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Exfoliation and gelation in laponite–carboxymethyl cellulose complexes and its application in sustained drug release

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Abstract

Herein, we have reported the exfoliation of laponite (L) in the presence of carboxymethyl cellulose (CMC) and the formation of CMC–laponite (CMC–L) nanocomposite gel. Analysis of CMC–L complex using XRD confirmed that the addition of CMC actually exfoliates laponites. The interplanar spacing of laponite was observed to increase from 0.74 to 0.98 nm when concentration of CMC, CCMC, increased from 0 to 0.5% w/v in aqueous solution of laponite having concentration of laponite, CL = 1% w/v. Time-dependent scattering intensity studied by dynamic light scattering on CMC–L complex (CCMC = 0.5% w/v, CL = 1% w/v) in aqueous medium illustrated that the exfoliation progresses with the passage of time. It was further observed that the CMC–L complex (CL = 1% w/v, CCMC ≥ 0.5% w/v) forms gel, and the strength of gel increases with the increase in CMC concentration in aqueous medium owing to interaction between exfoliated laponite and CMC. Furthermore, microstructure of the gels and their mesh size were studied using small-angle neutron scattering (SANS). SANS study revealed the fact that with the increase in CCMC from 0.5 to 2% w/v in CMC–L gels, mesh size, ξ decreases from 0.29 to 0.24 nm. This decrease in mesh size is responsible for sustained drug release of methylene blue which was chosen as a cationic model drug. The obtained drug release profile was fitted with different release kinetic models, and it was found that release profile follow first-order kinetic model.

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Acknowledgements

Authors are thankful to UGC start-up Grant (F.30-359/2017(BSR)) for the funding. Authors are also thankful to the Central Instrumentation Facility, Jamia Millia Islamia and Centre for Nanoscience and Nanotechnology, Jamia Millia Islamia for the instrumentation facility.

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Authors and Affiliations

  1. Soft Condense Matter Laboratory, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India

    Preeti Tiwari & Najmul Arfin

  2. School of Physical Sciences, Jawaharlal Nehru University, New Delhi, 110067, India

    Rahul Ranjan, Kishan Das & Himadri Bohidar

  3. Solid State Physics Division, Bhabha Atomic Research Centre, Mumbai, 400085, India

    V. K. Aswal

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  1. Preeti Tiwari
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Tiwari, P., Ranjan, R., Das, K. et al. Exfoliation and gelation in laponite–carboxymethyl cellulose complexes and its application in sustained drug release. Polym. Bull. 77, 5389–5406 (2020). https://doi.org/10.1007/s00289-019-03019-z

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