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Therapiealternativen zur chirurgischen Versorgung maligner Lidtumoren und deren Vorläuferstufen

Therapeutic alternatives to surgical treatment of malignant eyelid tumors and their precursors

  • Das diagnostische und therapeutische Prinzip
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Zusammenfassung

Therapie der Wahl maligner Lidtumoren ist die chirurgische Exzision. Falls dies nicht möglich oder gewünscht ist, steht eine Reihe alternativer Therapien zur Verfügung. Als systemische Präparate kommen für Basalzellkarzinome Vismodegib und Sonidegib, für Plattenepithelkarzinome Cetuximab und Cemiplimab infrage. Bei oberflächlichen Tumoren ist eine Kryodestruktion möglich. In-situ-Befunde können mit den lokalen Präparaten Imiquimod oder 5‑Fluoruracil sowie mit der photodynamischen Therapie behandelt werden. Die interdisziplinäre Zusammenarbeit mit Kollegen der Dermatologie ist empfehlenswert.

Abstract

The treatment of choice for malignant eyelid tumors is surgical excision. If this is not feasible or undesirable, a number of alternative treatments are available. Possible systemic preparations are vismodegib and sonidegib for basal cell carcinoma as well as cetuximab and cemiplimab for squamous cell carcinoma. Cryodestruction is possible for superficial tumors. In situ findings can be treated with the local preparations imiquimod or 5‑fluorouracil and with photodynamic therapy. An interdisciplinary cooperation with dermatologists is advisable.

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Authors and Affiliations

  1. Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Leipzig AöR, Liebigstr. 10–14, 04103, Leipzig, Deutschland

    C. Girbardt FEBO, A. Mößner & P. Wiedemann

  2. Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Leipzig AöR, Leipzig, Deutschland

    S. Grunewald

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  1. C. Girbardt FEBO
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  2. A. Mößner
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  4. S. Grunewald
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Correspondence to C. Girbardt FEBO.

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C. Girbardt, A. Mößner, P. Wiedemann und S. Grunewald geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. Für Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, über die Patienten zu identifizieren sind, liegt von ihnen und/oder ihren gesetzlichen Vertretern eine schriftliche Einwilligung vor.

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Girbardt, C., Mößner, A., Wiedemann, P. et al. Therapiealternativen zur chirurgischen Versorgung maligner Lidtumoren und deren Vorläuferstufen. Ophthalmologe 117, 478–483 (2020). https://doi.org/10.1007/s00347-020-01072-y

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