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Biological evaluation of novel 1,4-dithiine derivatives as potential antimicrobial agents

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Abstract

The preparation of twelve aminoalkanol derivatives of 2,3-dihydro-5H-[1,4]dithiino[2,3-c]pyrrole-5,7(6H)-dione was described. Newly obtained compounds, as well as their propyl and butyl analogues, were evaluated in vitro against selected viruses. Selected derivatives were tested for their antibacterial and antifungal activity. Compounds 3h, 3j, 4b and 5a–d showed moderate to significant protections against CVB-2, HSV-1 and YFV viruses. The molecular structures of 4a, 5c and 5g were determined by an X-ray analysis.

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Authors and Affiliations

  1. Department of Medical Chemistry, The Medical University of Warsaw, 3 Oczki Street, 02-007, Warsaw, Poland

    Anna Bielenica, Jerzy Kossakowski & Marta Struga

  2. Faculty of Chemistry, Maria Curie-Sklodowska University, 20-031, Lublin, Poland

    Izabela Dybała

  3. Department of Biomedical Science and Technology, University of Cagliari, Cittadella Universitaria, 09042, Monserrato, Cagliari, Italy

    Paolo La Colla, Elena Tamburini & Roberta Loddo

Authors
  1. Anna Bielenica
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  2. Jerzy Kossakowski
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  3. Marta Struga
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  4. Izabela Dybała
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  5. Paolo La Colla
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  6. Elena Tamburini
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  7. Roberta Loddo
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Correspondence to Anna Bielenica.

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Bielenica, A., Kossakowski, J., Struga, M. et al. Biological evaluation of novel 1,4-dithiine derivatives as potential antimicrobial agents. Med Chem Res 20, 1411–1420 (2011). https://doi.org/10.1007/s00044-010-9513-0

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  • DOI: https://doi.org/10.1007/s00044-010-9513-0

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