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Short- and Long-Term Outcomes of Laparoscopic Organ-Sparing Resection for Pancreatic Neuroendocrine Neoplasms

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Abstract

Background

Pancreatic neuroendocrine neoplasms (PNENs) are rare neoplasms associated with a long life expectancy after resection. In this setting, patients may benefit from laparoscopic organ-sparing resection. Studies of laparoscopic organ-sparing resection for PNENs are limited. The aim of this study was to evaluate the short- and long-term outcomes of laparoscopic organ-sparing resection for PNENs.

Methods

A retrospective study was performed for patients with PNENs who underwent laparoscopic organ-sparing pancreatectomy between March 2005 and May 2018. The patients’ demographic data, operative results, pathological reports, hospital courses and morbidity, mortality, and follow-up data (until August 2018) were analysed.

Results

Thirty-five patients were included in the final analysis. There were 9 male and 26 female patients, with a median age of 46 years (range 25–75 years). The mean BMI was 24.6 ± 3.3 kg/m2. Nine patients received laparoscopic enucleation (LE), 20 received laparoscopic spleen-preserving distal pancreatectomy (LSPDP), and 6 received laparoscopic central pancreatectomy. The operative time, intraoperative blood loss, transfusion rate, and postoperative hospital stay were 186.4 ± 60.2 min, 165 ± 73.0 ml, 0 days, and 9 days (range 5–23 days), respectively. The morbidity rate, grade ≥ III complication rate, and grade ≥ B pancreatic fistula rate were 34.2%, 11.4%, and 8.7%, respectively, with no mortality. The rate of follow-up was 94.3%, and the median follow-up time was 55 months (range 3–158 months). One patient developed recurrence 36 months after LE and was managed with surgical resection. The other patients survived without metastases or recurrence during the follow-up. One patient had diabetes after LSPDP, and no patients had symptoms of pancreatic exocrine insufficiency. Nineteen patients who underwent LSPDP (16 with the Kimura technique and 3 with the Warshaw technique) were followed. Normal patency of the splenic artery and vein was observed in 14 and 14 patients within 1 month of surgery and in 15 and 14 patients 6 months or more after the operation, respectively. Partial splenic infarction was observed in 3 patients within 1 month of surgery and in no patients 6 months or more after the operation. Three patients eventually developed collateral venous vessels around the gastric fundus and reserved spleen, with one case of variceal bleeding.

Conclusions

Laparoscopic organ-sparing resection for selected cases of PNENs is safe and feasible and has favourable short- and long-term outcomes.

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Funding

There were no funding contributions to this study.

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Authors and Affiliations

  1. Department of Gastrointestinal & Pancreatic Surgery, Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, 158 Shangtang Road, Hangzhou, 310014, Zhejiang Province, China

    Ren-Chao Zhang, Jun Ma, Yi-Ping Mou, Yu-Cheng Zhou, Wei-Wei Jin & Chao Lu

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  1. Ren-Chao Zhang
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  2. Jun Ma
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Correspondence to Yi-Ping Mou.

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Conflict of interest

Ren-Chao Zhang, Jun Ma, Yi-Ping Mou, Yu-Cheng Zhou, Wei-Wei Jin, and Chao Lu have no conflict of interest or financial ties to disclose.

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Informed consent was obtained from all individual participants included in the study. The Institutional Review Board of each institute approved this study.

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Ren-Chao Zhang and Jun Ma have contributed equally to this work.

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Zhang, RC., Ma, J., Mou, YP. et al. Short- and Long-Term Outcomes of Laparoscopic Organ-Sparing Resection for Pancreatic Neuroendocrine Neoplasms. World J Surg 44, 3795–3800 (2020). https://doi.org/10.1007/s00268-020-05707-8

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  • DOI: https://doi.org/10.1007/s00268-020-05707-8

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