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Crude dry extract from Colocasia esculenta in association with poly(vinyl alcohol) as biomaterial to prepare bioactive wound dressing

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Abstract

Colocasia esculenta (taro) is traditionally reported to be rich in bioactive compounds with pharmacological properties, and it is a source of starch—a natural polymer with film-forming capacity. The present work aimed to use the crude dry extract from taro rhizome in high proportions to form polymeric films in association with PVA, for use as biomaterials to prepare wound dressing. The films prepared by solvent casting technique were analyzed to evaluate their physicochemical parameters, barrier, and mechanical properties, and in vitro biocompatibility, important attributes for the functionality and safety of films for wound dressing application. The starch contained in the taro extract showed good filmogenic properties after prior gelatinization in water and then blending with the PVA solution containing glycerol. Moreover, the films obtained were thin, smooth, transparent, shiny, and domain-free. SEM photomicrographs showed the existence of a continuous and homogeneous microstructure. Additionally, the blends were partially miscible and presented an altered crystalline structure. The thermal stability and mechanical resistance parameters were improved due to the presence of the taro extract. In addition, the parameters pertaining to the functionality of the films as wound dressings were improved, particularly in the films containing higher proportions of the extract, which is configured as an advantage, since the taro extract proved to be non-cytotoxic, biocompatible, with healing activity, and it comes from a renewable source. Crude extract from taro rhizome blended with PVA proved to be suitable for the intended purpose.

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Acknowledgements

The authors are thankful to LUCCAR (Laboratório de Ultraestrutura Celular Carlos Alberto Redins da UFES—Edital MCT/FINEP/CT-INFRA-PROINFA 01/2006) by SEM analysis. Graphical abstract was made in part using BioRender.

Funding

This work was supported by the FAPES (Fundação de Amparo à Pesquisa e Inovação do Espírito Santo, Brazil) under Grant Number 201/2019; by CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil) under finance code 001; and by CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico—Brazil) with scholarships.

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  1. Programa de Pós-graduação em Ciências Veterinárias, Universidade Federal do Espírito Santo - UFES, Alegre, 29500-000, Brazil

    Elisabeth Maria López de Prado & Janaina Cecília Oliveira Villanova

  2. Laboratório de Desenvolvimento de Produtos Farmacêuticos - LDPF, Universidade Federal do Espírito Santo - UFES, Av. Alto Universitário, sem número, Guararema, Alegre, 29500-000, Brazil

    Geanne Aparecida de Paula, Fabiana Dayse Magalhães Siman, Eduardo Frizzera Meira, Juliana Aparecida Severi & Janaina Cecília Oliveira Villanova

  3. Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Federal do Espírito Santo - UFES, Vitória, 9043-900, Brazil

    Jessyca Aparecida Paes Dutra, Rodrigo Rezende Kitagawa & Janaina Cecília Oliveira Villanova

  4. Laboratório de Materiais Carbonosos e Cerâmicos - LMC, Universidade Federal do Espírito Santo - UFES, Vitória, 9043-900, Brazil

    Daniel Fernandes Cipriano & Jair Carlos Checon de Freitas

  5. Laboratório de Engenharia de Polímeros e Compósitos - LEPCom, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, 31270-901, Brazil

    Rodrigo Lamberti Oréfice

  6. Departamento de Engenharia Rural, Universidade Federal do Espírito Santo – UFES, Alegre, 29500-000, Brazil

    Lílian Gasparelli Carreira

Authors
  1. Elisabeth Maria López de Prado
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  2. Geanne Aparecida de Paula
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  3. Jessyca Aparecida Paes Dutra
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  4. Daniel Fernandes Cipriano
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  5. Rodrigo Rezende Kitagawa
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  6. Fabiana Dayse Magalhães Siman
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  7. Eduardo Frizzera Meira
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  8. Jair Carlos Checon de Freitas
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  9. Juliana Aparecida Severi
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  10. Lílian Gasparelli Carreira
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  11. Rodrigo Lamberti Oréfice
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  12. Janaina Cecília Oliveira Villanova
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Contributions

All authors contributed to the study's conception and design. Material preparation, data collection, and analysis were performed by EMLP, GAP, JAPD, and DFC. The first draft of the manuscript was written by EMLP. Other authors supervised the work and corrected previous versions of the manuscript. All authors commented on previous versions and approved the final version of the manuscript.

Corresponding author

Correspondence to Janaina Cecília Oliveira Villanova.

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Ethical approval

Ethics Committee on the Use of Animals (ECUA-UFES): approval number 006/2019.

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de Prado, E.M.L., de Paula, G.A., Dutra, J.A.P. et al. Crude dry extract from Colocasia esculenta in association with poly(vinyl alcohol) as biomaterial to prepare bioactive wound dressing. Polym. Bull. 80, 4783–4812 (2023). https://doi.org/10.1007/s00289-022-04263-6

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  • DOI: https://doi.org/10.1007/s00289-022-04263-6

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