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Combined Therapies for the Treatment of Technically Unresectable Liver Malignancies: Bland Embolization and Radiofrequency Thermal Ablation within the Same Session

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Abstract

Purpose

This retrospective study evaluated the feasibility, efficacy, and safety of combining transcatheter arterial embolization (TAE) with radiofrequency thermal ablation (RFA) in a single session for the treatment of technically unresectable liver-only malignancies.

Methods

From May 2006 to January 2011, a total of 30 patients affected by liver metastases with single or multiple unresectable liver-only lesions underwent a combined treatment with TAE followed by RFA in the same session, for a total of 36 treated lesions. Patients were extrapolated from a cohort of patients discussed within the weekly institutional tumor board. TAE was performed by using 100 μm microspheres; RFA was performed immediately after TAE by positioning the electrode needle via ultrasound and/or computed tomographic guidance. Local tumor responses and procedure-related complications were evaluated.

Results

Completion of both procedures was obtained in all patients for all 36 lesions. Liver lesions had a maximum axial diameter ranging 16–59 mm. Postintervention unenhanced ablated areas ranged 28–104 mm in maximum axial diameter. Safety margins ranged 1–30.5 mm. Complete response, defined as complete devascularization at computed tomography, was obtained in all treated lesions for a maximum period of 12 months. Tumor relapse was observed in one patient at 12 months. Sixteen patients developed new liver lesions or progressive systemic disease during follow-up. Nine patients were still disease-free. Seven patients died as a result of systemic progressive disease. One major treatment-related complication was observed.

Conclusions

In patients with technically unresectable liver-only malignancies, single-session combined TAE-RFA is an effective and safe treatment.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Unit of Interventional Radiology, European Institute of Oncology, Via Ripamonti 435, 2041, Milan, Italy

    Guido Bonomo, Paolo Della Vigna, Lorenzo Monfardini, Gianluigi Orgera & Franco Orsi

  2. Unit of Biliopancreatic Surgery, European Institute of Oncology, Via Ripamonti 435, 2041, Milan, Italy

    Antonio Chiappa

  3. University of Milan, Milan, Italy

    Antonio Chiappa

  4. Unit of Minimally-Invasive Surgery, European Institute of Oncology, Via Ripamonti 435, 2041, Milan, Italy

    Paolo Pietro Bianchi

  5. Division of Medical Oncology, European Institute of Oncology, Via Ripamonti 435, 2041, Milan, Italy

    Maria Giulia Zampino

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  1. Guido Bonomo
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  2. Paolo Della Vigna
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  3. Lorenzo Monfardini
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  4. Gianluigi Orgera
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  8. Franco Orsi
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Correspondence to Guido Bonomo.

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Bonomo, G., Della Vigna, P., Monfardini, L. et al. Combined Therapies for the Treatment of Technically Unresectable Liver Malignancies: Bland Embolization and Radiofrequency Thermal Ablation within the Same Session. Cardiovasc Intervent Radiol 35, 1372–1379 (2012). https://doi.org/10.1007/s00270-012-0341-0

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  • DOI: https://doi.org/10.1007/s00270-012-0341-0

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