Effect of a ketogenic meal on cognitive function in elderly adults: potential for cognitive enhancement
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Glucose is the principal energy substrate for the brain, although ketone bodies are an effective alternative. Evidence suggests that elevation of plasma ketone body levels through oral intake of medium chain triglycerides (MCTs) may improve cognitive function.
We tried to examine the possible effects of a ketogenic meal serving on cognition in elderly non-demented subjects.
Subjects were 19 non-demented elderly adults over 60 years old (13 females; mean age: 66.1 ± 2.9 years) who underwent neurocognitive tests 90 and 180 min after oral intake of a ketogenic meal (Ketonformula®) containing 20 g of MCTs and an isocaloric placebo meal without MCTs on separate days.
Elevation of plasma ketone concentration after intake of a single ketogenic meal containing 20 g of MCTs was confirmed (all p < 0.001). As for cognition, improvements were observed in the digit span test, Trail-Making Test B, and the global score (Z = −2.4, p = 0.017) following the ketogenic meal and the change in the executive functioning score was positively correlated with that of the plasma β-hydroxybutyrate level. The cognition-enhancing effect was observed predominantly for individuals who had a relatively low global score at baseline (Z = −2.8, p = 0.005), compared to individuals with a high global score (Z = −0.7, p = 0.51).
Plasma levels of ketone bodies were successfully increased after intake of the ketogenic meal. The ketogenic meal was suggested to have positive effects on working memory, visual attention, and task switching in non-demented elderly.
Keywordsβ-hydroxybutyrate Cognition Elderly Ketogenic meal Medium chain triglycerides
This study was funded by a research grant from Ryoshoku, the Food Science Institute Foundation, Japan.
K.A., T.T., and H.T. are employees of Meiji Co., Ltd., and Meiji817-B, the ketogenic meal used in the study, was provided by the company.
Compliance with ethical standards
This study was performed in accordance with the Declaration of Helsinki and approved by the ethics committee of the National Center of Neurology and Psychiatry, Japan.
- Hasselbalch SG, Madsen PL, Hageman LP, Olsen KS, Justesen N, Holm S, Paulson OB (1996) Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia. Am J Phys 270:E746–E751Google Scholar
- Henderson ST, Poirier J (2011) Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study. BMC Med Genet 12:137CrossRefPubMedPubMedCentralGoogle Scholar
- Kashiwaya Y, Bergman C, Lee JH, Wan R, King MT, Mughal MR, Okun E, Clarke K, Mattson MP, Veech RL (2013) A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease. Neurobiol Aging 34:1530–1539CrossRefPubMedGoogle Scholar
- Krikorian R, Shidler MD, Dangelo K, Couch SC, Benoit SC, Clegg DJ (2012) Dietary ketosis enhances memory in mild cognitive impairment. Neurobiol Aging 425:e19–e27Google Scholar
- Lezak MD, Howieson DB, Loring DW (2004) Neuropsychological assessment. Oxford University Press, NYGoogle Scholar
- Page KA, Williamson A, Yu N, McNay EC, Dzuira J, McCrimmon RJ, Sherwin RS (2009) Medium-chain fatty acids improve cognitive function in intensively treated type 1 diabetic patients and support in vitro synaptic transmission during acute hypoglycemia. Diabetes 58:1237–1244CrossRefPubMedPubMedCentralGoogle Scholar
- Thevenet J, De Marchi U, Domingo, JS, Christinat N, Bultot L, Lefebvre G, Sakamoto K, Descombes P, Masoodi M, Wiederkehr A (2016) Medium-chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte-neuron lactate and ketone body shuttle systems. FASEB J 30:1913–1926Google Scholar
- Tominaga D (2005) The standardization of the Ryudai’s trail making test (RTMT): from attentional function and working memory’s viewpoint. University of the Ryukyus Repository 67:243–252Google Scholar
- Wechsler D (1987) Wechsler memory scale-revised. Psychological Corporation, San AntonioGoogle Scholar
- Wechsler D (1997) Wechsler Adult Intelligence Scale (3rd edn.). Psychological Corporation, San AntonioGoogle Scholar