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Prediction of 5-year survival in advanced-stage ovarian cancer patients based on computed tomography peritoneal carcinomatosis index

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Abdominal Radiology Aims and scope Submit manuscript

Abstract

Objective

To evaluate whether the quantification of peritoneal metastases in advanced-stage ovarian cancer patients using the peritoneal carcinomatosis index, detected by CT (CT-PCI), correlates with the serum levels of tumor marker CA-125 and 5-year survival.

Methods

The CT-PCI was determined in 82 patients with stage III or stage IV ovarian cancer using the Sugarbaker classification prior to cytoreductive surgery. Linear regression analysis was used to correlate CT-PCI and CA-125 levels. Correlation of presurgical CT-PCI, optimal surgical cytoreduction, and 5-year survival was established using binary logistic regression analysis. A score for prediction of 5-year survival probability was established using multivariate backwards binary logistic regression.

Results

Presurgical CT-PCI correlates significantly with presurgical CA-125 serum levels (r = 0.487, P < 0.001). Multivariate binary logistic regression suggested significantly improved 5-year survival with lower CT-PCI and lower ECOG performance scores.

Conclusion

CT-PCI allows quantification of peritoneal disease in advanced-stage ovarian cancer patients, similar to CA-125. CT-PCI in combination with ECOG performance has the potential to help evaluate the 5-year survival probability.

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Fig. 1

Adapted from “Duhr et al. [23]”

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Acknowledgments

We thank Jesaja K. Brinkmann for his help with data retrieval and preparation of CT images for publication.

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    Authors and Affiliations

    1. Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA

      Daniel Diaz-Gil, Florian J. Fintelmann, Sanaz Molaei, Azadeh Elmi, Sandeep S. Hedgire & Mukesh G. Harisinghani

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    1. Daniel Diaz-Gil
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    2. Florian J. Fintelmann
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    3. Sanaz Molaei
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    4. Azadeh Elmi
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    5. Sandeep S. Hedgire
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    6. Mukesh G. Harisinghani
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    Correspondence to Daniel Diaz-Gil.

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    The authors declare that they have no conflict of interest.

    Ethical approval

    All procedures performed in studies involving human participants were in accordance with the ethical standards of the Partners Institutional Review Board (protocol number: 2012P001096) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

    Additional information

    The authors Daniel Diaz-Gil and Florian J. Fintelmann contributed equally to this work.

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    Diaz-Gil, D., Fintelmann, F.J., Molaei, S. et al. Prediction of 5-year survival in advanced-stage ovarian cancer patients based on computed tomography peritoneal carcinomatosis index. Abdom Radiol 41, 2196–2202 (2016). https://doi.org/10.1007/s00261-016-0817-5

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    • DOI: https://doi.org/10.1007/s00261-016-0817-5

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