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Protective effects of curcumin on chemical and drug-induced cardiotoxicity: a review

  • Review Article
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Abstract

Cardiotoxicity is a major adverse effect that can be induced by both therapeutic agents and industrial chemicals. The pathogenesis of such cardiac damage is multifactorial, often injuring the cardiac tissue by generating free radicals, oxidative stress, and/or inflammation. Curcumin (CUR) is a bright yellow chemical produced by Curcuma longa plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. Administration of CUR has been reported to ameliorate the chemical and drug-induced cardiac injury in several studies. CUR has been suggested to act as an effective candidate against oxidative stress and inflammation in heart tissue via regulation of Nrf2 and suppression of p38 MAPK/NF-κB and NLRP3 inflammasomes. The anti-apoptotic properties of CUR have also been reported to modulate the AMPK, Akt, JNK, and ERK signaling pathways. This review explores the potential protective effects of CUR regarding the detrimental effects often observed in cardiac tissue following exposure to several chemicals including drugs.

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Abbreviations

ALP:

Alkaline phosphate

ALT:

Alanine aminotransferase

AMPK:

AMP-activated protein kinase

ASC:

Apoptosis-associated speck-like protein

AST:

Aspartate aminotransferase

BEV:

Bevacizumab

CAT:

Catalase

CBR1:

Carbonyl reductase type 1

CHF:

Congestive heart failure

CK:

Creatine kinase

COX-2:

Cyclooxygenase-2

CP:

Cisplatin

CPP:

Cyclophosphamide

CPT-11:

Irinotecan

CUR:

Curcumin

cTnI:

Cardiac troponin I

DNR:

Daunorubicin

DOX:

Doxorubicin

ECG:

Electrocardiographic

GPx:

Glutathione peroxidase

GSH:

Reduced glutathione

HO-1:

Heme oxygenase-1

IκB:

I kappa-B

IKK:

IκB kinase

IL:

Interleukin

iNOS:

Inducible nitric oxide synthase

ISO:

Isoproterenol

JNK:

c-Jun N-terminal protein kinases

Keap1:

Kelch-like ECH-associated protein 1

LDH:

Lactate dehydrogenase

MDA:

Malondialdehyde

MET:

Metformin

MMP:

Mitochondrial membrane potential

mPTP:

Permeability transition pore

NF-κB:

Nuclear factor-kappa B

NLRP3:

NOD-like receptor family pyrin domain containing 3

Nrf2:

Nuclear factor E2-related factor 2

NQO-1:

NAD (P) H: quinone oxidoreductase

p38 MAPK:

p38 mitogen-activated protein kinase

PIO:

Pioglitazone

ROS:

Reactive oxygen species

SDH:

Succinate dehydrogenase

SOD:

Superoxide dismutase

TBARS:

Thiobarbituric acid-reactive species

TNF-α:

Tumor necrosis factor-α

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Acknowledgements

The authors are thankful to Mashhad University of Medical Sciences for financial support.

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Authors and Affiliations

  1. Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran

    Fatemeh Yarmohammadi

  2. Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Fatemeh Yarmohammadi & Gholamreza Karimi

  3. Center for Environmental Occupational Risk Analysis and Management, College of Public Health, University of South Florida, Tampa, FL, 33617, USA

    A. Wallace Hayes

  4. Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Gholamreza Karimi

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  1. Fatemeh Yarmohammadi
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  2. A. Wallace Hayes
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  3. Gholamreza Karimi
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GhK conceived and designed research; GhK and RR revised and edited the manuscript; FY wrote the manuscript; All authors read and approved the final version of the manuscript. The authors declare that all data were generated in-house and that no paper mill was used.

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Correspondence to Gholamreza Karimi.

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Yarmohammadi, F., Hayes, A.W. & Karimi, G. Protective effects of curcumin on chemical and drug-induced cardiotoxicity: a review. Naunyn-Schmiedeberg's Arch Pharmacol 394, 1341–1353 (2021). https://doi.org/10.1007/s00210-021-02072-8

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