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Chemotherapie des Basalioms

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Dermatologische Onkologie

Zusammenfassung

Als sicherste Behandlungsmethode des Basalioms gilt heute die Exzision des Tumors im Gesunden. Sie verspricht eine zuverlässige Heilung bei über 95% der operierten Fälle und wird in entsprechend gelagerten Problemfällen (Rezidive, sklerodermiforme Basaliome, Problemlokalisationen) als mikroskopisch kontrollierte Chirurgie durchgeführt [43].

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Literatur

  1. Assar D (1967) Basal cell carcinoma with metastases to bone: report of two cases. Cancer 20: 2125–2132

    Article  Google Scholar 

  2. Baxter DL, Plummer Joyce A, Feldman BD, Lynch JW (1990) Cisplatin chemotherapy for basal cell carcinoma: the need for posttreatment biopsy - report of a case. J Am Acad Dermatol 23: 1167–1168

    Article  PubMed  Google Scholar 

  3. Boneschi V, Brambilla L, Chiappino G et al. (1991) Intralesional alpha 2a recombinant interferon for basal cell carcinama. Int J Dermatol 30: 220–224

    Article  PubMed  CAS  Google Scholar 

  4. Briggs RM, Pestana I (1979) Long-tem survival in basal cell carcinoma metastatic to bone: a case report. Ann Plast Surg 3: 549–554

    Article  PubMed  CAS  Google Scholar 

  5. Carruth JAS, McKenzie AL (1985) Preliminary report of a pilot study of photoradiation therapy for the treatment of superficial malignancies of the skin, head and neck. Eur J Surg Oncol 11: 47–50

    PubMed  CAS  Google Scholar 

  6. Chang BK, Guthrie TH, Hayakawa K, Gangarosa LP (1993) A pilot study of iontophoretic Cisplatin chemotherapy of basal and squamous cell carcinomas of the skin. Arch Dermatol 129: 425–427

    Article  PubMed  CAS  Google Scholar 

  7. Chawla SP, Benjamin RS, Ayala AG et al. (1989) Advanced basal cell carcinoma and successful treatment with chemotherapy. J Surg Oncol 40: 68–72

    Article  PubMed  CAS  Google Scholar 

  8. Chien WL (1966) Basal cell carcinoma with metastases to bones and lung. Va Med 93: 14–17

    Google Scholar 

  9. Chimenti S, Peris K, Di Cristofaro S, Fargnoli MC, Torlone G (1995) Use of recombinant interferon alfa-2b in the treatment of basal cell carcinom. Dermatology 190: 214–217

    Article  PubMed  CAS  Google Scholar 

  10. Christensen M, Briggs RM, Cobleutz MG et al. (1978) Metastatic basal cell carcinoma: a review of the literature and report of cases. Am Surg 44: 382–387

    PubMed  CAS  Google Scholar 

  11. Cieplinski W (1984) Combination chemotherapy for the treatment of metastatic basal cell carcinoma of the scrotum. A case report. Clin Oncol 10: 267–272

    PubMed  CAS  Google Scholar 

  12. Coker DD, Elias EG, Viravathana T, McCrea E, Hafiz M (1983) Chemotherapy for metastatic basal cell carcinoma. Arch Dermatol 119: 44–50

    Article  PubMed  CAS  Google Scholar 

  13. Cornell RC, Greenway HT, Tucker SB et al. (1990) Intralesional interferon therapy for basal cell carcinoma. J Am Acad Dermatol 23: 694–700

    Article  PubMed  CAS  Google Scholar 

  14. Costanza ME, Dayal YT, Binder S, Nathanson L (1974) Metastatic basal cell carcinoma: review, report of a case and chemotherapy. Cancer 34: 230–235

    Article  PubMed  CAS  Google Scholar 

  15. Cotran RS (1961) Metastasizing basal cell carcinomas. Cancer 14: 1036–1040

    Article  PubMed  CAS  Google Scholar 

  16. Cristofolini M, Zuminani G, Scapinni A et al. (1984) Aromatic retinoid chemoprevention of the progression of nevoid basal cell carcinoma syndrome. J Dermatol Surg Oncol 10: 778–781

    PubMed  CAS  Google Scholar 

  17. Curry MC, Montgomery H, Winkelmann RK (1977) Giant basal cell carcinoma. Arch Dermatol 113: 316–319

    Article  PubMed  CAS  Google Scholar 

  18. Dickie GJ, Pratt GR (1988) Basal cell carcinoma of the skin responding completely to chemotherapy (letter). Arch Dermatol 124: 494

    Article  PubMed  CAS  Google Scholar 

  19. DiLorenzo PA, Goodman N, Lansville F, Markel W (1994) Regional and intralesional treatment of invasive basal cell carcinoma with interferon alfa-2b. J Am Acad Dermatol 31: 109–111

    Article  PubMed  CAS  Google Scholar 

  20. Dogan B, Harmanyiery Y, Baloglu H, Oztek I (1995) Intralesional alfa-2a interferon therapy of basal cell carcinoma. Cancer Lett 91: 215–219

    Article  PubMed  CAS  Google Scholar 

  21. Domarus HR, Stevens PJ (1984) Metastatic basal cell carcinoma: report of five cases and review of 170 cases in the literature. J Am Acad Dermatol 10: 1043–1060

    Article  Google Scholar 

  22. Dummer R, Krasovec M, Roger J, Sindermann H, Burg G (1993) Topical application of hexadecylphocholine in patients with cutaneous lymphomas: results of a phase I/II study. J Am Acad Dermatol 29: 963–970

    Article  PubMed  CAS  Google Scholar 

  23. Edwards L, Whiting D, Rogers D, Luck K, Smiles K (1990) The effect of intralesional interferon gamma on basal cell carcinomas. J Am Acad Dermatol 22: 496–500

    Article  PubMed  CAS  Google Scholar 

  24. Edwards L, Tucker SB, Perednia D et al. (1990) The effect of an intralesional sustained-release formulation of interferon alpha-2b on basal cell carcinoma. Arch Dermatol 126: 1029–1032

    Article  PubMed  CAS  Google Scholar 

  25. Farmer ER, Helwig EB (1980) Metastatic basal cell carcinoma: a clinicopathologic study of seventeen cases. Cancer 46: 748–757

    Article  PubMed  CAS  Google Scholar 

  26. Glass LF, Fenske NA, Jaroszeski M, Perrott R, Harvey DT, Reintgen DS, Heller R (1996) Bleomycin-mediated electrochemotherapy of basal cell carcinoma. J Am Acad Dermatol 34: 82–86

    Article  PubMed  CAS  Google Scholar 

  27. Glassberg E, Lewandowski L, Lask G, Uitto J (1990) Laser induced photodynamic therapy with aluminium phtalocyanine tetrasulftonate as the photosensitizer: differential phototoxicity in normal and malignant human cells in vitro. J Invest Dermatol 94: 604–610

    Article  PubMed  CAS  Google Scholar 

  28. Greenway HT, Cornell RC, Tanner DJ, Peets E, Bordin GM, Nagi C (1986) Treatment of basal cell carcinoma with intralesional interferon. J Am Acad Dermatol 15: 437–443

    Article  PubMed  CAS  Google Scholar 

  29. Grob JJ, Collet AM, Munoz MH, Bonderandi JJ (1988) Treatment of large basal cell carcinomas with intralesional interferon-alpha-2a. Lancet I (8590): 878–879

    Article  Google Scholar 

  30. Guthrie TH, McElveen LJ, Porubsky ES, Harmon JD (1985) Cisplatin and doxorubicin. An effective chemotherapy combination in the treatment of advanced basal cell and squamous carcinoma of the skin. Cancer 55: 1629

    Article  PubMed  Google Scholar 

  31. Hall TE, Tappau WM, Decker JW (1970) Basal cell carcinoma with metastases: report of two cases. Rocky Mt Med J 67: 38–40

    Google Scholar 

  32. Hughes BR, Marks R, Pearse A, Gaskell SA (1986) Clinical response and tissue effects of etretinate treatment of patients with solar keratosis and basal cell carcinoma. J Am Acad Dermatol 18: 522–529

    Article  Google Scholar 

  33. Hodak E, Ginzburg A, David M, Sandbank M (1987) Etretinate treatment of the nevoid basal cell carcinoma syndrome. Int J Dermatol 26: 606–609

    Article  CAS  Google Scholar 

  34. Ikeda S, Suzuki T, Kiyohara Y, Kuramochi A (1993) Squamous cell carcinoma, basal cell carcinoma. Gan To Kagaku Ryoho 20: 1293–1301

    PubMed  CAS  Google Scholar 

  35. Ikic D, Padovan I, Pipic N et al. (1995) Interferon reduces recurrences of basal cell and squamous cell cancers. Int J Dermatol 34: 58–60

    Article  PubMed  CAS  Google Scholar 

  36. Jagar RM, Weiner LJ, Howell RS (1977) Basal cell carcinoma with bony metastases producing myelofibrosis. Arch Dermatol 113: 1288–1289

    Article  Google Scholar 

  37. Kaufman D, Gralla R, Myskowski PL (1988) Basal cell carcinoma: response to systemic chemotherapy for lung carcinoma. J Am Acad Dermatol 18: 30–310

    Article  Google Scholar 

  38. Kaufmann R (1993) Chemotherapie beim Basaliom ? In: Petres J, Lohrisch I (Hrsg) Das Basaliom (S 213–220). Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  39. Khandekar JD (1990) Complete response of metastatic basal cell carcinoma to cisplatin chemotherapy: a report on two patients. Arch Dermatol 126: 1660

    Article  PubMed  CAS  Google Scholar 

  40. Klostermann GF (1970) Effects of 5-FU Ointment in normal and diseased skin, histological findings and deep action. Dermatologica [Suppl 140/1: 47–54

    Article  PubMed  Google Scholar 

  41. Kord JP, Cottel WI, Proper S (1982) Metastatic basal cell carcinoma. J Dermatol Surg Oncol 8: 604–608

    PubMed  CAS  Google Scholar 

  42. Landes E (1981) Lokale Chemotherapie der Basaliome. In: Eichmann F, Schnyder UW (Hrsg) Das Basaliom - Der häufigste Tumor der Haut (S 129–134). Springer, Berlin Heidelberg New York

    Google Scholar 

  43. Lawrence CM: Mohs surgery of basal cell carcinoma - a critical review. Br J Plast Surg 46: 599–606

    Google Scholar 

  44. LeGrice P, Baird E, Hodge L (1995) Treatment of basal cell carcinoma with intralesional interferon alpha-2a (letter) N Z Med J 108: 206–207

    PubMed  CAS  Google Scholar 

  45. Lippmann SM, Meyskens FL Jr (1992) 13-cisretinoic acid and interferon α2a: effective combination therapy for advanced squamous cell carcinoma of the skin. J Natl Cancer Inst 84: 235–241

    Article  Google Scholar 

  46. Luxenburg MN, Guthrie TU (1986) Chemotherapy of basal cell and squamous cell carcinoma of the eyelids and periorbital tissues. Ophthalmology 93: 504–510

    Google Scholar 

  47. Martin A, Tope WD, Grevelink JM et al. (1995) Lack of selectivity of porphyrin IX fluorescence for basal cell carcinoma after topical application of 5-aminolevulinic acid: implications for photodynamic treatment. Arch Dermatol Res 287: 665–674

    Article  PubMed  CAS  Google Scholar 

  48. McDonalds RR, Georgouras K (1992) Treatment of basal cell carcinoma with intralesional interferon alpha: a case report and literature review. Australas J Dermatol 33: 81–86

    Article  Google Scholar 

  49. Merimsky O, Neudorfer M, Spitzer E, Chaitchik S (1992) Salvage cisplatin and adriamycin for advanced or recurrent basal or squamous cell carcinoma of the face. Anticancer Drugs 3: 481–484

    Article  PubMed  CAS  Google Scholar 

  50. Mikhail GR, Nims LP, Kelly AP Jr et al. (1977) Metastatic basal cell carcinoma. Arch Dermatol 113: 1261–1269

    Article  PubMed  CAS  Google Scholar 

  51. Mohs FE (1976) Chemosurgery for skin cancer: fixed and fresh tissue techniques. Arch Dermatol 112: 211–215

    Article  PubMed  CAS  Google Scholar 

  52. Moore DM, Kalvakolanu DV, Lippmann SM et al. (1995) Retinoic acid and interferon in human cancer: mechanistic and clinical studies. Semin Hematol [Suppl] 31/5: 31–37

    Google Scholar 

  53. Murphy KJ (1975) Metastatic basal cell carcinoma with squamous appearances in the naevoid basal cell carcinoma syndrome. J Plast Surg 28:331–334

    Article  CAS  Google Scholar 

  54. Neudorfer M, Mermsky O, Lazar M, Geyer O (1993) Cisplatin and doxorubicin for invasive basal cell carcinoma of the eyelids. Ann Ophthalmol 25: 11–13

    PubMed  CAS  Google Scholar 

  55. Ohrenberg EK, Miller BH, Greenway HT et al. (1992) The effect of intralesional 5-fluorouracil therapeutic implant (MPI 5003) for treatment of basal cell carcinoma. J Am Acad Dermatol 27: 723–728

    Article  Google Scholar 

  56. Paver K, Poyzer K, Burry N et al. (1973) The incidence of basal cell carcinoma and their metastases in Australia and New Zealand. Australas J Dermatol 14: 53

    Article  PubMed  CAS  Google Scholar 

  57. Peck GL, Gross EG, Butkus D, Di Giovanna JJ (1982) Chemoprevention of basal cell carcinoma with isotretinoin. J Am Acad Dermatol 6: 815–823

    Article  PubMed  CAS  Google Scholar 

  58. Peck GL (1987) Long-term retinoid therapy is needed for maintanance of cancer chemopreventive effect. Dermatologica [Suppl] 175/1: 138–144

    Article  PubMed  Google Scholar 

  59. Peck GL, Di Giovanna JJ, Sarnoff DS et al. (1988) Treatment and prevention of basal cell carcinoma with oral isotretinoin. J Am Acad Dermatol 19: 176–185

    Article  PubMed  CAS  Google Scholar 

  60. Peng Q, Warloe T, Moan J, Heyerdhl H, Steen HB, Nelsalnd JM, Giercksky KE (1995) Distribution of 5-aminolevulinic acid-induced porphyrins in noduloulcerative basal cell carcinoma. Photochem Photobiol 62: 906–913

    Article  PubMed  CAS  Google Scholar 

  61. Pennington DG, Waner M, Knox A (1988) Photodynamic therapy for multiple skin cancer. Plast Reconstr Surg 82: 1067–1071

    Article  PubMed  CAS  Google Scholar 

  62. Pfeiffer P, Hansen O, Rose C (1990) Systemic cytotoxic therapy of basal cell carcinoma. A review of the literature. Eur J Cancer 26: 73–77

    Article  PubMed  CAS  Google Scholar 

  63. Pfister R (1977) Antibiotische Behandlung maligner epithelialer Tumoren. Fortschr Med 12: 784–787

    Google Scholar 

  64. Remy W, Schober C (1991) Intratumorale Applikation von Interferonen bei Basaliomen. Zbl Haut 158: 854

    Google Scholar 

  65. Reyman F (1979) Treatment of basal cell carcinoma of the skin with 5-Fluorouracil ointment. A 10 year follow up study. Dermatologica 158: 368–372

    Article  Google Scholar 

  66. Robinson JK (1987) Use of a combination of chemotherapy and radiation therapy in the management of advanced basal cell carcinoma of the head and neck. J Am Acad Dermatol 17: 770–774

    Article  PubMed  CAS  Google Scholar 

  67. Sacchini V, Melloni E, Marchesini R, Luini A, Bandieramonte G, Spinelli P, Cascinelli N (1987) Preliminary clinical studies with PDT by topical TPPS administration in neoplastic skin lesions. Las Surg Med 7: 6–11

    Article  CAS  Google Scholar 

  68. Safai B, Good RA (1977) Basal cell carcinoma with metastasis: a review of literature. Arch Pathol Lab Med 101: 327–331

    PubMed  CAS  Google Scholar 

  69. Sahl WR Jr, Snow SN, Levine NS (1994) Giant basal cell carcinoma. Report of two cases and review of the literature. J Am Acad Dermatol 30: 856–859

    Article  PubMed  Google Scholar 

  70. Sakula A (1977) Pulmonary metastases from basal cell carcinoma of skin. Thorax 32: 637–642

    Article  PubMed  CAS  Google Scholar 

  71. Salem P, Hall SW, Benjamin RS, Murphy WK, Wharton JT, Bodey GP (1978) Clinical phase I-II study of cis-dichloro-diamineplatinum (II) given by continuous i.v. infusion. Cancer Treat Rep 62: 1553–1555

    PubMed  CAS  Google Scholar 

  72. Sanchez-Conejo-Mir: Nevoid basal cell carcinoma syndrome: combined etretinate and surgical treatment. J Dermatol Surg Oncol 15: 868–871

    Google Scholar 

  73. Santoro O, Bandieramonte G, Melloni E, Marchesini R, Zunino F, Lepera P, De Palo G (1990) Photodynamic therapy by topical meso-tetraphenylprohyrinesulfonate tetra-sodium salt administration in superficial basal cell carcinomas. Cancer Res 50: 4501–4503

    PubMed  CAS  Google Scholar 

  74. Scanlon EF, Volkmer DD, Oviedo MA, Khandekar JD; Victor TA (1980) Metastatic basal cell carcinoma. J Surg Oncol 15: 171–180

    Article  PubMed  CAS  Google Scholar 

  75. Schnitzler L, Schubert BV, Verret JL (1980) Evaluation of oral retinoid preventive action on human cutaneous epitheliomas. Ann Dermatol Venereol 107: 657–663

    PubMed  CAS  Google Scholar 

  76. Schreus HT (1951) Chlorzinkschnellatzung des Epithelioms. Hautarzt 2: 317–319

    Google Scholar 

  77. Shavin J, Cognetta A, Buchanan S et al. (1995) Treatment of basal cell carcinoma with AccuSite TM(fluorouracil/epinephrine) injectable gel results in high cure rates: multi-center phase II study. JEADV [Suppl] 5/1: 117

    Google Scholar 

  78. Shiell A (1994) Consideration of the cost of interferon alfa-2b in the treatment of basal cell carcinoma. Australas J Dermatol 35: 71–75

    Article  PubMed  CAS  Google Scholar 

  79. Stanislav AB (1991) Intralesional interferon alpha-2b in the treament of basal cell carcinoma. J Am Acad Dermatol 24: 731–734

    Article  Google Scholar 

  80. Szeimies RM, Landthaler M (1995) Topische photodynamische Therapie in der Behandlung oberflächlicher Hauttumoren. Hautarzt 46: 315–318

    Article  PubMed  CAS  Google Scholar 

  81. Tangrea JA, Adrianza E, Heisel WE (1993) Clinical and laboratory adverse effects associated with longterm, lowdose isotretinoin: incidence and risk factors. The Isotretinoin - Basal Cell Carcinoma Study Group. Cancer Epidemiol Biomarkers Prev 2: 375–380

    PubMed  CAS  Google Scholar 

  82. Van Scott EJ, Shaw RK, Crounse RG, Condit PT (1960) Effects fo methotrexate on basal cell carcinomas. Arch Dermatol 82: 762–771

    Google Scholar 

  83. Vico P, Nemec E, Andry G, Deraermaecker R (1995) Aggressive basal cell carcinoma of head and neck area. Eur J Surg Oncol 21: 490–497

    PubMed  CAS  Google Scholar 

  84. Vigliola PA (1980) Therapeutic evaluation of the oral retinoid Ro 10–9359 in several non-psoriatic dermatoses. Br J Dermatol 103: 483–487

    Article  Google Scholar 

  85. White H (1975) Two cases of metastasizing basal cell carcinoma. Clin Oncol 1: 149–155

    PubMed  CAS  Google Scholar 

  86. Wieman TJ, Shively EH, Woodcock TM (1983) Responsiveness of metastatic basal cell carcinoma to chemotherapy. A case report. Cancer 52: 1583–1585

    Article  PubMed  CAS  Google Scholar 

  87. Woods RL, Stewart JF (1980) Metastatic basal cell carcinoma: report of a case responding to chemotherapy. Postgrad Med J 56: 272–273

    Article  PubMed  CAS  Google Scholar 

  88. Zala A (1972) Histologische Befunde bei Behandlung von Hautneoplasien mit 5-Fluorouracil Salbe. Dermatologica 145: 326–333

    Article  PubMed  CAS  Google Scholar 

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Kaufmann, R. (1997). Chemotherapie des Basalioms. In: Garbe, C., Dummer, R., Kaufmann, R., Tilgen, W. (eds) Dermatologische Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60622-9_15

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