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Usefulness of real-time contrast-enhanced ultrasound guided coaxial needle biopsy for focal liver lesions

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Abstract

Purpose

To evaluate the utility of real-time contrast-enhanced ultrasound (CEUS)-guided coaxial needle biopsies for focal liver lesions (FLL) that were inconspicuous or could not be accurately identified the active site on B-mode ultrasound (US).

Materials and methods

This prospective study included 76 patients who had CEUS-guided coaxial needle biopsies for FLL between December 2015 and June 2017. We recorded characteristics of target lesions. We evaluated conspicuity of target lesions and accuracy of identifying the active site of target lesions on B-mode US and CEUS using a 5-point scale. Patients were divided into three groups, and analyzed according to body mass index (BMI). Based on the final diagnosis, the diagnostic performance was evaluated.

Results

The mean size and depth of target lesions were 41.5 ± 28.5 and 47.9 ± 18.9 mm on CEUS, respectively. In arterial phase, the enhanced pattern of target lesions varied. The conspicuity of target lesions and accuracy of identifying the active site of target lesions was significantly improved on CEUS compared to B-mode US (p < 0.05). The three BMI groups had significant differences in conspicuity of target lesions after using CEUS (p < 0.05). The high BMI group had a greater change in conspicuity of lesions compared to the normal BMI group or the low BMI group (p < 0.05). The sensitivity, specificity, and accuracy of this technique for the diagnosis of FLL were 92.8%, 100%, and 93.4%, respectively.

Conclusion

Real-time CEUS-guided coaxial needle biopsy can be very useful for FLL that are inconspicuous or cannot be accurately identified the active site on B-mode US.

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Acknowledgments

We would like to thank all participants for their support in this study. No grant support needs to be reported.

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Authors and Affiliations

  1. Department of Interventional Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Pan-jia-yuan South Lane, Chaoyang District, Beijing, 100021, China

    Xiaojing Cao, Xiang Zhou & Yujing Xin

  2. Department of Ultrasound, Xingtai City People’s Hospital, Xingtai, China

    Zhenxing Liu

  3. Department of Ultrasound, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Pan-jia-yuan South Lane, Chaoyang District, Beijing, 100021, China

    Xiang Zhou, Chengyun Geng, Qing Chang, Li Zhu, Wenqi Feng & Tianyu Xu

Authors
  1. Xiaojing Cao
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  2. Zhenxing Liu
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  3. Xiang Zhou
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  4. Chengyun Geng
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  5. Qing Chang
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  6. Li Zhu
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  7. Wenqi Feng
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  8. Tianyu Xu
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Corresponding author

Correspondence to Xiang Zhou.

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Funding

This work did not receive funding.

Conflicts of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration, and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants prior to enrollment in the study.

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Cite this article

Cao, X., Liu, Z., Zhou, X. et al. Usefulness of real-time contrast-enhanced ultrasound guided coaxial needle biopsy for focal liver lesions. Abdom Radiol 44, 310–317 (2019). https://doi.org/10.1007/s00261-018-1713-y

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  • DOI: https://doi.org/10.1007/s00261-018-1713-y

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