Abstract.
In 45 women with Colles' fracture, two types of complementary medical treatment (calcitonin with calcium [SCT+Ca] and calcium alone [Ca]) were compared with placebo. Consecutive patients were assigned randomly to one of the three study groups at the time of inclusion in the study: 15 women (68.6 ± 5.7 years) were given 100 IU/day I.M. of SCT plus 1200 mg of elemental Ca for 10 successive days each month; 15 women (71.7 ± 6.1 years) were given only 1200 mg of elemental Ca for 10 days each month; and 15 women (66.9 ± 7.9 years) were treated with placebo. Biochemical and radiogrammetric studies were made at baseline and after 1 year of treatment. In the SCT+Ca group tartrate-resistant acid phosphatase decreased (Wilcoxon test, P= 0.014) and the metacarpal index and the cortical and total area (CA/TA) ratio increased (both P= 0.001). In the group treated with Ca alone, no changes were observed. In the placebo group, the metacarpal index and CA/TA decreased (P= 0.015 and P= 0.007, respectively). Ca alone, at the dosage used here, inhibited bone loss after Colles' fracture. The addition of SCT to Ca administration not only impeded bone loss but significantly increased cortical bone mass.
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Received: 9 July 1996 / Accepted: 3 January 1997
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Crespo, R., Revilla, M., Crespo, E. et al. Complementary Medical Treatment for Colles' Fracture: A Comparative, Randomized, Longitudinal Study . Calcif Tissue Int 60, 567–570 (1997). https://doi.org/10.1007/s002239900281
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DOI: https://doi.org/10.1007/s002239900281