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The Role of Adhesion in Helicobacter pylori Persistent Colonization

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Abstract

Helicobacter pylori (H. pylori) has coevolved with its human host for more than 100 000 years. It can safely colonize around the epithelium of gastric glands via their specific microstructures and proteins. Unless patients receive eradication treatment, H. pylori infection is always lifelong. However, few studies have discussed the reasons. This review will focus on the adhesion of H. pylori from the oral cavity to gastric mucosa and summarize the possible binding and translocation characteristics. Adhesion is the first step for persistent colonization after the directional motility, and factors related to adhesion are necessary. Outer membrane proteins, such as the blood group antigen binding adhesin (BabA) and the sialic acid binding adhesin (SabA), play pivotal roles in binding to human mucins and cellular surfaces. And this may offer different perspectives on eradication.

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Abbreviations

(BabA):

Blood group antigen binding adhesin

(CAG):

Chronic atrophic gastritis

(GIT):

Gastrointestinal tract

(GSCs):

Gastric stem cells

(IFNs):

Interferons

(IM):

Intestinal metaplasia

(ILs):

Interleukins

(LP):

Lamina propria

(MNCs):

Mucous neck cells

(MM):

Muscularis mucosa

(NAG):

Non-atrophic gastritis

(NF-κB):

Nuclear factor-κB

(PCs):

Parietal cells

(SabA):

Salic acid binding adhesin

(sLe):

Sialyl-Lewis

(SPEM):

Spasmolytic polypeptide-expressing metaplasia

(SM):

Submucosa

(SMCs):

Surface mucous cells

(TNF):

Tumour necrosis factor

(ZCs):

Zymogenic cells

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Funding

This work was supported by Natural Science Foundation of Sichuan Province (2022NSFSC0819).

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  1. Hang Yang, Lixia Wang and Miao Zhang have contributed equally to this work.

Authors and Affiliations

  1. Department of Gastroenterology, West China Hospital, Sichuan University, No.37, Guo Xue Alley, Wu Hou District, Chengdu City, 610041, Sichuan Province, China

    Hang Yang, Miao Zhang & Bing Hu

  2. The Second Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China

    Lixia Wang

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  1. Hang Yang
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HY wrote the main manuscript and prepared Fig. 1–3. LW revised the manuscript and prepared Fig. 1. MZ revised the manuscript and prepared Fig. 2. BH designed and revised the manuscript. All authors reviewed the manuscript.

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Yang, H., Wang, L., Zhang, M. et al. The Role of Adhesion in Helicobacter pylori Persistent Colonization. Curr Microbiol 80, 185 (2023). https://doi.org/10.1007/s00284-023-03264-6

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