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Immunsuppression nach Keratoplastik

Klinische Standards und neue Ansätze

Immunosuppression after corneal transplantation

Clinical standards and novel approaches

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Zusammenfassung

Nach lamellärer und perforierender Keratoplastik werden glukokortikoidhaltige Augentropfen zur Immunsuppression eingesetzt. Häufige Medikamentennebenwirkungen sind Augendruckerhöhung und Katarakt. Alternative immunsuppressive Medikamente könnten eine Verringerung der Glukokortikoiddosis erlauben. Ein möglicher Wirkstoff ist das Antibiotikum Azithromycin, das im Zellkultur- und Tiermodell an der Hornhaut entzündungshemmend wirkt und die Transplantatabstoßung begrenzt.

Abstract

Corticosteroid eye drops are the mainstay of immunosuppressive therapy after routine lamellar and perforating corneal transplantation. Commonly occurring side effects are cataract formation and increased intraocular pressure. Alternative immunosuppressive agents could allow the dosage of glucocorticoids to be reduced. The antibiotic azithromycin is a candidate drug that showed anti-inflammatory properties in cell cultures and animal models and has positive effects on transplant rejection.

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Authors and Affiliations

  1. Klinik für Augenheilkunde, Universitätsklinikum Freiburg, Killianstr. 5, 79106, Freiburg im Breisgau, Deutschland

    K. Wacker & T. Reinhard

Authors
  1. K. Wacker
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  2. T. Reinhard
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Correspondence to K. Wacker.

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Interessenkonflikt

K. Wacker und T. Reinhard erhielten finanzielle Unterstützung für Labormaterialien zur Untersuchung der Transplantatabstoßung von der Firma Laboratoires Théa, Frankreich [11]. Die Firma war nicht an der Datenerhebung, Datenanalyse oder der Entscheidung zur Publikation beteiligt.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Wacker, K., Reinhard, T. Immunsuppression nach Keratoplastik. Ophthalmologe 113, 432–434 (2016). https://doi.org/10.1007/s00347-016-0268-y

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  • DOI: https://doi.org/10.1007/s00347-016-0268-y

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