Abstract
In this study, novel PVA/Fe3O4@SiO2@CPS@SID@Ni magnetic fibrous composite polymer (PVA/MFCP nanostructures) according to the electrospinning method was synthesized. The structure of PVA/MFCP nanostructures by Scanning Electron Microscopy, Fourier Transform Infrared spectroscopy, X-Ray Diffraction, Vibrating Sample Magnetometer, N2 adsorption/desorption isotherms and thermal behavior were characterized. Results of the structure investigation showed that the synthesized compound was in the form of nanofibers with magnetic properties and high specific surface area. Anti-cancer properties of synthetic PVA/Fe3O4@SiO2@CPS@SID@Ni (MFCP) were evaluated by the MTT method on MCF-7 breast cancer cells, and IC50 119 μg/ml was observed at 48 h. Antibacterial and antifungal properties of the synthesized PVA/MFCP nanostructures based on Minimum Inhibitory Concentration, Minimum Bactericidal Concentration (MBC), and Minimum Fungicidal Concentration were tested. The MBC values for PVA/MFCP, between 8 and 256 μg/ml were obtained. The results proved that the biological activity of PVA/MFCP nanostructures in some cases, has a better effect than commercial drugs.
Similar content being viewed by others
References
Shiri L, Heidari L, Kazemi M (2018) Magnetic Fe3O4 nanoparticles supported imine/Thiophene-nickel (II) complex: A new and highly active heterogeneous catalyst for the synthesis of polyhydroquinolines and 2, 3-dihydroquinazoline-4 (1H)-ones. Appl Organomet Chem 32(1):e3943
Sajjadifar S, Gheisarzadeh Z (2019) Isatin-SO3H coated on amino propyl modified magnetic nanoparticles (Fe3O4@ APTES@ isatin-SO3H) as a recyclable magnetic nanoparticle for the simple and rapid synthesis of pyrano [2, 3-d] pyrimidines derivatives. Appl Organomet Chem 33(1):e4602
Tamoradi T, Ghadermazi M, Ghorbani-Choghamarani A (2018) Ni (II)-Adenine complex coated Fe3O4 nanoparticles as high reusable nanocatalyst for the synthesis of polyhydroquinoline derivatives and oxidation reactions. Appl Organomet Chem 32(1):e3974
Zolfigol MA, Safaiee M, Bahrami-Nejad N (2016) Dendrimeric magnetic nanoparticle cores with Co-phthalocyanine tags and their application in the synthesis of tetrahydrobenzo [b] pyran derivatives. New J Chem 40(6):5071–5079
Hosseinzadegan S, Hazeri N, Maghsoodlou MT (2020) Synthesis of novel thiazolo [3, 2-a] chromeno [4, 3-d] pyrimidine-6 (7H)-ones by bioactive Fe3O4@ gly@ thiophen@ Cu (NO3) 2 as reusable magnetic nanocatalyst. Appl Organomet Chem 34(9):e5797
Mousavifar SM, Kefayati H, Shariati S (2018) Fe3O4@ Propylsilane@ Histidine [HSO4-] magnetic nanocatalysts: Synthesis, characterization and catalytic application for highly efficient synthesis of xanthene derivatives. Appl Organomet Chem 32(4):e4242
Zaoui F, Sebba FZ, Liras M, Sebti H, Hachemaoui M, Mokhtar A, Beldjilali M, Bounaceur B, Boukoussa B (2021) Ultrasonic preparation of a new composite poly (GMA)@ Ru/TiO2@ Fe3O4: application in the catalytic reduction of organic pollutants. Mater Chem Phys 260:124146
Hachemaoui M, Mokhtar A, Mekki A, Zaoui F, Abdelkrim S, Hacini S, Boukoussa B (2020) Composites beads based on Fe3O4@ MCM-41 and calcium alginate for enhanced catalytic reduction of organic dyes. Int J Biol Macromol 164:468–479
Hachemaoui M, Mokhtar A, Abdelkrim S, Ouargli-Saker R, Zaoui F, Hamacha R, Habib Zahmani H, Hacini S, Bengueddach A, Boukoussa B (2021) Improved catalytic activity of composite beads calcium alginate@ MIL-101@ Fe3O4 towards reduction toxic organic dyes. J Polym Environ 29(12):3813–3826
Hosseinzadegan S, Hazeri N, Maghsoodlou MT, Moghaddam-Manesh M, Shirzaei M (2020) Synthesis and evaluation of biological activity of novel chromeno [4, 3-b] quinolin-6-one derivatives by SO 3 H-tryptamine supported on Fe 3 O 4@ SiO 2@ CPS as recyclable and bioactive magnetic nanocatalyst. J Iran Chem Soc 17(12):3271–3284
Sun L-L, Li Y-H, Shi H (2019) A ketone functionalized Gd (III)-MOF with low cytotoxicity for anti-cancer drug delivery and inhibiting human liver cancer cells. J Cluster Sci 30(1):251–258
Pooresmaeil M, Namazi H (2020) Facile preparation of pH-sensitive chitosan microspheres for delivery of curcumin; characterization, drug release kinetics and evaluation of anticancer activity. Int J Biol Macromol 162:501–511
Kamel A, Saleh M (2000) Recent studies on the chemistry and biological activities of the organosulfur compounds of garlic (Allium sativum). Stud Nat Prod Chem 23:455–485
Zentz F, Labia R, Sirot D, Faure O, Grillot R, Valla A (2005) Syntheses, in vitro antibacterial and antifungal activities of a series of N-alkyl, 1, 4-dithiines. Il Farmaco 60(11–12):944–947
Bielenica A, Kossakowski J, Struga M, Dybała I, La Colla P, Tamburini E, Loddo R (2011) Biological evaluation of novel 1, 4-dithiine derivatives as potential antimicrobial agents. Med Chem Res 20(8):1411–1420
Block E, Ahmad S, Jain MK, Crecely RW, Apitz-Castro R, Cruz MR (1984) The chemistry of alkyl thiosulfate esters. 8.(E, Z)-Ajoene: a potent antithrombotic agent from garlic. J Am Chem Soc 106(26):8295–8296
Apitz-Cȧstro R, Cabrera S, Cruz M, Ledezma E, Jain M (1983) Effects of garlic extract and of three pure components isolated from it on human platelet aggregation, arachidonate metabolism, release reaction and platelet ultrastructure. Thromb Res 32(2):155–169
Moghaddam-Manesh M, Sheikhhosseini E, Ghazanfari D, Akhgar M (2020) Synthesis of novel 2-oxospiro [indoline-3, 4′-[1, 3] dithiine]-5′-carbonitrile derivatives by new spiro [indoline-3, 4′-[1, 3] dithiine]@ Cu (NO3) 2 supported on Fe3O4@ gly@ CE MNPs as efficient catalyst and evaluation of biological activity. Bioorg Chem 98:103751
Moghaddam-Manesh M, Ghazanfari D, Sheikhhosseini E, Akhgar M (2020) Synthesis of bioactive magnetic nanoparticles spiro [indoline-3, 4′-[1, 3] dithiine]@ Ni (NO3) 2 supported on Fe3O4@ SiO2@ CPS as reusable nanocatalyst for the synthesis of functionalized 3, 4-dihydro-2H-pyran. Appl Organomet Chem 34(4):e5543
Roohani M, Shabanian M, Kord B, Hajibeygi M, Khonakdar HA (2016) New functional Fe3O4 nanoparticles utilizing as adjuvant in the green PVA/cellulose whiskers nanocomposite. Thermochim Acta 635:17–25
Irvin CW, Satam CC, Meredith JC, Shofner ML (2019) Mechanical reinforcement and thermal properties of PVA tricomponent nanocomposites with chitin nanofibers and cellulose nanocrystals. Compos A Appl Sci Manuf 116:147–157
Sridhar R, Venugopal J, Sundarrajan S, Ravichandran R, Ramalingam B, Ramakrishna S (2011) Electrospun nanofibers for pharmaceutical and medical applications. Journal of drug delivery science and technology 21(6):451–468
Eghbalifam N, Shojaosadati SA, Hashemi-Najafabadi S, Khorasani AC (2020) Synthesis and characterization of antimicrobial wound dressing material based on silver nanoparticles loaded gum Arabic nanofibers. Int J Biol Macromol 155:119–130
Mahmud MM, Zaman S, Perveen A, Jahan RA, Islam MF, Arafat MT (2020) Controlled release of curcumin from electrospun fiber mats with antibacterial activity. J Drug Delivery Sci Technol 55:101386
Zhang W, Ronca S, Mele E (2017) Electrospun nanofibres containing antimicrobial plant extracts. Nanomaterials 7(2):42
Sargazi G, Ebrahimi AK, Afzali D, Badoei-dalfard A, Malekabadi S, Karami Z (2019) Fabrication of PVA/ZnO fibrous composite polymer as a novel sorbent for arsenic removal: design and a systematic study. Polym Bull 76(11):5661–5682
Azizabadi O, Akbarzadeh F, Sargazi G, Chauhan NPS (2021) Preparation of a novel ti-metal organic framework porous nanofiber polymer as an efficient dental nano-coating: physicochemical and mechanical properties. Polym Plast Technol Mater 60(7):734–743
Moghaddam‐Manesh M, Hosseinzadegan S (2021) Introducing new method for the synthesis of polycyclic compounds containing [1, 3] dithiine derivatives, with anticancer and antibacterial activities against common bacterial strains between aquatic and human. J Heterocyclic Chem
Zeraati M, Moghaddam-Manesh M, Khodamoradi S, Hosseinzadegan S, Golpayegani A, Chauhan NPS, Sargazi G (2022) Ultrasonic assisted reverse micelle synthesis of a novel Zn-metal organic framework as an efficient candidate for antimicrobial activities. J Mol Struct 1247:131315
Wang D, Han D, Shi Z, Wang J, Yang J, Li X, Song H (2018) Optimized design of three-dimensional multi-shell Fe3O4/SiO2/ZnO/ZnSe microspheres with type II heterostructure for photocatalytic applications. Appl Catal B 227:61–69
Sargazi G, Afzali D, Mostafavi A, Kazemian H (2020) A novel composite derived from a metal organic framework immobilized within electrospun nanofibrous polymers: An efficient methane adsorbent. Appl Organomet Chem 34(3):e5448
Kaykhaii M, Hashemi SH, Andarz F, Piri A, Sargazi G, Boczkaj G (2021) Chromium-based metal organic framework for pipette tip micro-solid phase extraction: an effective approach for determination of methyl and propyl parabens in wastewater and shampoo samples. BMC chemistry 15(1):1–12
Deng H, Kang S, Wang C, He H, Zhang C (2018) Palladium supported on low-surface-area fiber-based materials for catalytic oxidation of volatile organic compounds. Chem Eng J 348:361–369
Abbas S, Lee H, Hwang J, Mehmood A, Shin H-J, Mehboob S, Lee J-Y, Ha HY (2018) A novel approach for forming carbon nanorods on the surface of carbon felt electrode by catalytic etching for high-performance vanadium redox flow battery. Carbon 128:31–37
Funding
Authors are required to disclose financial or non-financial interests that are directly or indirectly related to the work submitted for publication.
Author information
Authors and Affiliations
Corresponding author
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Moghaddam-manesh, M., Sargazi, G., Roohani, M. et al. Synthesis of PVA/Fe3O4@SiO2@CPS@SID@Ni as novel magnetic fibrous composite polymer nanostructures and evaluation of anti-cancer and antimicrobial activity. Polym. Bull. 80, 11919–11930 (2023). https://doi.org/10.1007/s00289-022-04584-6
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00289-022-04584-6