Abstract
Backround
The purpose of the study was to assess the role of artificial neural networks (ANNs) in the diagnosis of appendicitis in patients presenting with acute right iliac fossa (RIF) pain and comparing its performance with the assessment made by experienced clinicians and the Alvarado score.
Methods
After training and testing an ANN, data from 60 patients presenting with suspected appendicitis over a 6-month period to a teaching hospital was collected prospectively. Accuracy of diagnosing appendicitis by the clinician, the Alvarado score, and the ANN was compared.
Results
The sensitivity, specificity, and positive and negative predictive values of the ANN were 100%, 97.2%, 96.0%, and 100% respectively. The ability of the ANN to exclude accurately the diagnosis of appendicitis in patients without true appendicitis was statistically significant compared to the clinical performance (p = 0.031) and Alvarado score of ≥6 (p = 0.004) and nearly significant compared to the Alvarado score of ≥7 (p = 0.063).
Conclusions
ANNs can be an effective tool for accurately diagnosing appendicitis and may reduce unnecessary appendectomies.
Similar content being viewed by others
References
Colson M, Skinner KA, Dunnington G (1997) High negative appendectomy rates are no longer acceptable. Am J Surg 174:723–726
Andersson RE, Hugander AP, Ghazi SH, et al (1999) Diagnostic value of disease history, clinical presentation, and inflammatory parameters of appendicitis. World J Surg 23:133–140
Jahn H, Mathiesen FK, Neckelmann K, et al (1997) Comparison of clinical judgment and diagnostic ultrasonography in the diagnosis of acute appendicitis: experience with a score-aided diagnosis. Eur J Surg 163: 433–443
Hale DA, Molloy M, Pearl RH, et al (1997) Appendectomy: a contemporary appraisal. Ann Surg 225:252–261
Leape LL, Ramenofsky ML (1980) Laparoscopy for questionable appendicitis: can it reduce the negative appendectomy rate? Ann Surg 191:410–143
Deutsch AA, Zelikovsky A, Reiss R (1982) Laparoscopy in the prevention of unnecessary appendicectomies: a prospective study. Br J Surg 69:336–337
Alvarado A (1986) A practical score for the early diagnosis of acute appendicitis. Ann Emerg Med 15:557–564
Fenyö G, Lindberg G, Blind P, et al (1997) Diagnostic decision support in suspected acute appendicitis: validation of a simplified scoring system. Eur J Surg 163:831–838
de Dombal FT, Leaper DJ, Staniland JR, et al (1972) Computer-aided diagnosis of acute abdominal pain. Br J Surg 2:9–13
Birnbaum BA, Jeffrey RB Jr (1998) CT and sonographic evaluation of acute right lower quadrant abdominal pain. AJR Am J Roentgenol 170:361–371
Jeffrey RB Jr, Laing FC, Townsend RR (1988) Acute appendicitis: sonographic criteria based on 250 cases. Radiology 167:327–329
Rioux M (1992) Sonographic detection of the normal and abnormal appendix. AJR Am J Roentgenol 158:773–778
Rao PM, Rhea JT, Novelline RA, et al (1998) Effect of computed tomography of the appendix on treatment of patients and use of hospital resources. N Engl J Med 338:141–146
Baxt WG (1991) Use of an artificial neural network for the diagnosis of myocardial infarction. Ann Intern Med 115:843–848
Patil S, Henry JW, Rubenfire M, et al (1993) Neural network in the clinical diagnosis of acute pulmonary embolism. Chest 104:1685–1689
Burke HB (1994) Artificial neural networks for cancer research: outcome prediction. Semin Surg Oncol 10:73–79
Doyle HR, Dvorchik I, Mitchell S, et al (1994) Predicting outcomes after liver transplantation: a connectionist approach. Ann Surg 2:504–508
Hinton GE (1992) How neural networks learn from experience. Sci Am 267:144–151
Eberhart RC, Dobbins RW, Hutton LV (1991) Neural network paradigm comparisons for appendicitis diagnoses. In: Proceedings of 4th Annual IEEE Symposium on Computer-Based Systems, pp 298–304
Dixon JM, Elton RA, Rainey JB, et al (1991) Rectal examination in patients with pain in the right lower quadrant of the abdomen. BMJ 302:386–388
Andersson RE, Hugander AP, Ghazi SH, et al (1999) Diagnostic value of disease history, clinical presentation, and inflammatory parameters of appendicitis. World J Surg 23:133–140
Kalan M, Talbot D (1994) Evaluation of modified Alvarado score in the diagnoses of acute appendicitis. Ann R Coll Surg Engl 76:418–19
Owen TD, Williams H, Stiff G, et al (1992) Evaluation of Alvarado score in acute appendicitis. J R Soc Med 85:87–88
John H, Neff U, Kelemen M (1993) Appendicitis diagnosis today: clinical and ultrasound deductions. World J Surg 17:243–249
Pesonen E, Ohmann C, Eskelinen M, et al (1998) Diagnosis of acute appendicitis in two databases: evaluation of different neighbourhoods with an LVQ neural network. Methods Inf Med 37:59–63
Sheridan WG, White AT, Havard T, et al (1992) Nonspecific abdominal pain: the resource implications. Ann R Coll Surg Engl 74:181–185
Paterson-Brown S (1993) Emergency laparoscopy surgery. Br J Surg 80:279–283
Denizbasi A, Unleur EE (2003) The role of the emergency medicine resident using the Alvarado score in the diagnosis of acute appendicitis compared with the general surgery resident. Eur J Emerg Med 10:296–301
Chan MY, Teo BS, Ng BL (2001) The Alvarado score and acute appendicitis. Ann Acad Med Singapore 30:510–512
Hale DA, Molloy M, Pearl RH, et al (1997) Appendectomy: a contemporary appraisal. Ann Surg 225:252–261
Jones PF (2001) Suspected acute appendicitis: trends in management over 30 years. Br J Surg 88:1570–1577
McGreevy JM, Finlayson SR, Alvarado R, et al (2002) Laparoscopy may be lowering the threshold to operate on patients with suspected appendicitis. Surg Endosc 16:1046–1049
Gammerman A, Thatcher AR (1991) Bayesian diagnostic probabilities without assuming independence of symptoms. Methods Inf Med 30:15–22
Cross SS, Harrison RF, Kennedy RL (1995) Introduction to neural networks. Lancet 346:1135–138l
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Prabhudesai, S.G., Gould, S., Rekhraj, S. et al. Artificial Neural Networks: Useful Aid in Diagnosing Acute Appendicitis. World J Surg 32, 305–309 (2008). https://doi.org/10.1007/s00268-007-9298-6
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00268-007-9298-6