Abstract.
We have developed a procedure for the prediction of hydrodynamic coefficients and other solution properties of macromolecules and macromolecular complexes whose volumes have been generated from electron microscopy images. Starting from the structural files generated in the three-dimensional reconstructions of such molecules, it is possible to construct a hydrodynamic model for which the solution properties can be calculated. We have written a computer program, HYDROMIC, that implements all the stages of the calculation. The use of this procedure is illustrated with a calculation of the solution properties of the volume of the cytosolic chaperonin CCT, obtained from cryoelectron microscopy images.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Revised version: 14 June 2001
Electronic Publication
Rights and permissions
About this article
Cite this article
García de la Torre, .J., Llorca, .O., Carrascosa, .J. et al. HYDROMIC: prediction of hydrodynamic properties of rigid macromolecular structures obtained from electron microscopy images. Eur Biophys J 30, 457–462 (2001). https://doi.org/10.1007/s002490100176
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s002490100176