Abstract
Statistical analysis plays a critical role in data interpretation in all fields and particularly so for clinical data where important treatment decisions are made. We provide here an in-depth and illustrative analysis to examine patterns and radiographic scores in an early disease rheumatoid arthritis cohort over a 3-year follow-up period. The total Sharp radiographic scores were interpolated from the rates at 6 months, 1, 2, and 3 years and were transformed to count data after rounding. The generalized estimating equations approach and two-part models were applied to analyze the longitudinal radiographic scores using the clinical, demographic, and therapeutic characteristics of the patients after adjusting for the pattern outcomes. Total Sharp scores were modeled, assuming that they were Poisson distributed or had a negative binomial distribution with either an AR(1) working correlation matrix or an exchangeable working correlation matrix. To account for the excessive zero counts, we used two-part models that include the zero-inflated Poisson and the zero-inflated negative binomial to fit the data. This is an innovation because two-part models have not been used in rheumatology even though they are highly appropriate for analyzing data from rheumatic studies. In addition, we analyzed data using generalized estimating equations and compared results from different models using formal statistical goodness-of-fit criteria and arrive at the best model for predicting purposes.
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Acknowledgments
We thank Professor Abdelmonem A. Afifi from UCLA’s Fielding School of Public Health Department of Biostatistics for his guidance on the analyses and Dr. John Sharp formerly from the University of Washington for contribution to this paper. We also thank the reviewers and editors for their suggestions and comments, which led to a much improved paper. Dr. Grace Park’s work was supported in part by the Doctoral Dissertation Award from The Arthritis Foundation while she was at UCLA. The Consortium of Practicing Rheumatologists was supported in part by NIH/NIAMS P60 AR 26834, Southern California Chapter of the Arthritis Foundation, Specialty Laboratories, and the Oregon Arthritis Foundation. Professor Wong was supported in part by a senior investigator award from the Scleroderma Foundation.
Conflict of interest
None from any author, as this was a product of research conducted for a dissertation while Dr. Park was at UCLA.
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This study was conducted for the Consortium of Practicing Rheumatologists.
The members of the Consortium of Practicing Rheumatologists are given in “Appendix.”
Appendix: Consortium of Practicing Rheumatologists
Appendix: Consortium of Practicing Rheumatologists
J. Javier Orozco-Alcala, MD (Guadalajara, MEXICO); Karen Basin, MD (Medford, OR, USA); Martin Berry, MD (Bakersfield, CA, USA); Charles Boniske, MD (Visalia, CA, USA); Melvin Britton, MD (Palo Alto, CA, USA); Ken Bulpitt, MD (Torrance, CA, USA); Jeffrey Carlin, MD (Seattle, WA, USA); H. Walter Emori, MD (Medford, OR, USA); Robert Ettlinger, MD (Tacoma, WA, USA); Daniel Furst, MD (Los Angeles, CA, USA); Gregory Gardner, MD (Seattle, WA, USA); Robert Gerber, MD (Medford, OR, USA); Maria Greenwald, MD (Palm Desert, CA, USA); Karen Kolba, MD (Santa Maria, CA, USA; George Krick, MD (Tacoma, WA, USA); Max Lundberg, MD (Sandy, UT, USA); Anne MacGuire, MD (Casper, WY, USA); Philip Mease, MD (Seattle, WA, USA); Ghislaine Bernard Medina, MD (Guadalajara, MEXICO); Raymond Mirise, MD (Glendale, AZ, USA); Ina Oppliger, MD (Kansas City, MO, USA); Allen Sawitzke, MD (Salt Lake City, UT, USA); Gerald Schoepflin, MD (Portland, OR, USA); John Seaman, MD (Tacoma, WA, USA); Robert Shapiro, MD (Sacramento, CA, USA); Fredrica Smith, MD (Los Alamos, CA, USA); Marcia Sparling, MD (Vancouver, WA, USA); Elizabeth Tindall, MD (Portland, OR, USA); Michael Weisman, MD (Los Angeles, CA, USA); Mark Wener, MD (Seattle, WA, USA); Craig Wiesenhutter, MD (Coeur d’Alene, ID, USA); Kenneth Wiesner, MD (Sacramento, CA, USA); Robert Willkens, MD (Seattle, WA, USA); Kenneth Wilske, MD (Seattle, WA, USA); Andrew Wong, MD (Northridge, CA, USA); George Young, MD (Boulder, CO, USA).
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Park, G.S., Wong, W.K., Khanna, D. et al. Examining radiographic outcomes over time. Rheumatol Int 34, 271–279 (2014). https://doi.org/10.1007/s00296-013-2879-9
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DOI: https://doi.org/10.1007/s00296-013-2879-9