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The synthesis and functionalization of metal organic frameworks and their applications for the selective separation of proteins/peptides

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Abstract

Recently, proteins separation has drawn great interest for the full investigation of a proteome because the proteins separation is the precondition when conducting clinical research or proteomics research. Metal organic frameworks (MOFs) are fabricated via covalent connection between organic ligands and metal ions/clusters units. MOFs have attracted much attention due to the ultra-high specific surface area, tunable structure, more metal site or unsaturated site, and chemical stability. Over the past decade, different functionalization types of MOFs have been reported in combination with amino acids, nucleic acids, proteins, polymers, and nanoparticles for various applications. In this review, the synthesis and functionalization of MOFs have been thoroughly discussed, and we introduced the existing problems and development trends in these fields. Furthermore, MOFs as advanced adsorbents for selective separation of proteins/peptides are summarized. Additionally, we present a comprehensive prospects and challenges in the preparation of robust functional MOFs-based adsorbents and make a final outlook on their future development prospects in selective separation of proteins/peptides.

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Abbreviations

4,4′-bpy:

4,4′-Bipyridine

TMA:

Benzene-1,3,5-tricarboxylate

BDC:

Terephthalic acid

BTB:

1,3,5-(4-Carboxylphenyl)-benzene

DABDC:

Diaminobenzenedicarboxylate or 2,5-diaminoterephthalate

BPTC:

Benzophenone-3,3′,4,4′-tetracarboxylate

EQCM:

Electrochemical quartz crystal microbalance

H3BTC:

Ttimesic acid

TCPP:

Tetrakis (4-carboxyphenyl) porphyrin

DMNP:

Dimethyl-4-nitrophenyl phosphate

BPA:

Bisphenol-A

CDs:

Carbon dots

BDCH2 :

1,4-Benzene dicarboxylate acid

DEF:

N, N′-diethylformamide

MeSA:

Methanesulfonic acid

PZDC:

Pyrazine-3,5-dicarboxylic acid

PVA:

Poly (vinyl alcohol)

AFI:

Air-flow impacting

H4HDTA:

2,5-Dihydroxyterephthalic acid

HepG2:

Hepatocellular carcinoma cells

Cyt c:

Cytochrome c

QPM:

Quaternized poly (2,6-dimethyl phenylene oxide)

PU:

Polyurethane

CTA:

Chain-transfer agent

IEM:

2-Isocyanatoethyl methacrylate

TETA:

Triethylenetetramine

PPy:

Polypyrrole

BSA:

Bovine serum albumin

HSA:

Human serum albumin

PDC:

2,5-Pyridinedicarboxylic acid

PA:

Phytic acid

T2DM:

Type 2 diabetes mellitus

Hb:

Hemoglobin

β-CN:

β-Casein

IgG:

Immunoglobulin G

FcgR:

Fcg receptors

FBP:

Fructose-1,6-bisphosphate trisodium

GO:

Graphene oxide

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This work was supported by the National Key Research and Development Program of China (2016YFA0203101), Natural Science Foundation of China (Nos. 21575076 and 21621003), and the Natural Science Foundation of Ningxia Province (2023AAC03892).

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Authors and Affiliations

  1. State Key Laboratory of Rare Metal Special Material, Northwest Rare Metal Material Research Institute Ningxia Co., Ltd., Ningxia, 753000, China

    Jundong Wang, Wen Luo & Jingming Zhong

  2. China Nonferrous Metal Mining (Group) Co., Ltd., Beijing, 100029, China

    Jundong Wang & Jingming Zhong

  3. Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, 100081, China

    Tingxia Hu

  4. MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, China

    Qiang Han & Mingyu Ding

Authors
  1. Jundong Wang
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  2. Tingxia Hu
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  3. Qiang Han
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  4. Wen Luo
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  5. Jingming Zhong
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  6. Mingyu Ding
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Corresponding authors

Correspondence to Tingxia Hu, Jingming Zhong or Mingyu Ding.

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Wang, J., Hu, T., Han, Q. et al. The synthesis and functionalization of metal organic frameworks and their applications for the selective separation of proteins/peptides. Anal Bioanal Chem 415, 5859–5874 (2023). https://doi.org/10.1007/s00216-023-04843-z

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  • DOI: https://doi.org/10.1007/s00216-023-04843-z

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