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Antibacterial properties of Ag-doped hydroxyapatite layers prepared by PLD method

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Abstract

Thin hydroxyapatite (HA), silver-doped HA and silver layers were prepared using a pulsed laser deposition method. Doped layers were ablated from silver/HA targets. Amorphous and crystalline films of silver concentrations of 0.06 at.%, 1.2 at.%, 4.4 at.%, 8.3 at.% and 13.7 at.% were synthesized. Topology was studied using scanning electron microscopy and atomic force microscopy. Contact angle and zeta potential measurements were conducted to determine the wettability, surface free energy and electric surface properties. In vivo measurement (using Escherichia coli cells) of antibacterial properties of the HA, silver-doped HA and silver layers was carried out. The best antibacterial results were achieved for silver-doped HA layers of silver concentration higher than 1.2 at.%.

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Authors and Affiliations

  1. Institute of Physics ASCR v.v.i., Na Slovance 2, 18221, Prague 8, Czech Republic

    Miroslav Jelínek, Tomáš Kocourek, Karel Jurek, Jan Remsa & Jan Mikšovský

  2. Faculty of Biomedical Engineering, Czech Technical University in Prague, Sítná 3105, Kladno, Czech Republic

    Miroslav Jelínek, Tomáš Kocourek & Jan Mikšovský

  3. Institute of Microbiology ASCR v.v.i., Vídeňská 1083, Prague 4, Czech Republic

    Marie Weiserová

  4. Lasak, Ltd., Papírenská 25, 160 00, Prague 6, Czech Republic

    Jakub Strnad

  5. Anton Paar GmbH, Graz, Austria

    Thomas Luxbacher

Authors
  1. Miroslav Jelínek
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  2. Tomáš Kocourek
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  3. Karel Jurek
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  4. Jan Remsa
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  5. Jan Mikšovský
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  6. Marie Weiserová
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  7. Jakub Strnad
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  8. Thomas Luxbacher
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Correspondence to Miroslav Jelínek.

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Jelínek, M., Kocourek, T., Jurek, K. et al. Antibacterial properties of Ag-doped hydroxyapatite layers prepared by PLD method. Appl. Phys. A 101, 615–620 (2010). https://doi.org/10.1007/s00339-010-5911-x

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  • DOI: https://doi.org/10.1007/s00339-010-5911-x

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