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Hepatitis B vaccination response of treatment-naive patients with juvenile idiopathic arthritis

  • Observational Research
  • Published:
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Abstract

To evaluate the vaccine response of treatment-naive juvenile idiopathic arthritis (JIA) patients who were fully vaccinated against Hepatitis B Virus (HBV) and then compare their antibody status with healthy controls. In this multicenter study, initial visit hepatitis B surface antigen (HbsAg) and anti-hepatitis B surface antibody (anti-Hbs) titers of 262 treatment-naive JIA patients who were followed up regularly between May 2015 and October 2019 were evaluated retrospectively from patients’ medical records and compared with 276 healthy peers. Both HbsAg and anti-Hbs antibody titers were tested by the ELISA technique. Anti-HBs titers ≥ 10 IU/L were considered as reactive indicating seroprotection against HBV. In the JIA group, seropositivity rate was 59.1% while 72.9% of the control group were immune against HBV (p = 0.002). The median titer for anti-Hbs was 14 (range: 0–1000) IU/L in the patient group and 43.3 (range: 0–1000) IU/L in the control group (p = 0.01). Neither JIA patients nor healthy controls were positive for HbsAg. Patients with JIA vaccinated according to the national vaccination schedule were evaluated at their first visit in pediatric rheumatology outpatient clinics for anti-Hbs presence and it was found that they have lesser seroprotectivity than their age and sex-matched routinely vaccinated, healthy peers. So, to complete missing vaccines and booster vaccine doses, assessing the immune status of the patients at the time of diagnosis against HBV should be in the check-list of physicians dealing with pediatric rheumatic diseases.

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The data underlying this article will be shared on reasonable request to the corresponding author.

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Funding

No specific funding was received from any bodies in the public, commercial or not-for-profit sectors to carry out the work described in this article.

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Authors and Affiliations

  1. Department of Pediatric Rheumatology, Istanbul University Medical School, Istanbul University Istanbul Faculty of Medicine, Fatih, Istanbul, Turkey

    Figen Çakmak, Fatma Gul Demirkan & Nuray Aktay Ayaz

  2. Department of Pediatric Rheumatology, Zeynep Kamil Women and Children’s Diseases Training and Research Hospital, University of Health Sciences, Istanbul, Turkey

    Mustafa Çakan

  3. Department of Pediatric Rheumatology, Umraniye Training and Research Hospital, University of Health Sciences, Istanbul, Turkey

    Ferhat Demir & Betül Sözeri

  4. Department of Pediatric Rheumatology, Kocaeli University School of Medicine, Kocaeli, Turkey

    Hafize Emine Sonmez

  5. Department of Urology, Haseki Training and Research Hospital, Istanbul, Turkey

    Sedat Çakmak

  6. Department of Pediatric Rheumatology, Bakirkoy Dr Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey

    Şerife Gül Karadağ

Authors
  1. Figen Çakmak
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  2. Mustafa Çakan
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  8. Nuray Aktay Ayaz
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Contributions

All authors whose names appear on the submission. (1) Made substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data; or the creation of new software used in the work; (2) drafted the work or revised it critically for important intellectual content; (3) approved the version to be published; and (4) agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

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Correspondence to Nuray Aktay Ayaz.

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Ethical approval

The study was conducted according to Good Clinical Practice guidelines and the Declaration of Helsinki, with necessary approvals from the local Ethical Committee (B.10.1.TKH.4.34.H.GP.0.01/353).

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Çakmak, F., Çakan, M., Demir, F. et al. Hepatitis B vaccination response of treatment-naive patients with juvenile idiopathic arthritis. Rheumatol Int 42, 1199–1205 (2022). https://doi.org/10.1007/s00296-021-04833-3

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  • DOI: https://doi.org/10.1007/s00296-021-04833-3

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