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Piperine and Its Role in Chronic Diseases

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Anti-inflammatory Nutraceuticals and Chronic Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 928))

Abstract

Alkaloids include a family of naturally occurring chemical compounds containing mostly basic nitrogen atoms. Piperine is an alkaloid present in black pepper (Piper nigrum), one of the most widely used spices, in long pepper (Piper longum), and other Piper species fruits belonging to the family of Piperaceae. Piperine is responsible for the black pepper distinct biting quality. Piperine has many pharmacological effects and several health benefits, especially against chronic diseases, such as reduction of insulin-resistance, anti-inflammatory effects, and improvement of hepatic steatosis. The aim of this chapter is to summarize the effects of piperine, alone or in combination with other drugs and phytochemicals, in chronic diseases.

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Author information

Authors and Affiliations

  1. Department of Internal Medicine and Therapeutics, Fondazione IRCCS Policlinico S. Matteo, University of Pavia, P.le C. Golgi 2, 27100, Pavia, Italy

    Giuseppe Derosa & Pamela Maffioli

  2. Center for Prevention, Surveillance, Diagnosis and Treatment of Rare Diseases, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

    Giuseppe Derosa & Pamela Maffioli

  3. Center for the Study of Endocrine-Metabolic Pathophysiology and Clinical Research, University of Pavia, Pavia, Italy

    Giuseppe Derosa

  4. Laboratory of Molecular Medicine, University of Pavia, Pavia, Italy

    Giuseppe Derosa

  5. PhD School in Experimental Medicine, University of Pavia, Pavia, Italy

    Pamela Maffioli

  6. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  7. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, P.O. Box 91779-48564, Mashhad, Iran

    Amirhossein Sahebkar

Authors
  1. Giuseppe Derosa
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  2. Pamela Maffioli
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  3. Amirhossein Sahebkar
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Corresponding authors

Correspondence to Giuseppe Derosa or Amirhossein Sahebkar .

Editor information

Editors and Affiliations

  1. Banaras Hindu University , Varanasi, Uttar Pradesh, India

    Subash Chandra Gupta

  2. MD Anderson Cancer Center, University of Texas, Houston, Texas, USA

    Sahdeo Prasad

  3. Anti-Inflammation Research Institute, San Diego, California, USA

    Bharat B. Aggarwal

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© 2016 Springer International Publishing Switzerland

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Derosa, G., Maffioli, P., Sahebkar, A. (2016). Piperine and Its Role in Chronic Diseases. In: Gupta, S., Prasad, S., Aggarwal, B. (eds) Anti-inflammatory Nutraceuticals and Chronic Diseases. Advances in Experimental Medicine and Biology, vol 928. Springer, Cham. https://doi.org/10.1007/978-3-319-41334-1_8

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