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Percutaneous Palliation of Pancreatic Head Cancer: Randomized Comparison of ePTFE/FEP–Covered Versus Uncovered Nitinol Biliary Stents

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Abstract

The purpose of this study was to compare the clinical effectiveness of expanded polytetrafluoroethylene/fluorinated-ethylene-propylene (ePTFE/FEP)–covered stents with that of uncovered nitinol stents for the palliation of malignant jaundice caused by inoperable pancreatic head cancer. Eighty patients were enrolled in a prospective randomized study. Bare nitinol stents were used in half of the patients, and ePTFE/FEP–covered stents were used in the remaining patients. Patency, survival, complications, and mean cost were calculated in both groups. Mean patency was 166.0 ± 13.11 days for the bare-stent group and 234.0 ± 20.87 days for the covered-stent group (p = 0.007). Primary patency rates at 3, 6, and 12 months were 77.5, 69.8, and 69.8% for the bare-stent group and 97.5, 92.2, and 87.6% for the covered-stent group, respectively. Mean secondary patency was 123.7 ± 22.5 days for the bare-stent group and 130.3 ± 21.4 days for the covered-stent group. Tumour ingrowth occurred exclusively in the bare-stent group in 27.5% of cases (p = 0.002). Median survival was 203.2 ± 11.8 days for the bare-stent group and 247.0 ± 20 days for the covered-stent group (p = 0.06). Complications and mean cost were similar in both groups. Regarding primary patency and ingrowth rate, ePTFE/FEP–covered stents have shown to be significantly superior to bare nitinol stents for the palliation of malignant jaundice caused by inoperable pancreatic head cancer and pose comparable cost and complications. Use of a covered stent does not significantly influence overall survival rate; nevertheless, the covered endoprosthesis seems to offer result in fewer reinterventions and better quality of patient life.

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Authors and Affiliations

  1. Department of Radiology, Guy’s and St. Thomas’ Hospitals, 1st Floor Lambeth Wing, Lambeth Palace Road, London, SE1 7EH, UK

    Miltiadis Krokidis

  2. Department of Radiological Sciences, “La Sapienza” University of Rome, Rome, Italy

    Fabrizio Fanelli, Mario Bezzi & Roberto Pasariello

  3. Unit of Interventional Radiology, European Institute of Oncology, Milan, Italy

    Gianluigi Orgera

  4. Department of Radiology, University Hospital of Heraklion, Medical School of Crete, Heraklion, Greece

    Miltiadis Krokidis & Dimitrios Tsetis

  5. Department of Gastroenterology, University Hospital of Heraklion, Medical School of Crete, Heraklion, Greece

    Ioannis Mouzas & Elias Kouroumalis

  6. Medical School of Crete, Heraklion, Greece

    Adam Hatzidakis

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  1. Miltiadis Krokidis
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  2. Fabrizio Fanelli
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  3. Gianluigi Orgera
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  4. Dimitrios Tsetis
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  6. Mario Bezzi
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Correspondence to Miltiadis Krokidis.

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Krokidis, M., Fanelli, F., Orgera, G. et al. Percutaneous Palliation of Pancreatic Head Cancer: Randomized Comparison of ePTFE/FEP–Covered Versus Uncovered Nitinol Biliary Stents. Cardiovasc Intervent Radiol 34, 352–361 (2011). https://doi.org/10.1007/s00270-010-9880-4

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  • DOI: https://doi.org/10.1007/s00270-010-9880-4

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