Human vestibular perceptual thresholds for pitch tilt are slightly worse than for roll tilt across a range of frequencies

Abstract

Vestibular perceptual thresholds measure vestibular sensory and perceptual noise by quantifying how small of a passive self-motion an individual is able to reliably perceive. Vestibular thresholds have clinical and operational relevance, as they are elevated in vestibular migraine patients, and even healthy individuals with higher (i.e., worse) thresholds have degraded balance. Vestibular thresholds have been quantified across a range of frequencies (motion durations) for rotations and translations, with differences identified for different motion directions (e.g., up/down thresholds are higher than those for left/right motions). While roll tilt thresholds have been well quantified, pitch tilt thresholds have not. Here we aim to quantify pitch tilt thresholds across a range of frequencies and test whether they are higher than in those for roll tilt. In ten normal subjects, we found pitch tilt thresholds at 0.15, 0.2, 0.5, and 1 Hz averaged 1.66, 1.61, 0.99, 0.51 degrees, respectively. Using a general linear model, we found subjects’ pitch tilt thresholds were slightly, but significantly, higher than their roll tilt thresholds across all frequencies tested. These differences were approximately 10% at 0.15, 0.2, and 1 Hz and 3% at 0.5 Hz. Pitch tilt thresholds exhibited a similar frequency response as in roll tilt (decreasing a higher frequencies). They also had substantial inter-individual variability, which correlated across pitch tilt frequencies and between pitch and roll tilt thresholds. We discuss why pitch tilt thresholds might be higher, including the pitched-up orientation of the utricular plane of the otoliths, compared to previous studies, and discuss functional implications.