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Subsurface thermal sensitivity evaluation of magnetic nanoparticles for theranostics using infrared thermography

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Abstract

Superparamagnetic ferrites are potential materials explored for magnetic nanoparticle hyperthermia. Theranostics utilizing infrared thermography with iron oxide nanoparticles demand better heating characteristics and thermal sensitivity that are affected by the biological fluid and absorption by the tissue layer. Agar gel phantoms were incorporated with the ferrite particles dispersed in albumin and water, where the analyses present improved sensitivity with Mn-doped Fe3O4 compared to magnetite. Mn-doping shows attenuation in temperature difference from 6.7K to about 2K with layer thickness up to 2mm. The Lambert absorption coefficient determined for the phantom layers from the subsurface sensing is 0.07cm− 1 with the Mn-doped particles both in water and albumin. A prudent investigation of the absorbance characteristics of phantom layers suggests hyperthermia with long-wave infrared thermography (8–13μm) as a promising combination for the theranostics of subcutaneous tumours.

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Acknowledgements

The authors acknowledge the Department of Science and Technology, Government of India for the experimental facilities and the Science and Engineering Research Board (SERB) project (CRG/2018/000939).

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  1. Magnetic Materials Laboratory, Department of Physics, National Institute of Technology, 620015, Tiruchirappalli, India

    J. Shebha Anandhi & R. Justin Joseyphus

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  1. J. Shebha Anandhi
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  2. R. Justin Joseyphus
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J. Shebha Anandhi: Data curation, Formal analysis; Investigation, Methodology, Resources, Software, Validation, Visualization, Roles/Writing - original draft, Writing - review & editing. R. Justin Joseyphus: Conceptualization, Supervision, Writing - review & editing.

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Correspondence to R. Justin Joseyphus.

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Anandhi, J.S., Joseyphus, R.J. Subsurface thermal sensitivity evaluation of magnetic nanoparticles for theranostics using infrared thermography. Heat Mass Transfer 59, 803–816 (2023). https://doi.org/10.1007/s00231-022-03293-0

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