Skip to main content

Advertisement

SpringerLink
Log in

Trends in Hepatitis B and Hepatitis C Virus among Blood Donors over 16 Years in Turkey

  • Published:
European Journal of Epidemiology Aims and scope Submit manuscript

Abstract

Background: We document in the present study the trends over the sixteen years in HBV and HCV seroprevalence among blood donors in Turkish populations. Methods: In this study, serologic test results of whole blood (n = 6.240.130) donors at 22 Red Crescent Centers between 1989 and 2004 were evaluated retrospectively. Results and conclusion: The overall prevalence was 4.19% for HBsAg and 0.38% for HCV antibody during the study period. The annual prevalence of HBsAg gradually increased from 4.92% in 1989 to 5.23% in 1991 (p=0.001, t=21.00, CI95, 17237–22490) and gradually decreased from that to 2.10% in 2004 (p=0.001, t=17.27, CI95, 12869–21342). The seroprevalence of HCV antibody gradually increased from 18 per 10.000 in 1996, to 56 per 10.000 in 1998 (p=0.073, t=3.81, CI95, 459.62–5721.23), while that decreased to 34 per 10.000 in 2004 (p=0.021, t=7.49, CI95, 743.98–3980.11). The seroprevalence of hepatitis B and C has decreased markedly between 1989 and 2004 in Turkey. This could be related to the significant increase in the number of volunteer blood donors that increased from 135,779 to 197,815.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

CI:

Confidence interval

DBD:

Directed blood donors

ELISA:

Enzyme-linked immunosorbent assay

HBV:

Hepatitis B virus

HCV:

Hepatitis C virus

RIBA:

Recombinant immunoblood assay

RVD:

Regular voluntary donors

TTIs:

Transfusion transmitted infections

References

  1. LS Doll LR Petersen CR White JW, Ward (1991) ArticleTitleHIV Blood Donor Study Group. Human immunodeficiency virus type 1 infected blood donors: behavioral characteristics and reasons for donation Transfusion 31 704–709 Occurrence Handle10.1046/j.1537-2995.1991.31892023494.x Occurrence Handle1:STN:280:By2D38zkvFA%3D Occurrence Handle1926313

    Article  CAS  PubMed  Google Scholar 

  2. H Jager C Jersiid JC. Emmanuel (1991) ArticleTitleSafe blood transfusions in Africa AIDS 5 163–168

    Google Scholar 

  3. B Mutlu M Meric A Willke (2004) ArticleTitleSeroprevalence of hepatitis B and C Virus, human immunodeficiency virus and syphilis in the blood donors Mikrobiyol Bul 38 445–448 Occurrence Handle15700672

    PubMed  Google Scholar 

  4. N Kocak S Hepgul S Ozbayburtlu H Altunay MF Ozsoy E Kosan Y Aksu G Yilmaz A. Pahsa (2004) ArticleTitleTrends in major transfusion – transmissible infections among blood donors over 17 years in Istanbul, Turkey J Int Med Res 32 671–675 Occurrence Handle1:STN:280:DC%2BD2cnhsFWnsw%3D%3D Occurrence Handle15587762

    CAS  PubMed  Google Scholar 

  5. JD Allain A Kitchen S Aloysius et al. (1996) ArticleTitleSafety and efficacy of hepatitis C virus antibody screening of blood donors with two sequential screening assays Transfusion 36 401–405 Occurrence Handle10.1046/j.1537-2995.1996.36596338024.x Occurrence Handle1:STN:280:BymA3sfgt1A%3D Occurrence Handle8693503

    Article  CAS  PubMed  Google Scholar 

  6. DR Cox EJ Snell (Eds) (1989) Analysis of Binary Data Chapman & Hall London

    Google Scholar 

  7. F Sarkodie M Adarkwa Y Adu-Sarkodie D Candotti JW Acheampong JP Allain (2001) ArticleTitleScreening for viral markers in volunteer and replacement blood donors in West Africa Vox Sanguinis 80 142–147 Occurrence Handle10.1046/j.1423-0410.2001.00023.x Occurrence Handle1:STN:280:DC%2BD387gvVGrtw%3D%3D Occurrence Handle11840974

    Article  CAS  PubMed  Google Scholar 

  8. SA Glynn SH Kleinman GB Schreiber MP Busch et al. (2000) ArticleTitleTrends in incidence and prevalence of major transfusion-transmissible viral infection in US blood donors 1991–1996 JAMA 284 1–8 Occurrence Handle10.1001/jama.284.2.229

    Article  Google Scholar 

  9. D Voak EA Caffrey JA Barbara A Pollock M Scott MC. Contreras (1998) ArticleTitleAffordable safety for the blood supply in developed and developing countries Transfus Med 8 73–76 Occurrence Handle10.1046/j.1365-3148.1998.00146.x Occurrence Handle1:STN:280:DyaK1czktVCgsQ%3D%3D Occurrence Handle9675782

    Article  CAS  PubMed  Google Scholar 

  10. RY Dodd SL Stramer J Aberle-Grasse E. Notari (2000) ArticleTitleRisk of hepatitis and retroviral infections among blood donors and introduction of nucleic acid testing (NAT) Dev Biol 102 19–27 Occurrence Handle1:STN:280:DC%2BD3c3lt1Slsw%3D%3D

    CAS  Google Scholar 

  11. M Sunbul H. Leblebicioglu (2005) ArticleTitleDistribution of hepatitis B visur genotypes with chronic hepatitis B in Turkey World J Gastroenterol 11 1976–1980 Occurrence Handle1:CAS:528:DC%2BD2MXktFyru7c%3D Occurrence Handle15800989

    CAS  PubMed  Google Scholar 

  12. E Yildiz A Oztan F Sar F Pinarbasi R Cetin-Atalay H Akkiz M. Ozturk (2002) ArticleTitleMolecular characterization of a ful genome Turkish hepatitis C virus 1b isolate (HCV-TR1): a predominant viral form in Turkey Virus Genes 25 169–177 Occurrence Handle10.1023/A:1020161818764 Occurrence Handle1:CAS:528:DC%2BD38XovF2msrk%3D Occurrence Handle12416679

    Article  CAS  PubMed  Google Scholar 

  13. H Agırbaslı N Yalman O Devecioglu S Anak F Ridolfi H Bilgen G. Gedikoglu (1998) ArticleTitleHematoloji-Onkoloji hastalarının donorlerinde hepatit B, hepatit C, HIV ve VDRL taraması Viral Hepatit Derg 2 145–148

    Google Scholar 

  14. Yenen OS, Cavuslu S, Aksu Y, Kocak N, Ozsoy MF, Altunay HTen years (1987–1996) epidemiological trend of HIV, HBV and Syphilis among blood donors in Istanbul. 3rd Congress of Balkan Military Medical Committee, Athens-Greece, 1998 May 10–13

  15. CG Teo FG Gabriel PP. Mortimer (1992) ArticleTitleConfirmation of second generation anti-hepatitis C virus enzyme immunoassays by antigenic cross-validation J Clin Pathol 45 917–920 Occurrence Handle1:STN:280:ByyD2MrltVw%3D Occurrence Handle1331199

    CAS  PubMed  Google Scholar 

  16. J Pillonel N Le Marrec A Girault D David S. Laperche (2005) ArticleTitleEpidemiological surveillance of blood donors and residual risk of blood-borne infections in France, 2001 to 2003 Transfus Clin Biol 12 239–246 Occurrence Handle10.1016/j.tracli.2005.04.032 Occurrence Handle1:STN:280:DC%2BD2MzmslKktw%3D%3D Occurrence Handle15963749

    Article  CAS  PubMed  Google Scholar 

  17. M Gonzalez V Regine V Piccini F Vulcano A Giampaolo HJ. Hassan (2005) ArticleTitleResidual risk of transfusion-transmitted human immunodeficiency virus, hepatitis C virus, and hepatitis B virus infections in Italy Transfusion 45 1670–1675 Occurrence Handle10.1111/j.1537-2995.2005.00576.x Occurrence Handle16181219

    Article  PubMed  Google Scholar 

  18. http://www.saglik.gov.tr/extras/istatistikler/ger_bil_2001_ 1/t _13.htm

  19. R Franchis G Meucci M Vecchi et al. (1993) ArticleTitleThe natural history of asymptomatic hepatitis B surface antigen carriers Ann Intern Med 118 191–194 Occurrence Handle8417636

    PubMed  Google Scholar 

  20. CA Gogos KP Fouka G Nikiforidis K Avgeridis G Sakellaropoulos H Bassaris A Maniatis A. Skoutelis (2003) ArticleTitlePrevalence of hepatitis B and C virus infection in the general population and selected groups in South-Western Greece Eur J Epidemiol 18 551–557 Occurrence Handle10.1023/A:1024698715741 Occurrence Handle1:STN:280:DC%2BD3szntl2mtQ%3D%3D Occurrence Handle12908721

    Article  CAS  PubMed  Google Scholar 

  21. K Soldan K Davison B. Dow (2005) ArticleTitleEstimates of frequency of HBV, HCV, and HIV infections donations entering the blood supply in the United Kingdom, 1996 to 2003 Euro Surveill 10 17–19 Occurrence Handle1:STN:280:DC%2BD2MvmsVKjsQ%3D%3D Occurrence Handle15735312

    CAS  PubMed  Google Scholar 

  22. DN Mbanya D Takam PM. Ndumber (2003) ArticleTitleSerological findings amongst first-time blood donors in Yaounde, Cameroon: is safe donation a realtiy or a myth? Transfus Med. 13 267–273 Occurrence Handle10.1046/j.1365-3148.2003.00453.x Occurrence Handle1:STN:280:DC%2BD3srjvVantw%3D%3D Occurrence Handle14617337

    Article  CAS  PubMed  Google Scholar 

  23. MJ Alter EE Mast (1994) ArticleTitleThe epidemiology of viral hepatitis in the United States Gastroenterol Clin North Am 3 437–455

    Google Scholar 

  24. Balik I. Dunyada ve Turkiye’de hepatit-B epidemiyolojisi. In: Kılıcturgay K (eds), Viral Hepatit 92 Kitabi. Viral Hepatitle Savasım Dernegi, Istanbul 1992: 65–81

  25. O Uzun (2002) Viral Hepatitler: Epidemiyoloji O Uzun S Unal (Eds) Guncel Bilgiler Isiginda Inferiyon Hastatiklari Bilimsel Tıp Yayınevi Ankara 561–566

    Google Scholar 

  26. AK Gurbuz K Dogalp M. Gulsen (1993) ArticleTitleHepatit C virus infeksiyonunda aile ici gecis Gastroenteroloji 4 405–408

    Google Scholar 

  27. J Pillonel S. Laperche (2004) ArticleTitleGroupe “Agents Transmissibles par Transfusion” de la Societe francaise de transfusion sanguine; Etablissement francais du sang; Centre de transfusion sanguine des armies. Trends in residual risk of transfusion-transmitted viral infections (HIV, HCV, HBV) in France between 1992 and 2002 and impact of viral genome screening (Nucleic Acid Testing) Transfus Clin Biol 11 81–86 Occurrence Handle10.1016/j.tracli.2004.02.004 Occurrence Handle1:STN:280:DC%2BD2c3mtFGjuw%3D%3D Occurrence Handle15120104

    Article  CAS  PubMed  Google Scholar 

  28. MV Atanasova IA Haydouchka SP Zlatev YD Stolilova YT Iliev NG. Mateva (2004) ArticleTitlePrevalence of antibodies against hepatitis C virus and hepatitis B coinfection in healthy population in Bulgaria. A seroepidemiological study Minerva Gastroenterol Dietol 50 89–96 Occurrence Handle1:STN:280:DC%2BD2M%2FovVOjtQ%3D%3D Occurrence Handle15719010

    CAS  PubMed  Google Scholar 

  29. M. Contreras (1994) ArticleTitleIs the unpaid/paid donation debate for better or for worse? Advantages of unpaid donations Blood Coagul Fibrinolysis 5 IssueIDSuppl 27–28

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Turkish Red Crescent Center-Ankara, Turkey

    Emekdas Gurol, Artuk Cigdem & Aksoy Armagan

  2. Gulhane Military Medical Academy, Department of Infectious Diseases and Clinical Microbiology, Haydarpasa Training Hospital, Tibbiye Street, Uskudar, 34668, Istanbul, Turkey

    Cavuslu Saban & Oncul Oral

Authors
  1. Emekdas Gurol
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Cavuslu Saban
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Oncul Oral
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Artuk Cigdem
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Aksoy Armagan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Oncul Oral.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gurol, E., Saban, C., Oral, O. et al. Trends in Hepatitis B and Hepatitis C Virus among Blood Donors over 16 Years in Turkey. Eur J Epidemiol 21, 299–305 (2006). https://doi.org/10.1007/s10654-006-0001-2

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10654-006-0001-2

Keywords

Search

Navigation