–1053, discussion 1054–1045

    Article  PubMed  Google Scholar 

  116. Tsutsumi S, Yasumoto Y, Ito M (2008) Central pontine and extrapontine myelinolysis in an infant associated with the treatment of craniopharyngioma: case report. Neurol Med Chir (Tokyo) 48:351–354

    Article  Google Scholar 

  117. Ulfarsson E, Lindquist C, Roberts M, Rahn T, Lindquist M, Thoren M, Lippitz B (2002) Gamma knife radiosurgery for craniopharyngiomas: long-term results in the first Swedish patients. J Neurosurg 97:613–622

    PubMed  Google Scholar 

  118. Usanov EI, Hatomkin DM, Nikulina TA, Gorban NA (1999) Craniopharyngioma of the pineal region. Childs Nerv Syst 15:4–7

    Article  PubMed  CAS  Google Scholar 

  119. Vyramuthu N, Benton TF (1983) The management of craniopharyngioma. Clin Radiol 34:629–632

    Article  PubMed  CAS  Google Scholar 

  120. Weiner HL, Wisoff JH, Rosenberg ME, Kupersmith MJ, Cohen H, Zagzag D, Shiminski-Maher T, Flamm ES, Epstein FJ, Miller DC (1994) Craniopharyngiomas: a clinicopathological analysis of factors predictive of recurrence and functional outcome. Neurosurgery 35:1001–1010, discussion 1010–1001

    Article  PubMed  CAS  Google Scholar 

  121. Yasargil MG, Curcic M, Kis M, Siegenthaler G, Teddy PJ, Roth P (1990) Total removal of craniopharyngiomas. Approaches and long-term results in 144 patients. J Neurosurg 73:3–11

    Article  PubMed  CAS  Google Scholar 

  122. Zhou L, Luo L, Xu J, Li Q, Chen J, Jiang S, Cai B, You C (2009) Craniopharyngiomas in the posterior fossa: a rare subgroup, diagnosis, management and outcomes. J Neurol Neurosurg Psychiatry 80:1150–1154

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurological Surgery, Pediatric Neurosurgery, University of California, San Francisco, 505 Parnassus Ave., M779, Box 0112, San Francisco, CA, 94143-0112, USA

    Aaron J. Clark, Tene A. Cage, Derick Aranda, Andrew T. Parsa, Kurtis I. Auguste & Nalin Gupta

  2. Children’s Hospital and Research Center, Oakland, CA, USA

    Peter P. Sun & Kurtis I. Auguste

Authors
  1. Aaron J. Clark
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tene A. Cage
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Derick Aranda
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Andrew T. Parsa
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Peter P. Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kurtis I. Auguste
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Nalin Gupta
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nalin Gupta.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Clark, A.J., Cage, T.A., Aranda, D. et al. A systematic review of the results of surgery and radiotherapy on tumor control for pediatric craniopharyngioma. Childs Nerv Syst 29, 231–238 (2013). https://doi.org/10.1007/s00381-012-1926-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00381-012-1926-2

Keywords

Search

Navigation