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The usefulness of [68 Ga]Ga-DOTA-JR11 PET/CT in patients with meningioma: comparison with MRI

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

Clinical studies of PET imaging using SSTR2 agonists have demonstrated high accuracy and correlation with SSTR2 expression in meningiomas. However, the usefulness of the SSTR2 antagonist with [68 Ga]Ga-DOTA-JR11 is uncertain. To evaluate the diagnostic performance of [68 Ga]Ga-DOTA-JR11 PET/CT and to clarify tumor characteristics in patients with suspected meningiomas.

Materials and methods

Patients with suspected de novo or recurrent meningioma in complex locations or atypical images were enrolled from August 2021 to October 2022 in prospective study. All patients underwent contrast-enhanced MRI (CE-MRI), [68 Ga]Ga-DOTA-JR11 PET/CT, and histopathological evaluation. Tumor uptake of [68 Ga]Ga-DOTA-JR11 was measured by SUVmax and tumor-endocranium ratio (TBR). Diagnostic performance was compared between PET and MRI.

Results

Of 36 (50.0 ± 13.0 years of age, 20 women) patients, 32 were histopathologically confirmed meningiomas and four with other tumors. [68 Ga]Ga-DOTA-JR11 uptake was significantly higher in meningioma patients than in those with other tumors (SUVmax: 13.6 ± 7.7 vs. 5.2 ± 3.0, P < 0.001; TBR: 64.2 ± 27.7 vs. 25.0 ± 18.9, P = 0.001). [68 Ga]Ga-DOTA-JR11 PET/CT detected 31 meningiomas, while CE-MRI detected 17 meningiomas of 25 initial diagnosis and 11 recurrent tumors; [68 Ga]Ga-DOTA-JR11 PET had an incremental diagnostic value of 24% (6/25) over MRI in the group of initial diagnosis. There was no statistically significant difference in diagnostic efficacy between PET and MRI (P = 0.45) for all 36 patients. In skull base meningiomas, PET provided a more definitive diagnosis of pituitary involvement (in 12, not in12), compared to MRI (in eight, possible in six, possible not in six, not in four). PET revealed bone involvement in all 14 patients proven by pathology, while MRI identified only 11.

Conclusions

[68 Ga]Ga-DOTA-JR11 PET/CT provided high image quality and presented an ideal diagnostic performance in detecting meningioma and evaluating the involvement of the pituitary and bone. The study provides valuable evidence for the use of [68 Ga]Ga-DOTA-JR11 PET/CT as a complementary imaging modality to CE-MRI in the evaluation of meningiomas.

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding authors on reasonable request.

References

  1. Ostrom QT, Cioffi G, Gittleman H, et al. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2012–2016. Neuro Oncol. 2019;21(Suppl 5):v1–100.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Nagai Yamaki V, de Souza Godoy LF, Alencar Bandeira G, et al. Dural-based lesions: is it a meningioma? Neuroradiology. 2021;63(8):1215–25.

    Article  PubMed  Google Scholar 

  3. Prasad RN, Perlow HK, Bovi J, et al. (68)Ga-DOTATATE PET: the future of meningioma treatment. Int J Radiat Oncol Biol Phys. 2022;113(4):868–71.

    Article  PubMed  Google Scholar 

  4. Silva CB, Ongaratti BR, Trott G, et al. Expression of somatostatin receptors (SSTR1-SSTR5) in meningiomas and its clinicopathological significance. Int J Clin Exp Pathol. 2015;8(10):13185–92.

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Hofman MS, Lau WF, Hicks RJ. Somatostatin receptor imaging with 68Ga DOTATATE PET/CT: clinical utility, normal patterns, pearls, and pitfalls in interpretation. Radiographics. 2015;35(2):500–16.

    Article  PubMed  Google Scholar 

  6. Purandare NC, Puranik A, Shah S, et al. Differentiating dural metastases from meningioma: role of 68Ga DOTA-NOC PET/CT. Nucl Med Commun. 2020;41(4):356–62.

    Article  CAS  PubMed  Google Scholar 

  7. Afshar-Oromieh A, Giesel FL, Linhart HG, et al. Detection of cranial meningiomas: comparison of 68Ga-DOTATOC PET/CT and contrast-enhanced MRI. Eur J Nucl Med Mol Imaging. 2012;39(9):1409–15.

    Article  PubMed  Google Scholar 

  8. Rachinger W, Stoecklein VM, Terpolilli NA, et al. Increased 68Ga-DOTATATE uptake in PET imaging discriminates meningioma and tumor-free tissue. J Nucl Med. 2015;56(3):347–53.

    Article  CAS  PubMed  Google Scholar 

  9. Ivanidze J, Roytman M, Lin E, et al. Gallium-68 DOTATATE PET in the evaluation of intracranial meningiomas. J Neuroimaging. 2019;29(5):650–6.

    Article  PubMed  Google Scholar 

  10. Galldiks N, Albert NL, Sommerauer M, et al. PET imaging in patients with meningioma-report of the RANO/PET Group. Neuro Oncol. 2017;19(12):1576–87.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Goldbrunner R, Stavrinou P, Jenkinson MD, et al. EANO guideline on the diagnosis and management of meningiomas. Neuro Oncol. 2021;23(11):1821–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Fani M, Braun F, Waser B, et al. Unexpected sensitivity of sst2 antagonists to N-terminal radiometal modifications. J Nucl Med. 2012;53(9):1481–9.

    Article  CAS  PubMed  Google Scholar 

  13. Cescato R, Erchegyi J, Waser B, et al. Design and in vitro characterization of highly sst2-selective somatostatin antagonists suitable for radiotargeting. J Med Chem. 2008;51(13):4030–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Zhu W, Cheng Y, Wang X, et al. Head-to-head comparison of (68)Ga-DOTA-JR11 and (68)Ga-DOTATATE PET/CT in patients with metastatic, well-differentiated neuroendocrine tumors: a prospective study. J Nucl Med. 2020;61(6):897–903.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Nicolas GP, Schreiter N, Kaul F, et al. Sensitivity comparison of (68)Ga-OPS202 and (68)Ga-DOTATOC PET/CT in patients with gastroenteropancreatic neuroendocrine tumors: a prospective phase II imaging study. J Nucl Med. 2018;59(6):915–21.

    Article  CAS  PubMed  Google Scholar 

  16. Albrecht J, Exner S, Grötzinger C, et al. Multimodal imaging of 2-cycle PRRT with (177)Lu-DOTA-JR11 and (177)Lu-DOTATOC in an orthotopic neuroendocrine xenograft tumor mouse model. J Nucl Med. 2021;62(3):393–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Dalm SU, Nonnekens J, Doeswijk GN, et al. Comparison of the therapeutic response to treatment with a 177Lu-labeled somatostatin receptor agonist and antagonist in preclinical models. J Nucl Med. 2016;57(2):260–5.

    Article  CAS  PubMed  Google Scholar 

  18. Werner-Wasik M, Nelson AD, Choi W, et al. What is the best way to contour lung tumors on PET scans? Multiobserver validation of a gradient-based method using a NSCLC digital PET phantom. Int J Radiat Oncol Biol Phys. 2012;82(3):1164–71.

    Article  PubMed  Google Scholar 

  19. Fedorov A, Beichel R, Kalpathy-Cramer J, et al. 3D Slicer as an image computing platform for the Quantitative Imaging Network. Magn Reson Imaging. 2012;30(9):1323–41.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Afshar-Oromieh A, Wolf MB, Kratochwil C, et al. Comparison of 68Ga-DOTATOC-PET/CT and PET/MRI hybrid systems in patients with cranial meningioma: Initial results. Neuro Oncol. 2015;17(2):312–9.

    Article  CAS  PubMed  Google Scholar 

  21. Bikmaz K, Mrak R, Al-Mefty O. Management of bone-invasive, hyperostotic sphenoid wing meningiomas. J Neurosurg. 2007;107(5):905–12.

    Article  PubMed  Google Scholar 

  22. Zwirner K, Paulsen F, Schittenhelm J, et al. Integrative assessment of brain and bone invasion in meningioma patients. Radiat Oncol. 2019;14(1):132.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Kunz WG, Jungblut LM, Kazmierczak PM, et al. Improved detection of transosseous meningiomas using (68)Ga-DOTATATE PET/CT compared with contrast-enhanced MRI. J Nucl Med. 2017;58(10):1580–7.

    Article  CAS  PubMed  Google Scholar 

  24. Ghosal N, Dadlani R, Gupta K, et al. A clinicopathological study of diagnostically challenging meningioma mimics. J Neurooncol. 2012;106(2):339–52.

    Article  PubMed  Google Scholar 

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Acknowledgements

We are grateful to Xiaoguang Qiu for the valuable suggestion and input during the course of this clinical research.

Funding

This work was supported by the National High Level Hospital Clinical Research Funding (grant number: 2022-PUMCH-B-070) and National Natural Science Foundation of China (grant numbers: 82001778).

Author information

Author notes

  1. Peipei Wang, Shuai Liu, and Xiaojie Li contributed equally to this work.

Authors and Affiliations

  1. Department of Nuclear Medicine, Beijing , Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China

    Peipei Wang & Xin Cheng

  2. Department of Radiation Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

    Shuai Liu

  3. Beijing Neurosurgical Institute, Capital Medical University, Beijing, China

    Shuai Liu, Xing Liu & Shaowu Li

  4. Department of Neurosurgery, Fengtai District, Beijing Tiantan Hospital, Capital Medical University, No. 119, the West Southern 4Th Ring Road, Beijing, 100073, China

    Xiaojie Li & Zhen Wu

  5. Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

    Shaowu Li

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  1. Peipei Wang
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Contributions

Guarantors of integrity of entire study, all authors; study concepts/study design or data acquisition or data analysis/interpretation, all authors; manuscript drafting or manuscript revision for important intellectual content, all authors; approval of final version of submitted manuscript, all authors; agrees to ensure any questions related to the work are appropriately resolved, all authors; literature research, P.W., S.L., X.L., X.C.; clinical studies, P.W., S.L., X.L., X.L., S.L., Z.W., X.C.; experimental studies, P.W., Z.L., M.J., Y.S.; statistical analysis, P.W., S.L., X.L., Z.W., X.C.; and manuscript editing, P.W., S.L., X.L., X.L., S.L., Z.W., X.C.

Corresponding authors

Correspondence to Zhen Wu or Xin Cheng.

Ethics declarations

Ethics approval

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Peking Union Medical College Hospital (Date: 27-Apr-2020/No: ZS-1675).

Consent to participate

Written informed consent was obtained from every patient.

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The authors affirm that human research patients provided informed consent for publication of the images in Figs. 2, 3, and 4.

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The authors declare no competing interests.

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Wang, P., Liu, S., Li, X. et al. The usefulness of [68 Ga]Ga-DOTA-JR11 PET/CT in patients with meningioma: comparison with MRI. Eur J Nucl Med Mol Imaging 51, 218–225 (2023). https://doi.org/10.1007/s00259-023-06391-1

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