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Periodontal disease and Helicobacter pylori infection in oral cavity: a meta-analysis of 2727 participants mainly based on Asian studies

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Abstract

Objectives

To assess the association between periodontal disease and Helicobacter pylori (H. pylori) infection in oral cavity.

Materials and methods

We searched PubMed, Embase, Web of Science, Cochrane library, Gray literature, and clinicaltrials.gov for eligible studies up to September 25, 2019. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. The random-effects model was used with the software STATA 13.0. The Newcastle-Ottawa-Scale was used for quality evaluation.

Results

Twelve observational studies (eight from Asia, one from Europe, and three from the South America) involving 2727 participants were included in the meta-analysis. The overall pooled results showed that H. pylori infection in oral cavity was associated with periodontal disease (OR 2.53, 95% CI 1.86–3.44, P < 0.05). No significant heterogeneity among the articles was observed (I2 = 44.3%, P < 0.05). The sensitivity analysis indicated that the result of our meta-analysis was generally stable. The Begg test and the Egger test both showed no publication bias was observed (P = 0.45 and P = 0.18 respectively).

Conclusions

Based on current available evidence, it seemed there was a correlation between oral H. pylori infection and the occurrence of periodontal disease. However, since most of the data comes from Asia, more large-scale investigations with high quality from all over the world are needed to confirm the association.

Clinical relevance

H. pylori infection in oral may have a positive association with the prevalence of periodontal disease mainly in Asian populations.

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Funding

This study was supported by grants from Provincial Natural Science Foundation of Liaoning, China (201800506).

Author information

Authors and Affiliations

  1. Department of Periodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping District, Nanjing North Street No.117, Shenyang, 110002, China

    Yanqing Liu, Rong Li, Tong Xu, Yuxiao Luo & Qin Dong

  2. Department of Oromaxillofacial-Head and Neck Surgery, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping District, Nanjing North Street No.117, Shenyang, 110002, China

    Xiaomeng Xue

  3. Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping Distrct, Nanjing North Street No.117, Shenyang, 110002, China

    Xiaomeng Xue

  4. Department of Periodontics and Oral Biology, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping Distrct, Nanjing North Street No.117, Shenyang, 110002, China

    Junchao Liu, Jingbo Liu, Yaping Pan & Dongmei Zhang

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  1. Yanqing Liu
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  2. Rong Li
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  3. Xiaomeng Xue
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Contributions

Yanqing Liu and Rong Li contributed to the study selection and drafting the article. Yuxiao Luo and Qin Dong identified eligible studies for possible inclusion in the meta-analysis. Xiaomeng Xue and Tong Xu contributed to the data extraction. Junchao Liu and Jingbo Liu contributed to the literature quality assessment. Yaping Pan and Dongmei Zhang contributed to resolving disagreements and critically revising the manuscript. All authors have read and approved the final article.

Corresponding author

Correspondence to Dongmei Zhang.

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Liu, Y., Li, R., Xue, X. et al. Periodontal disease and Helicobacter pylori infection in oral cavity: a meta-analysis of 2727 participants mainly based on Asian studies. Clin Oral Invest 24, 2175–2188 (2020). https://doi.org/10.1007/s00784-020-03330-4

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