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Controlled synthesis of Ag/CuO nanocomposites: evaluation of their antimycobacterial, antioxidant, and anticancer activities

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Abstract

Herein we summarize the production of silver/copper oxide nanocomposites (Ag/CuO NCs) by a facile solution combustion method with the aid of abio-fuel as reductant. Powder XRD results revealed the formation of Ag/CuO NCs with average crystallite size ranging from 20 to 25 nm. These NCs were tested for their antimycobacterial activity against four mycobacterium species namely Mycobacterium tuberculosis H37Rv ATCC 27294, Mycobacterium abscessus ATCC 19977, Mycobacterium fortuitum ATCC 6841, Mycobacterium chelonae ATCC and anticarcinogenic activity on breast cancer cell line MDA-MB-231. Scavenging activity was evaluated by the 2, 2-diphenyl-1-picrylhydrazyl hydrate (DPPH) method. Results indicated that the Ag/CuO NCs had higher anticancer and slightly better scavenging activities than the undoped CuO nanoparticles.

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Acknowledgements

The authors acknowledge TIFR, Mumbai for Powder XRD, IIT Mandi for FESEM and elemental mapping and CDRI, Lucknow for carrying out the antimycobacterial studies.

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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Chemistry, Sir M. Visvesvaraya Institute of Technology (Affiliated to Visvesvaraya Technological University, Belagavi-590 018, India), Bengaluru, 562157, India

    G. K. Prashanth & H. M. Sathyananda

  2. Centre for Research and Evaluation, Bharathiar University, Coimbatore, 641 046, India

    G. K. Prashanth, H. M. Sathyananda & P. A. Prashanth

  3. Department of Chemistry, PES College of Engineering (Affiliated to Visvesvaraya Technological University, Belagavi-590 018, India), Mandya, 571401, India

    P. A. Prashanth

  4. Department of Pharmacology, School of Medical and Allied Sciences, KR Mangalam University, Gurgaon, 122103, India

    Manoj Gadewar

  5. Department of Chemistry, Sai Vidya Institute of Technology (Affiliated to Visvesvaraya Technological University, Belagavi-590 018, India), Bengaluru, 560 064, India

    M. Mutthuraju

  6. Department of ECE, Surya Engineering College, Mettukadai, 638107, India

    S. R. Boselin Prabhu

  7. Department of Chemistry, M.S. Ramaiah Institute of Technology (Affiliated to Visvesvaraya Technological University, Belagavi-590 018, India), Bengaluru, 560054, India

    B. M. Nagabhushana

  8. Solid State and Structural Chemistry Unit, Indian Institute of Science, Bengaluru, 560012, India

    C. Shivakumara

  9. Department of Chemistry, Nitte Meenakshi Institute of Technology (Affiliated to Visvesvaraya Technological University, Belagavi-590 018, India), Bengaluru, 560 064, India

    Srilatha Rao

  10. Department of Pharmaceutics School of Pharmacy, Anurag University, Hyderabad, 500088, Telangana, India

    Dibyalochan Mohanty

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Prashanth, G.K., Sathyananda, H.M., Prashanth, P.A. et al. Controlled synthesis of Ag/CuO nanocomposites: evaluation of their antimycobacterial, antioxidant, and anticancer activities. Appl. Phys. A 128, 614 (2022). https://doi.org/10.1007/s00339-022-05748-x

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