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Peptide-derived coordination frameworks for biomimetic and selective separation

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Abstract

Peptide-derived metal–organic frameworks (PMOFs) have emerged as a class of biomimetic materials with attractive performances in analytical and bioanalytical chemistry. The incorporation of biomolecule peptides gives the frameworks conformational flexibility, guest adaptability, built-in chirality, and molecular recognition ability, which greatly accelerate the applications of PMOFs in enantiomeric separation, affinity separation, and the enrichment of bioactive species from complicated samples. This review focuses on the recent advances in the engineering and applications of PMOFs in selective separation. The unique biomimetic size-, enantio-, and affinity-selective performances for separation are discussed along with the chemical structures and functions of MOFs and peptides. Updates of the applications of PMOFs in adaptive separation of small molecules, chiral separation of drug molecules, and affinity isolation of bioactive species are summarized. Finally, the promising future and remaining challenges of PMOFs for selective separation of complex biosamples are discussed.

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Scheme 1
Fig. 1

Reproduced with permission from ref. [42], © Wiley–VCH 2021. c The coordination of the γ-glutathione analogue and Hg(II) to further assemble into left-handed fibers. Reproduced with permission from ref. [43], © ACS publisher 2018

Fig. 2

Reproduced with permission from ref. [55], © ACS publisher 2017. b Grafting peptides into MOF cavities via in situ solid-phase peptide synthesis. Reproduced with permission from ref. [58], © ACS publisher 2015

Fig. 3

Reproduced with permission from ref. [66], © ACS publisher 2012. b The crystalline frameworks formed by Zn(II) and carnosine (Car) exhibiting selective CO2 adsorption through dispersion interactions. Green, Zn; blue, N; gray, C; red, O; white, H. (c) The structure of human hemoglobin. (d, e) Zn(GGH) with flexible pore conformation in DMSO (d) and DMF (e) for adaptive adsorption of guest molecules. Green, Zn; blue, N; red, O; gray, C

Fig. 4

Reproduced with permission from ref. [67], © Wiley–VCH 2015. b Mirror symmetry of the L-crystal and D-crystal frameworks synthesized from Ag(I) and L-, D-type peptides. Reproduced with permission from ref. [68], © Wiley–VCH 2014. c Binding geometries of (+ , −)-ephedrine (EP) enantiomers in Cu(GHG) (GHG, Gly-His-Gly). Hydrogen bonds are represented as dotted lines. Dark blue, Cu; blue, N; gray, C; red, O; white, H. d Solid-phase extraction separation of EP by using Cu(GHG) as chiral stational phase. The EP racemate before and after passing through the MOF bed was characterizez with high-performance liquid chromatography. Reproduced with permission from ref. [69], © ACS publisher 2017

Fig. 5

Reproduced with permission from ref. [54], © Royal Society of Chemistry 2018. b The percentage of Aβ photooxidation under different conditions identified by matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry. Reproduced with permission from ref. [73], © Wiley–VCH 2019

Fig. 6

Reproduced with permission from ref. [74], © Elsevier 2020. c Affinity peptide–modified Cu-TCPP for the enrichment and detection of programmed death-ligand 1 (PD-L1) exosomes. d The SPR signal response for exosomes and other interference species with peptide-modified Cu-TCPP as substrates. Reproduced with permission from ref. [76], © Elsevier 2020

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Acknowledgements

Financial support from the National Natural Science Foundation of China (22122411, 21874141, 21974143, and 22174145) and the Chinese Academy of Sciences (E01Z0112) is gratefully acknowledged.

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  1. Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China

    Yongming Li, Han Gao, Yulong Jin, Rui Zhao & Yanyan Huang

  2. University of Chinese Academy of Sciences, Beijing, 100049, China

    Yongming Li, Han Gao, Yulong Jin, Rui Zhao & Yanyan Huang

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Published in the topical collection Young Investigators in (Bio-)Analytical Chemistry 2023 with guest editors Zhi-Yuan Gu, Beatriz Jurado-Sánchez, Thomas H. Linz, Leandro Wang Hantao, Nongnoot Wongkaew, and Peng Wu.

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Li, Y., Gao, H., Jin, Y. et al. Peptide-derived coordination frameworks for biomimetic and selective separation. Anal Bioanal Chem 415, 4079–4092 (2023). https://doi.org/10.1007/s00216-023-04761-0

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