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Biosynthesis and Gene Regulation of Rhamnolipid Congeners

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Abstract

Rhamnolipid congeners have been widely used in agriculture and biomedicine as potent surfactants. They have recently attracted attention due to their diverse and versatile biological functions, which include an important bacterial virulence factor that makes them attractive targets for research into biosynthetic pathways and gene regulation. The intricate gene expression and regulation network controlling their biosynthesis remain to be completely understood. This article summarizes current knowledge about the biosynthesis pathways and regulatory mechanisms of rhamnolipid congeners, that meet the pharmacological needs of human health and agriculture.

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Funding

The project was supported by Natural Foundation of Zhejiang Province (LGF21H300003), Key Laboratory of Tropical Marine Ecosystem and Bioresource, MNR (2021QN03), National Natural Science Foundation of China (No. 42276137).

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Authors and Affiliations

  1. College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals & Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education & Key Laboratory, Pharmaceutical Engineering of Zhejiang Province, Zhejiang University of Technology, Hangzhou, China

    Jianwei Chen, Xiaoya Yu, Xingyue Lu, Wei Wang, Jiangwei Pan, Bin Wei, Huawei Zhang & Hong Wang

  2. Laboratory of Tropical Marine Ecosystem and Bioresource, Fourth Institute of Oceanography, Ministry of Natural Resources, Beihai, China

    Qunjian Yin

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Correspondence to Jianwei Chen or Hong Wang.

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Chen, J., Yu, X., Lu, X. et al. Biosynthesis and Gene Regulation of Rhamnolipid Congeners. Curr Microbiol 80, 302 (2023). https://doi.org/10.1007/s00284-023-03405-x

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